LEADER 04779nam 22007212 450 001 9910459069503321 005 20151005020622.0 010 $a1-107-21533-1 010 $a0-511-85295-9 010 $a1-282-93173-3 010 $a9786612931734 010 $a0-511-93177-8 010 $a0-511-93043-7 010 $a0-511-93312-6 010 $a0-511-92792-4 010 $a0-511-93380-0 010 $a0-511-92538-7 035 $a(CKB)2670000000059936 035 $a(EBL)604989 035 $a(OCoLC)693761186 035 $a(SSID)ssj0000462677 035 $a(PQKBManifestationID)11346271 035 $a(PQKBTitleCode)TC0000462677 035 $a(PQKBWorkID)10409128 035 $a(PQKB)10429874 035 $a(UkCbUP)CR9780511933806 035 $a(MiAaPQ)EBC604989 035 $a(Au-PeEL)EBL604989 035 $a(CaPaEBR)ebr10436338 035 $a(CaONFJC)MIL293173 035 $a(EXLCZ)992670000000059936 100 $a20100928d2011|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe placenta and human developmental programming /$fedited by Graham J. Burton [and others]$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2011. 215 $a1 online resource (xi, 246 pages) $cdigital, PDF file(s) 225 0 $aCambridge medicine The placenta and human developmental programming 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-19945-X 320 $aIncludes index and bibliographical references. 327 $aCover; Half-title; Title; Copyright; Contents; Contributors; Preface; Chapter 1 Introduction; Chapter 2 The maternal and placental origins of chronic disease; Chapter 3 Pre-and periconceptual health and the HPA axis: Nutrition and stress; Chapter 4 Nutrition and preimplantation development; Chapter 5 Maternofetal transport pathways during embryogenesis and organogenesis; Chapter 6 Imprinted genes and placental growth: Implications for the developmental origins of health and disease 327 $aChapter 7 Genomic imprinting: Epigenetic control and potential roles in the developmental origins of postnatal health and diseaseChapter 8 Trophoblast invasion and uterine artery remodelling in primates; Chapter 9 The role of the maternal immune response in fetal programming; Chapter 10 Clinical causes and aspects of placental insufficiency; Chapter 11 Uterine blood flow as a determinant of fetoplacental development; Chapter 12 Placental amino acid transporters: The critical link between maternal nutrition and fetal programming? 327 $aChapter 13 Thematernal circulation and placental shape: Villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stressChapter 14 Glucocorticoids and placental programming; Chapter 15 Clinical biomarkers of placental development; Chapter 16 The placental roots of cardiovascular disease; Chapter 17 Placental function and later risk of osteoporosis; Chapter 18 Final general discussion; Chapter 19 The placenta and developmental programming: Some reflections; Index 330 $aDevelopmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine. 517 3 $aThe Placenta & Human Developmental Programming 606 $aPlacenta 606 $aFetus$xDevelopment 606 $aDevelopmental biology 615 0$aPlacenta. 615 0$aFetus$xDevelopment. 615 0$aDevelopmental biology. 676 $a573.67 702 $aBurton$b Graham$g(Graham J.), 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910459069503321 996 $aThe placenta and human developmental programming$92480592 997 $aUNINA