LEADER 04258nam 2200805 a 450 001 9910459210603321 005 20200520144314.0 010 $a1-282-70626-8 010 $a9786612706264 010 $a0-226-73411-0 024 7 $a10.7208/9780226734118 035 $a(CKB)2670000000033512 035 $a(EBL)557584 035 $a(OCoLC)654029551 035 $a(SSID)ssj0000424086 035 $a(PQKBManifestationID)12164641 035 $a(PQKBTitleCode)TC0000424086 035 $a(PQKBWorkID)10468867 035 $a(PQKB)10686235 035 $a(SSID)ssj0000741551 035 $a(PQKBManifestationID)12361077 035 $a(PQKBTitleCode)TC0000741551 035 $a(PQKBWorkID)10720488 035 $a(PQKB)11010839 035 $a(StDuBDS)EDZ0000119123 035 $a(MiAaPQ)EBC557584 035 $a(DE-B1597)524178 035 $a(OCoLC)1135590470 035 $a(DE-B1597)9780226734118 035 $a(Au-PeEL)EBL557584 035 $a(CaPaEBR)ebr10405273 035 $a(CaONFJC)MIL270626 035 $a(EXLCZ)992670000000033512 100 $a20100825d2007 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNewcomers to old towns$b[electronic resource] $esuburbanization of the heartland /$fSonya Salamon ; with the collaboration of Karen Davis-Brown ... [et al.] 205 $aPbk. ed. 210 $aChicago $cUniversity of Chicago Press$d2007 215 $a1 online resource (270 p.) 300 $aDescription based upon print version of record. 311 $a0-226-73413-7 311 $a0-226-73412-9 320 $aIncludes bibliographical references (p. [225]-236) and index. 327 $apt. 1. Changes in the heartland -- pt. 2. Newcomers, old towns -- pt. 3. The postagrarian countryside. 330 $a2004 winner of the Robert E. Park Book Award from the Community and Urban Sociology Section (CUSS) of the American Sociological Association Although the death of the small town has been predicted for decades, during the 1990's the population of rural America actually increased by more than three million people. In this book, Sonya Salamon explores these rural newcomers and the impact they have on the social relationships, public spaces, and community resources of small town America. Salamon draws on richly detailed ethnographic studies of six small towns in central Illinois, including a town with upscale subdivisions that lured wealthy professionals as well as towns whose agribusinesses drew working-class Mexicano migrants and immigrants. She finds that regardless of the class or ethnicity of the newcomers, if their social status differs relative to that of oldtimers, their effect on a town has been the same: suburbanization that erodes the close-knit small town community, with especially severe consequences for small town youth. To successfully combat the homogenization of the heartland, Salamon argues, newcomers must work with oldtimers so that together they sustain the vital aspects of community life and identity that first drew them to small towns. An illustration of the recent revitalization of interest in the small town, Salamon's work provides a significant addition to the growing literature on the subject. Social scientists, sociologists, policymakers, and urban planners will appreciate this important contribution to the ongoing discussion of social capital and the transformation in the study and definition of communities. 606 $aUrban-rural migration$zMiddle West 606 $aUrban-rural migration$zIllinois$vCase studies 606 $aSociology, Rural$zMiddle West 606 $aSociology, Rural$zIllinois 607 $aMiddle West$xRural conditions 607 $aIllinois$xRural conditions 608 $aElectronic books. 