LEADER 03405nam 2200661 a 450 001 9910459551403321 005 20200520144314.0 010 $a1-282-95154-8 010 $a9786612951541 010 $a90-04-18831-2 024 7 $a10.1163/ej.9789004180505.i-450 035 $a(CKB)2670000000065911 035 $a(EBL)635016 035 $a(OCoLC)695989913 035 $a(SSID)ssj0000443019 035 $a(PQKBManifestationID)11299713 035 $a(PQKBTitleCode)TC0000443019 035 $a(PQKBWorkID)10455818 035 $a(PQKB)10127277 035 $a(MiAaPQ)EBC635016 035 $a(OCoLC)457130353 035 $a(nllekb)BRILL9789004188310 035 $a(PPN)174388365 035 $a(Au-PeEL)EBL635016 035 $a(CaPaEBR)ebr10439068 035 $a(CaONFJC)MIL295154 035 $a(EXLCZ)992670000000065911 100 $a20091015d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Syrian wars$b[electronic resource] /$fby John D. Grainger 210 $aLeiden [Netherlands] ;$aBoston $cBrill$d2010 215 $a1 online resource (468 p.) 225 1 $aMnemosyne. Supplements. History and archaeology of classical antiquity,$x0169-8958 ;$vv. 320 300 $aDescription based upon print version of record. 311 $a90-04-18050-8 320 $aIncludes bibliographical references and index. 327 $aPrologue: Syria's importance revealed -- Syria divided -- Cold war -- The new kings, and the first Syrian war -- Competitive developing -- The second Syrian war -- Increasing strains -- The third war, the 'War of Laodike' -- The Seleukid collapse -- The fourth war -- The reversal, the Ptolemaic collapse -- The fifth war, the triumph of Antiochos III -- Changing priorities -- The sixth war, and the 'day of Eleusis' -- Mutual troubles and a new agenda -- The seventh war, the triumph of Ptolemy Philometor -- The legacy of Philometor -- The eighth war, the last chance for union -- The ninth, and last, war. 330 $aThis book examines the causes and courses of the series of wars in the Hellenistic period fought between the kingdom of the Seleukids and the Ptolemies over possession of Syria. This is a subject always mentioned by historians of the period in a glancing or abbreviated way, but which is actually wholly central to the development of both kingdoms and of the period as a whole. Other than relatively brief summaries no serious account has ever been produced. This extended consideration will bring to the centre of research on the Hellinistic period this long sequence of wars. Arguably they were the basic causes of the failure of both kingdoms in the face of Roman aggression and interference. 410 0$aMnemosyne, bibliotheca classica Batava.$pSupplementum ;$v320. 410 0$aMnemosyne, bibliotheca classica Batava.$pSupplementum.$pHistory and archaeology of classical antiquity. 606 $aSeleucids$xHistory 607 $aSyria$xHistory, Military 607 $aSyria$xHistory$y333 B.C.-634 A.D 608 $aElectronic books. 615 0$aSeleucids$xHistory. 676 $a939/.4304 700 $aGrainger$b John D.$f1939-$0255150 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459551403321 996 $aThe Syrian wars$91937325 997 $aUNINA LEADER 05257nam 2200613 450 001 9910787805003321 005 20230807204520.0 010 $a1-61705-178-0 035 $a(CKB)2670000000573350 035 $a(EBL)1827580 035 $a(SSID)ssj0001367598 035 $a(PQKBManifestationID)12538086 035 $a(PQKBTitleCode)TC0001367598 035 $a(PQKBWorkID)11444932 035 $a(PQKB)11058328 035 $a(MiAaPQ)EBC1827580 035 $a(Au-PeEL)EBL1827580 035 $a(CaPaEBR)ebr10962305 035 $a(CaONFJC)MIL655047 035 $a(OCoLC)894629983 035 $a(EXLCZ)992670000000573350 100 $a20150105h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCardiovascular genetics and genomics in clinical practice /$feditors, Sanjiv J. Shah, Donna K. Arnett 210 1$aNew York :$cdemosMEDICAL,$d2015. 