LEADER 05535nam 2200673Ia 450 001 9910458738903321 005 20200520144314.0 010 $a1-280-64130-4 010 $a9786610641307 010 $a0-08-045615-4 035 $a(CKB)1000000000364736 035 $a(EBL)269985 035 $a(OCoLC)476000565 035 $a(SSID)ssj0000221664 035 $a(PQKBManifestationID)12057085 035 $a(PQKBTitleCode)TC0000221664 035 $a(PQKBWorkID)10161024 035 $a(PQKB)11223076 035 $a(MiAaPQ)EBC269985 035 $a(Au-PeEL)EBL269985 035 $a(CaPaEBR)ebr10138177 035 $a(CaONFJC)MIL64130 035 $a(OCoLC)469388349 035 $a(PPN)134284682 035 $a(EXLCZ)991000000000364736 100 $a20051005d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPhysiology of the gastrointestinal tract$b[electronic resource] /$feditor-in-chief, Leonard R. Johnson ; associate editors, Kim Barrett ... [et al.] 205 $a4th ed. 210 $aAmsterdam ;$aBoston $cElsevier Academic Press$dc2006 215 $a1 online resource (2098 p.) 300 $aDescription based upon print version of record. 311 $a0-12-088394-5 320 $aIncludes bibliographical references and index. 327 $afront cover; Volume 1; copyright; table of contents; Volume 1 Contents; front matter; Volume 1 Contributors; Volume 1 Preface to the First Edition; Volume 1 Preface; Volume 1 Acknowledgments; body; 1 Transcriptional and Epigenetic Regulation; OVERVIEW OF GENE ORGANIZATION; EPIGENETIC INFLUENCES; ANATOMY OF THE PROMOTER; METHODOLOGY; TRANSCRIPTIONAL CONTROL OF GASTROINTESTINAL PEPTIDES; POSTTRANSCRIPTIONAL PROCESSING; TRANSPORT ACROSS THE NUCLEAR MEMBRANE; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 2 Translation and Posttranslational Processing of Gastrointestinal Peptides; TRANSLATION 327 $aPOSTTRANSLATIONAL PROCESSINGTRANSPORT INTO THE ENDOPLASMIC RETICULUM; PROCESSING IN THE ENDOPLASMIC RETICULUM; TRANSPORT FROM THE ENDOPLASMIC RETICULUM AND THROUGH THE GOLGI; PROCESSING REACTIONS IN THE GOLGI; FORMATION OF SECRETORY VESICLES; PROCESSING REACTIONS IN THE SECRETORY VESICLE; POSTTRANSLATIONAL PROCESSING OF PREPROGASTRIN; REFERENCES; 3 Transmembrane Signaling by G Protein-Coupled Receptors; STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS; MECHANISMS OF SIGNAL TRANSDUCTION; RECEPTOR TYROSINE KINASES ARE SIGNALING PARTNERS FOR G PROTEIN-COUPLED RECEPTORS 327 $aMECHANISMS THAT REGULATE SIGNALING BY G PROTEIN-COUPLED RECEPTORSCONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 4 Gastrointestinal Hormones: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin; GASTRIN; CHOLECYSTOKININ; SOMATOSTATIN; GHRELIN; REFERENCES; 5 Postpyloric Gastrointestinal Peptides; SECRETIN; INTESTINAL SOMATOSTATIN; VASOACTIVE INTESTINAL POLYPEPTIDE AND RELATED PEPTIDES; NEUROTENSIN; NEUROPEPTIDE Y; MOTILIN; PEPTIDE YY; REFERENCES; 6 Gastrointestinal Peptide Hormones Regulating Energy and Glucose Homeostasis; PROGLUCAGON GENE STRUCTURE AND THE PROGLUCAGON-DERIVED PEPTIDES 327 $aPROGLUCAGON-DERIVED PEPTIDE METABOLISM AND CLEARANCEGLUCAGON RECEPTOR FAMILY; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCAGON-LIKE PEPTIDE-2 RECEPTOR; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR; BIOLOGICAL ACTIONS OF GLUCAGON; GLUCAGON ADMINISTRATION IN HUMAN SUBJECTS; BIOLOGICAL ACTIONS OF GLICENTIN; OXYNTOMODULIN; BIOLOGICAL ACTIONS OF GLUCAGONLIKE PEPTIDE-1; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS AND THE TREATMENT OF TYPE 2 DIABETES; ENHANCING INCRETIN ACTION VIA INHIBITION OF DIPEPTIDYL PEPTIDASE-IV; BIOLOGICAL ACTIONS OF GLUCAGONLIKE PEPTIDE-2 327 $aGLUCAGON-LIKE PEPTIDE-2 ADMINISTRATION TO HUMAN SUBJECTSGLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; REFERENCES; 7 Growth Factors in the Gastrointestinal Tract; INTRODUCTION; TRANSFORMING GROWTH FACTOR-? FAMILY OF PEPTIDES AND RECEPTORS; EPIDERMAL GROWTH FACTOR FAMILY OF PEPTIDES AND RECEPTORS; INSULIN-LIKE GROWTH FACTORS; TREFOIL FACTOR FAMILY OF PEPTIDES; HEPATOCYTE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR FAMILY; REFERENCES; 8 Developmental Signaling Networks; HISTORY; Wnt/?-CATENIN PATHWAY; NONCANONICAL WNT SIGNALING PATHWAYS; WNT/?-CATENIN PATHWAY IN GASTROINTESTINAL PHYSIOLOGY 327 $aWNT/?-CATENIN PATHWAY DEFECTS IN GASTROINTESTINAL TUMORS 330 $aFROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tract?to collect in one set of volumes the most current and comprehensive knowledge in our field?was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled ""Basic Cell Physiology and Growth of the Gl Tract"" contains numerous new chapters o 606 $aGastrointestinal system$xPhysiology 606 $aDigestive organs$xPhysiology 608 $aElectronic books. 615 0$aGastrointestinal system$xPhysiology. 615 0$aDigestive organs$xPhysiology. 676 $a612.3/2 701 $aJohnson$b Leonard R.$f1942-$0101156 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458738903321 996 $aPhysiology of the gastrointestinal tract$92273730 997 $aUNINA