LEADER 05419nam 2200697Ia 450 001 9910458813803321 005 20200520144314.0 010 $a1-281-11191-0 010 $a9786611111915 010 $a0-08-055619-1 035 $a(CKB)1000000000383521 035 $a(EBL)328555 035 $a(OCoLC)476125905 035 $a(SSID)ssj0000121684 035 $a(PQKBManifestationID)11135463 035 $a(PQKBTitleCode)TC0000121684 035 $a(PQKBWorkID)10111198 035 $a(PQKB)10287899 035 $a(PPN)182565440 035 $a(MiAaPQ)EBC328555 035 $a(Au-PeEL)EBL328555 035 $a(CaPaEBR)ebr10204244 035 $a(CaONFJC)MIL111191 035 $a(EXLCZ)991000000000383521 100 $a20080328d2007 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe cholesterol wars$b[electronic resource] $ethe skeptics vs. the preponderance of evidence /$fDaniel Steinberg 205 $a1st ed. 210 $aSan Diego, Calif. $cAcademic Press$d2007 215 $a1 online resource (253 p.) 300 $aDescription based upon print version of record. 311 $a0-12-373979-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; The Cholesterol Wars: The Skeptics vs. the Preponderance of Evidence; Copyright Page; Contents; Foreword; Preface; Acknowledgments; Chapter 1. Overview; On the nature of medical controversy; An overview of the cholesterol wars; Where we stand today; References; Chapter 2. Animal Models of Atherosclerosis; Nikolai N. Anitschkow and the cholesterol-fed rabbit; Why wasn't Anitschkow's lead followed up?; What led Anitschkow to feed rabbits cholesterol?; Atherosclerosis in other species; Notes; References 327 $aChapter 3. Hypercholesterolemia and Atherosclerosis in Humans: Causally Related? The clinical and genetic evidence; Do more modest degrees of hypercholesterolemia, such as are found in a general population, confer risk of premature coronary heart disease?; The epidemiologic evidence; Dietary fat, blood cholesterol, and coronary heart disease; Do diets rich in saturated fats really raise blood cholesterol?; Experimental findings; Observational studies; The contribution of dietary cholesterol intake; Early clinical trials of dietary intervention; Additional pre-1970 studies 327 $aOverview of all of the pre-1970's diet intervention studies A brief wrap-up of the case against cholesterol as of 1970; Note; References; Chapter 4. Building the Basic Science Foundation; The biosynthesis of cholesterol and its metabolic regulation; The rate-limiting step, HMGCo A reductase; The birth of the lipoproteins and the John W. Gofman story; Unraveling the complex metabolism and interactions of the plasma lipoproteins; Which lipoproteins are proatherogenic?; The National Heart Institute story; Bringing the lipoprotein package concept into clinical practice 327 $aMoving from phenotype to genotypeReferences; Chapter 5. In Search of a Pathogenesis; The importance of understanding mechanism in gaining acceptance of a hypothesis; Early attempts to define the pathogenesis of atherosclerosis; The response-to-injury hypothesis and the monoclonal hypothesis; Understanding the role of HDL as an atheroprotective factor; An update on HDL as a target for intervention; Discovery of the LDL receptor: the remarkable partnership of Brown and Goldstein; Goldstein and Brown start their search for the faulty gene in familial hypercholesterolemia 327 $aDiscovery of the scavenger receptor on macrophages Oxidatively modified LDL and atherogenesis; Inflammation in the pathogenesis of atherosclerosis; Weighing the relative importance of inflammation and hyperlipidemia; Regression of atherosclerosis; Status of the lipid hypothesis in the 1980's; Note; References; Chapter 6. The Search for Cholesterol-lowering Drugs; Hypocholesterolemic drugs as a target: cons and pros Nicotinic acid; Bile acid-binding resins; Clofibrate; Probucol; Another blow: the somewhat messy Coronary Drug Project; The cholesterol controversy at its height; References 327 $aChapter 7. The 1984 Coronary Primary Prevention Trial 330 $aToday, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future. 606 $aAtherosclerosis 606 $aAnticholesteremic agents 606 $aStatins (Cardiovascular agents) 608 $aElectronic books. 615 0$aAtherosclerosis. 615 0$aAnticholesteremic agents. 615 0$aStatins (Cardiovascular agents) 676 $a616.1/36 676 $a616.136061 700 $aSteinberg$b Daniel$f1922-$0868735 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458813803321 996 $aThe cholesterol wars$91939278 997 $aUNINA LEADER 01597nam 2200337Ia 450 001 996386115303316 005 20200824132701.0 035 $a(CKB)4940000000079923 035 $a(EEBO)2240854140 035 $a(OCoLC)ocm13044891e 035 $a(OCoLC)13044891 035 $a(EXLCZ)994940000000079923 100 $a19860121d1695 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 02$aA pattern of a well-constituted and well-governed hospital, or, A brief description of the building, and full relation of the establishment, constitution, discipline, oeconomy and administration of the government of the Royal Hospital of the Invalids, near Paris$b[electronic resource] /$fpartly translated from a large book printed some years ago in French ; and partly extracted out of some other manuscript relations never before published 210 $aLondon $cPrinted for Richard Baldwin ...$d1695 215 $a[12], xix, 170, [6] p 300 $aMarginal notes. 300 $aReproduction of original in University of Alabama Library. 330 $aeebo-0163 606 $aHospitals$zFrance$xAdministration 615 0$aHospitals$xAdministration. 801 0$bEAA 801 1$bEAA 801 2$bm/c 801 2$bWaOLN 906 $aBOOK 912 $a996386115303316 996 $aA pattern of a well-constituted and well-governed hospital, or, A brief description of the building, and full relation of the establishment, constitution, discipline, oeconomy and administration of the government of the Royal Hospital of the Invalids, near Paris$92314039 997 $aUNISA