LEADER 03765oam 2200649I 450 001 9910459023403321 005 20200520144314.0 010 $a0-429-14677-9 010 $a1-4200-7350-8 024 7 $a10.1201/EBK1420073492 035 $a(CKB)2670000000035693 035 $a(EBL)565953 035 $a(OCoLC)660536815 035 $a(SSID)ssj0000410739 035 $a(PQKBManifestationID)11309157 035 $a(PQKBTitleCode)TC0000410739 035 $a(PQKBWorkID)10351518 035 $a(PQKB)11679618 035 $a(MiAaPQ)EBC565953 035 $a(Au-PeEL)EBL565953 035 $a(CaPaEBR)ebr10408382 035 $a(CaONFJC)MIL693918 035 $a(OCoLC)680620466 035 $a(EXLCZ)992670000000035693 100 $a20180331d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$a3D cell-based biosensors in drug discovery programs $emicrotissue engineering for high throughput screening /$fWilliam S. Kisaalita 210 1$aBoca Raton [Fla.] :$cCRC Press,$d2010. 215 $a1 online resource (392 p.) 300 $aDescription based upon print version of record. 311 $a1-4398-5904-3 311 $a1-322-62636-7 311 $a1-4200-7349-4 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Dedication; Contents; Preface; Author; Part I. Introduction; Chapter 1. Biosensors and Bioassays; Chapter 2. Target-Driven Drug Discovery; Part II. 3D versus 2D Cultures; Chapter 3. Comparative Transcriptional Profiling and Proteomics; Chapter 4. Comparative Structure and Function; Part III. Emerging Design Principles; Chapter 5. Chemical Microenvironmental Factors; Chapter 6. Spatial and Temporal Microenvironmental Factors; Chapter 7. Material Physical Property and Force Microenvironmental Factors; Chapter 8. Proteomics as a Promising Tool in the Search for 3D Biomarkers 327 $aChapter 9. Readout Present and Near FutureChapter 10. Ready-to-Use Commercial 3D Plates; Part IV. Technology Deployment Challenges and Opportunities; Chapter 11. Challenges to Adopting 3D Cultures in HTS Programs; Chapter 12. Cases for 3D Cultures in Drug Discovery; Chapter 13. Ideal Case Study Design; Appendix A: Patents for 3D Scaffolds; Appendix B: Current Drug Targets; Appendix C: Popular Cell Lines in Drug Discovery; Appendix D: Stem Cells in Drug Discovery; Back Cover 330 $aThis book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information--Provided by publisher. 606 $aPharmaceutical biotechnology 606 $aBiosensors 606 $aHigh throughput screening (Drug development) 608 $aElectronic books. 615 0$aPharmaceutical biotechnology. 615 0$aBiosensors. 615 0$aHigh throughput screening (Drug development) 676 $a615/.19 700 $aKisaalita$b William Ssempa$f1953,$0993114 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459023403321 996 $a3D cell-based biosensors in drug discovery programs$92274073 997 $aUNINA LEADER 01336nam 2200409I 450 001 9910711454203321 005 20181002160427.0 035 $a(CKB)5470000002483499 035 $a(OCoLC)1055419557 035 $a(EXLCZ)995470000002483499 100 $a20181002j201703 ua 0 101 0 $aeng 135 $aurmn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMorphological characterization of the frontal and parietal bones of the human skull /$fby Stephen L Alexander [and three others] 210 1$aAberdeen Proving Ground, MD :$cUS Army Research Laboratory,$dMar 2017. 215 $a1 online resource (x, 66 pages) $ccolor illustrations 225 1 $aARL-TR ;$v7962 300 $a"Mar 2017." 320 $aIncludes bibliographical references (pages 39-41). 606 $aSkull 606 $aTomography 606 $aMorphology 608 $aTechnical reports.$2lcgft 615 0$aSkull. 615 0$aTomography. 615 0$aMorphology. 700 $aAlexander$b Stephen L.$01416086 712 02$aU.S. Army Research Laboratory, 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910711454203321 996 $aMorphological characterization of the frontal and parietal bones of the human skull$93520162 997 $aUNINA LEADER 03272nam 22007093u 450 001 9910791078603321 005 20230207232309.0 010 $a1-4522-4888-5 035 $a(CKB)2550000001194187 035 $a(EBL)1598429 035 $a(SSID)ssj0001111976 035 $a(PQKBManifestationID)11665332 035 $a(PQKBTitleCode)TC0001111976 035 $a(PQKBWorkID)11157138 035 $a(PQKB)10783254 035 $a(MiAaPQ)EBC1598429 035 $a(EXLCZ)992550000001194187 100 $a20140127d1996|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFamilies & Time$b[electronic resource] $eKeeping Pace in a Hurried Culture 210 $aThousand Oaks $cSAGE Publications$d1996 215 $a1 online resource (271 p.) 225 1 $aUnderstanding Families series 300 $aDescription based upon print version of record. 311 $a1-322-42063-7 311 $a0-8039-7340-3 327 $aCover; Contents; Preface; Acknowledgments; Chapter 1 - Conceptualizations of Time; Chapter 2 - The Experience of Family Time in Historical Perspective; Chapter 3 - The Social Construction of Time in Families; Chapter 4 - Time Together: The Social Construction of Family Time; Chapter 5 - Controlling Family Time; Chapter 6 - The Politics of Time between Families and Society; Chapter 7 - Gender Politics of Family Time; Chapter 8 - Intergenerational Politics of Family Time; Chapter 9 - Toward an Integrated Theory of Family Time; Conclusion; References; Author Index; Subject Index 327 $aAbout the Author 330 $aWhat is family time? What value do we place on it? How many families today have time to be families? How do families view, use and seek to control time, and how successful are they at it? The concept of time is central to the study of families and is used in different ways: families changing through history; families experiencing the passage of time as they age over the life course; and families negotiating time for being together. Synthesizing these different concepts into a broad theory of how families understand time, Kerry J Daly examines time as a pervasive influence in the changing exper 410 0$aUnderstanding Families series 517 $aUnderstanding Families series 517 $aUnderstanding Families series, Volume 7 517 $aFamilies & Time 606 $aFamilies -- Sociological aspects 606 $aFamilies 606 $aTime -- Sociological aspects 606 $aFamilies$xSociological aspects 606 $aTime 606 $aSociology & Social History$2HILCC 606 $aSocial Sciences$2HILCC 606 $aFamily & Marriage$2HILCC 615 4$aFamilies -- Sociological aspects. 615 4$aFamilies. 615 4$aTime -- Sociological aspects. 615 0$aFamilies$xSociological aspects 615 0$aTime 615 7$aSociology & Social History 615 7$aSocial Sciences 615 7$aFamily & Marriage 676 $a306.85 700 $aDaly$b Kerry J$01493201 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910791078603321 996 $aFamilies & Time$93716068 997 $aUNINA