LEADER 05175nam 2200697Ia 450 001 9910458744303321 005 20200520144314.0 010 $a1-281-02870-3 010 $a9786611028701 010 $a0-08-053521-6 035 $a(CKB)1000000000364766 035 $a(EBL)306685 035 $a(OCoLC)162128696 035 $a(SSID)ssj0000183545 035 $a(PQKBManifestationID)11179798 035 $a(PQKBTitleCode)TC0000183545 035 $a(PQKBWorkID)10196558 035 $a(PQKB)10351020 035 $a(MiAaPQ)EBC306685 035 $a(PPN)182571661 035 $a(Au-PeEL)EBL306685 035 $a(CaPaEBR)ebr10188187 035 $a(CaONFJC)MIL102870 035 $a(EXLCZ)991000000000364766 100 $a19991022d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aIon channels and disease$b[electronic resource] $echannelopathies /$fFrances M. Ashcroft 210 $aSan Diego $cAcademic Press$d1999 215 $a1 online resource (505 p.) 225 1 $aQuantitative Finance 300 $aDescription based upon print version of record. 311 $a0-12-065310-9 327 $aFront Cover; Ion Channels and Disease; Copyright Page; CONTENTS; PREFACE; CHAPTER 1. INTRODUCTION; CHAPTER 2. FROM GENE TO PROTEIN; Basic Genetics; CHAPTER 3. HOW ION CHANNELS WORK; Properties of Single-Channel Currents; From Single Channels to Macroscopic Currents; From Whole-Cell Currents to Membrane Potential Changes; CHAPTER 4. STUDYING ION CHANNELS; Investigating Ion Channel Function; Obtaining the Primary Sequence; Investigating Ion Channel Structure; Genetic Analysis of Ion Channels and Disease; CHAPTER 5. VOLTAGE-GATED Na+ CHANNELS; Diseases of Muscle Na+ Channels 327 $aDiseases of Neuronal Na+ ChannelsCHAPTER 6. VOLTAGE-GATED K+ CHANNELS; KV Channels; KV Channels and Disease; KCNQ Channels; KCNQ Channels and Disease; Eag-Like KV Channels; Eag-like KV Channels and Disease; CHAPTER 7. Ca2+-ACTIVATED K+ CHANNELS; Maxi KCa (BK) Channels; Small KCa Channels; Myotonic Muscular Dystrophy; Intermediate KCa Channels; CHAPTER 8. INWARDLY RECTIFYING K+ CHANNELS; Diseases Associated with Kir Channels; CHAPTER 9. VOLTAGE-GATED Ca2+ CHANNELS; Diseases of Skeletal Muscle Ca2+ Channels; Diseases of Neuronal Calcium Channels; CHAPTER 10. VOLTAGE-GATED CL- CHANNELS 327 $aCl- Channel DiseasesCHAPTER 11. CYCLIC NUCLEOTIDE-GATED CHANNELS; Cyclic Nucleotide-Gated Channels; CNG Channel Mutations Associated with Disease; Hyperpolarization-Activated Cyclic-Nucleotide- Gated Channels; CHAPTER 12. CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; Cystic Fibrosis; CHAPTER 13. EPITHELIAL Na+ CHANNEL; Diseases Associated with ENaC Channels; CHAPTER 14. LIGAND-GATED Ca2+ CHANNELS; Ryanodine Receptors; Diseases Associated with Ryanodine; IP3 Receptors; Diseases Associated with IP3 Receptors; CHAPTER 15. ACETYLCHOLINE RECEPTORS; Diseases of Skeletal Muscle AChRs 327 $aDiseases of Neuronal AChRCHAPTER 16. GLUTAMATE RECEPTORS; Non-NMDA Receptors; NMDA Receptors; Glutamate Channels and Disease; CHAPTER 17. GLYCINE RECEPTORS; Glycine Receptors and Disease; CHAPTER 18. GABAA RECEPTORS; Diseases Associated with GABAA Channels; CHAPTER 19. WATER CHANNELS; CHAPTER 20. GAP JUNCTION CHANNELS; Diseases of Gap Junction Channels; CHAPTER 21. AUTOANTIBODIES TO ION CHANNELS; Basic Immunology; Autoantibodies Affecting Neuromuscular Transmission; Autoantibodies to Ion Channels Not Involved in Neuromuscular Transmission; CHAPTER 22. ION CHANNELS IN VIRUSES; Influenza Virus 327 $aOther Types of VirusesCHAPTER 23. ION CHANNELS AS LETHAL AGENTS; Ion Channels of the Vertebrate Immune System; Ion Channels of Bacteria, Fungi and Protozoans; Venoms; CHAPTER 24. A RAGBAG OF CHANNELS; ATP-Gated Ion Channels; Vanilloid Receptors; Channels Involved in Programmed Cell Death; ß-Amyloid Peptide; A LAST WORD; BIBLIOGRAPHY; INDEX 330 $aIon channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of i 410 0$aQuantitative Finance 606 $aIon channels 606 $aGenetic disorders$xMolecular aspects 606 $aMembrane proteins 608 $aElectronic books. 615 0$aIon channels. 615 0$aGenetic disorders$xMolecular aspects. 615 0$aMembrane proteins. 676 $a571.64 676 $a616.07 676 $a616.07 21 700 $aAshcroft$b Frances M$0764712 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458744303321 996 $aIon channels and disease$91553317 997 $aUNINA