210 4$dİ2015 215 $a1 online resource (326 p.) 300 $aDescription based upon print version of record. 311 $a1-62070-014-X 311 $a1-322-23767-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title; Copyright; Contents; Contributors; Preface; References; Video Captions; Share Cardiovascular Genetics and Genomics in Clinical Practice; Part I: Genetics and Genomics: The Basics; Chapter 1: Mendelian Genetics; Take Home Points; Mendel's Laws; Modes of Inheritance; Methods Used to Determine Modes of Inheritance; Clinical Utility of Genetic Information; Glossary; References; Chapter 2: Genetics of Complex Traits; Take Home Points; Quantitative Traits; Familial Aggregation; Measuring Familial Aggregation; Concordance Versus Discordance; Allele Sharing; Twin Studies 327 $aConcordance of MZ Versus DZ TwinsTwins Reared Apart; Limitations of Twin Studies; Heritability; Conclusions; References; Chapter 3: Genome-Wide Association Studies; Take Home Points; Why do we Need GWAS?; Genetic Basis of GWAS; Simple GWAS; Beyond GWAS Basics: Challenges and Limitations; Limitations of GWAS; Using GWAS Results; GWAS Success in Cardiovascular Disease; Summary; Glossary; References; Chapter 4: Bioinformatics; Take Home Points; Following Up on Linkage Analyses; Following Up on Genome-Wide Association Studies; Obtaining Information on Candidate Genes 327 $aCharacterizing DNA Variants Found within GenesReferences; Chapter 5: Epigenetics; Take Home Points; DNA Methylation; Histone Modifications; Challenges and Opportunities for Human CVD Epigenetic Studies; References; Chapter 6: MicroRNAs; Take Home Points; MicroRNA Structure and Function; MicroRNA and Cardiac Function; MicroRNA as Biomarkers; MicroRNA Therapeutics; Conclusions; References; Chapter 7: Gene Expression; Take Home Points; Microarray Technology; Quality Control; Data Normalization; Data Analysis; Ontology and Pathway Analysis; Validation and Meta-Analysis; Conclusions; References 327 $aChapter 8: Whole-Exome and Whole-Genome SequencingTake Home Points; Overview of Exome Chip, WES, and WGS Technologies; Available Strategies for the Conduct of WES Studies; Application of WES to Cardiovascular Disease; Next-Generation Sequencing Technologies for Clinical Diagnostics; Future Directions; Conclusions; References; Chapter 9: Gene-Environment Interactions; Take Home Points; Defining Interactions; Investigating Interactions: Study Design; Investigating Interactions: Statistical Power; Gene-Environment Interactions in Cardiovascular Disease 327 $aThe Promise and Challenges of Gene-Environment Interaction ResearchSummary; References; Chapter 10: Genetic Counseling; Take Home Points; Definition of Genetic Counseling; The Power of the Pedigree and Family Health History; Risk Assessment Beyond Basic Mendelian Principle; Psychosocial Counseling; Genetic Counselors in Cardiovascular Practice; Cardiovascular Genetic Testing; Partners in Practice; Conclusions; References; Part II: Genetics of Cardiovascular Disorders/Traits; Chapter 11: Blood Pressure Genomics; Take Home Points 327 $aCase Study: Severe Monogenic Hypertension-An Application of Whole-Exome Sequencing 330 $aCardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand ""primer"" of basic scientific concepts regarding cardiovascular genetics and genomics fol 606 $aHeart$xDiseases$xGenetic aspects 615 0$aHeart$xDiseases$xGenetic aspects. 676 $a616.1/2042 702 $aShah$b Sanjiv 702 $aArnett$b Donna K. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910787805003321 996 $aCardiovascular genetics and genomics in clinical practice$93674321 997 $aUNINA