615 0$aUrban-rural migration 615 0$aUrban-rural migration 615 0$aSociology, Rural 615 0$aSociology, Rural 676 $a307.72/0977 700 $aSalamon$b Sonya$0896940 701 $aDavis-Brown$b Karen$0896941 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459210603321 996 $aNewcomers to old towns$92004161 997 $aUNINA LEADER 04713nam 2200661Ia 450 001 9910778685003321 005 20230721023410.0 010 $a1-282-36844-3 010 $a9786612368448 010 $a0-470-46636-7 010 $a0-470-46635-9 035 $a(CKB)1000000000822085 035 $a(EBL)469409 035 $a(OCoLC)609848053 035 $a(SSID)ssj0000291823 035 $a(PQKBManifestationID)11238666 035 $a(PQKBTitleCode)TC0000291823 035 $a(PQKBWorkID)10253911 035 $a(PQKB)10289536 035 $a(MiAaPQ)EBC469409 035 $a(Au-PeEL)EBL469409 035 $a(CaPaEBR)ebr10346509 035 $a(CaONFJC)MIL236844 035 $a(EXLCZ)991000000000822085 100 $a20090210d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aClinical trials handbook$b[electronic resource] /$fedited by Shayne Cox Gad 210 $aHoboken, NJ $cWiley$dc2009 215 $a1 online resource (1247 p.) 225 1 $aPharmaceutical Development Series ;$vv.8 300 $aDescription based upon print version of record. 311 $a0-471-21388-8 320 $aIncludes bibliographical references and index. 327 $aClinical Trials Handbook; Contents; Preface; Contributors; 1 Introduction to Clinical Trials; 2 Regulatory Requirements for Investigational New Drug; 3 Preclinical Assessment of Safety in Human Subjects; 4 Predicting Human Adverse Drug Reactions from Nonclinical Safety Studies; 5.1 History of Clinical Trial Development and the Pharmaceutical Industry; 5.2 Adaptive Research; 6 Organization and Planning; 7 Process of Data Management; 8 Clinical Trials Data Management; 9.1 Clinical Trials and the Food and Drug Administration; 9.2 Phase I Clinical Trials; 9.3 Phase II Clinical Trials 327 $a9.4 Designing and Conducting Phase III Studies9.5 Phase IV: Postmarketing Trials; 9.6 Phase IV and Postmarketing Clinical Trials; 9.7 Regulatory Approval; 9.8 New Paradigm for Analyzing Adverse Drug Events; 10.1 Clinical Trials in Interventional Cardiology: Focus on XIENCE Drug-Eluting Stent; 10.2 Clinical Trials Involving Oral Diseases; 10.3 Dermatology Clinical Trials; 10.4 Emergency Clinical Trials; 10.5 Gastroenterology; 10.6 Gynecology Randomized Control Trials; 10.7 Special Population Studies (Healthy Patient Studies); 10.8 Musculoskeletal Disorders; 10.9 Oncology 327 $a10.10 Pharmacological Treatment Options for Nonexudative and Exudative Age-Related Macular Degeneration10.11 Paediatrics; 10.12 Clinical Trials in Dementia; 10.13 Clinical Trials in Urology; 10.14 Clinical Trials on Cognitive Drugs; 10.15 Bridging Studies in Pharmaceutical Safety Assessment; 10.16 Brief History of Clinical Trials on Viral Vaccines; 11 Methods of Randomization; 12 Randomized Controlled Trials; 13 Cross-Over Designs; 14.1 Biomarkers; 14.2 Biomarkers in Clinical Drug Development: Parallel Analysis of Alzheimer Disease and Multiple Sclerosis; 15 Review Boards 327 $a16 Size of Clinical Trials17 Blinding and Placebo; 18 Pharmacology; 19 Modeling and Simulation in Clinical Drug Development; 20 Monitoring; 21 Inference Following Sequential Clinical Trials; 22 Statistical Methods for Analysis of Clinical Trials; 23 Explanatory and Pragmatic Clinical Trials; 24.1 Ethics of Clinical Research in Durg Trials; 24.2 Ethical Issues in Clinical Research; 25 Regulations; 26 Future Challenges in Design and Ethics of Clinical Trials; 27 Proof-of-Principle/Proof-of-Concept Trials in Drug Development; Index 330 $aBest practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of 410 0$aPharmaceutical Development Series 606 $aDrugs$xTesting$vHandbooks, manuals, etc 606 $aClinical trials$vHandbooks, manuals, etc 615 0$aDrugs$xTesting 615 0$aClinical trials 676 $a615.1 676 $a615.580724 676 $a615/.1 701 $aGad$b Shayne C.$f1948-$096171 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910778685003321 996 $aClinical trials handbook$93791585 997 $aUNINA