LEADER 01794nam 2200553 a 450 001 9910458929303321 005 20200520144314.0 010 $a1-60780-129-9 035 $a(CKB)2560000000010263 035 $a(EBL)535580 035 $a(OCoLC)645093457 035 $a(SSID)ssj0000671893 035 $a(PQKBManifestationID)11422864 035 $a(PQKBTitleCode)TC0000671893 035 $a(PQKBWorkID)10625742 035 $a(PQKB)10327745 035 $a(OCoLC)844080019 035 $a(MiAaPQ)EBC535580 035 $a(Au-PeEL)EBL535580 035 $a(CaPaEBR)ebr10389272 035 $a(EXLCZ)992560000000010263 100 $a20150403h20101993 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aArgentina$b[electronic resource] $ewomen in culture, business, & travel /$fWorld Trade Press 205 $a2nd ed. 210 $aPetaluma, Calif. $cWorld Trade Press$dc1993-2010 [2010] 215 $a1 online resource (8 p.) 300 $aCover title. 330 $aWomen often occupy different roles in a foreign culture. Avoid offensive assumptions and behavior by understanding the position of women in Argentinian society: their legal rights; access to education and health care; workforce participation; and their dating, marriage, and family life. 606 $aWomen$zArgentina 606 $aWomen travelers$zArgentina 606 $aBusinesswomen$zArgentina 608 $aElectronic books. 615 0$aWomen 615 0$aWomen travelers 615 0$aBusinesswomen 676 $a302.4209 676 $a305.42/09/05 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458929303321 996 $aArgentina$9737372 997 $aUNINA LEADER 05646nam 22007215 450 001 9910300208003321 005 20250709113221.0 010 $a1-4939-1393-X 024 7 $a10.1007/978-1-4939-1393-0 035 $a(CKB)3710000000291268 035 $a(EBL)1968238 035 $a(OCoLC)896824700 035 $a(SSID)ssj0001386808 035 $a(PQKBManifestationID)11884114 035 $a(PQKBTitleCode)TC0001386808 035 $a(PQKBWorkID)11374491 035 $a(PQKB)10174111 035 $a(DE-He213)978-1-4939-1393-0 035 $a(MiAaPQ)EBC1968238 035 $a(PPN)183098021 035 $a(EXLCZ)993710000000291268 100 $a20141120d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTargeted Therapy of Acute Myeloid Leukemia /$fedited by Michael Andreeff 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (804 p.) 225 1 $aCurrent Cancer Research,$x2199-2592 300 $aDescription based upon print version of record. 311 08$a1-4939-1392-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction/Perspective -- Genetics and Classification of Acute Myeloid Leukemia -- Proteomics of AML to guide Selection of Therapy -- Roles of Apoptosis Regulating Bcl-2-Family Genes in AML -- Bcl-2 family: Translational aspects -- IAP Family and Proteins as Therapeutic Targets for Acute Myeloid Leukemia -- TP53 Mutations in Acute Myeloid Leukemia -- Targeting p53 Tumor Suppressor for AML Therapy -- AML-Selective Apoptosis Induction by rationally designed Death Ligand Fusion Protein -- PIM Kinases in AML -- Development of Midostaurin as a Tyrosine Kinase Inhabitor -- FLT3 in AML -- FLT3-ITD. Clinical (Sorafenib/AC220) -- Nucleophosmin (NPM1) -- Raf/MEK Pathway -- The Role of Translational Medicine in Optimization of Therapies targeting the RAS-MAP Kinase Pathway -- Clinical Use of Farnesyltransferase Inhititors -- The P13K-AKT-mTOR signaling Network in AML -- Targeting the P13 Kinase-mTOR Signaling Pathway in AML -- Aurora kinases -- The Clinical Development of Aurora Kinase Inhibitors in Acute Myeloid Leukemia -- AML-Deacetylases -- Methylation in AML-Clinical Applications -- Topic: RARa/RXR  Part: Basic -- Arsenic Trioxide in Untreated APL -- Targeting PML-RAR? with Retinoids -- NR4A Orphan Receptors as Drug Targets -- Antibody-based Therapeutics Targeting CD33, CD45, and CD66 -- New Heterogeneity of the Leukemic Stem Cells -- Targeting Leukemia Stem Cells -- Regulation of Hematopoiesis by CXCL12/CXCR4 Signaling -- CXC4/CXCL12 as a Therapeutic Target -- VLA-4: A Cell?s Consequential Encounter -- VLA-4 Function and Prognosis in Acute Myeloid Leukemia -- VLA4 in Acute Lymphoblastic Leukemia -- The Leukemic Bone Marrow Microenvironment: Targeting Hypoxia with Hypoxia Activated Pro-Drugs -- Topic: miRs as Therapeutic Targets -- Clinical Implications of MicroRNAs in AML -- Inhibition of Glycolysis as a Therapeutic Strategy in Acute Myeloid Leukemias -- Molecular and Biochemical Basis for the Reprogramming of Intermediary Metabolism in Leukemia Cells -- NK Cell Immunotherapy for AML -- Allogeneicand Autologous T cell Strategies to Enhance Targeting of Acute Myeloid Leukemia -- Indications for Hematopoietic Transplantation for AML -- Mesenchymal Stem/Stromal Cell Targeted Therapies for Solid Tumors and Hematological Malignancies. 330 $aThis book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. 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Internet/Web, and HCI,$x2946-1642 ;$v10038 311 08$a9783319483344 311 08$a331948334X 320 $aIncludes bibliographical references and index. 327 $aMedical/health/biomedicine information resources such as patient medical records, devices and equipments, software and tools to capture, store, retrieve, process, analyze, and optimize the use of information in the health domain -- Data management, data mining, and knowledge discovery, all of which play a key role in decision making, management of public health, examination of standards, privacy and security issues -- Computer visualization and artificial intelligence for computer aided diagnosis; development of new architectures and applications for health information systems. 330 $aThis book constitutes the refereed proceedings of the 5th International Conference on Health Information Science, HIS 2016, held in Shanghai, China, in November 2016. 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Internet/Web, and HCI,$x2946-1642 ;$v10038 606 $aMedical informatics 606 $aApplication software 606 $aData mining 606 $aArtificial intelligence 606 $aInformation storage and retrieval systems 606 $aHealth Informatics 606 $aComputer and Information Systems Applications 606 $aData Mining and Knowledge Discovery 606 $aArtificial Intelligence 606 $aInformation Storage and Retrieval 615 0$aMedical informatics. 615 0$aApplication software. 615 0$aData mining. 615 0$aArtificial intelligence. 615 0$aInformation storage and retrieval systems. 615 14$aHealth Informatics. 615 24$aComputer and Information Systems Applications. 615 24$aData Mining and Knowledge Discovery. 615 24$aArtificial Intelligence. 615 24$aInformation Storage and Retrieval. 676 $a610.285 702 $aYin$b Xiaoxia$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGeller$b James$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLi$b Ye$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZhou$b Rui$c(Computer scientist),$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWang$b Hua$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZhang$b Yanchun$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483744803321 996 $aHealth Information Science$91934688 997 $aUNINA