LEADER 05473nam 22006854a 450 001 9910458719103321 005 20200520144314.0 010 $a1-281-00500-2 010 $a9786611005009 010 $a0-08-049135-9 035 $a(CKB)1000000000364600 035 $a(EBL)294602 035 $a(OCoLC)437181606 035 $a(SSID)ssj0000158874 035 $a(PQKBManifestationID)11151355 035 $a(PQKBTitleCode)TC0000158874 035 $a(PQKBWorkID)10171356 035 $a(PQKB)10052660 035 $a(MiAaPQ)EBC294602 035 $a(PPN)130936294 035 $a(Au-PeEL)EBL294602 035 $a(CaPaEBR)ebr10186436 035 $a(CaONFJC)MIL100500 035 $a(EXLCZ)991000000000364600 100 $a20030523d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFrom molecules to networks$b[electronic resource] $ean introduction to cellular and molecular neuroscience /$fedited by John H. Byrne, James L. Roberts 210 $aAmsterdam ;$aBoston $cElsevier Academic Press$dc2004 215 $a1 online resource (599 p.) 300 $aDescription based upon print version of record. 311 $a0-12-148660-5 320 $aIncludes bibliographical references and index. 327 $aFront Cover; From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience; Copyright Page; Full Contents; Contributors; Preface; Chapter 1. Cellular Components of Nervous Tissue; The Neuron; The Neuroglia; The Cerebral Vasculature; Chapter 2. Subcellular Organization of the Nervous System: Organelles and Their Functions; Axons and Dendrites: Unique Structural Components of Neurons; Protein Synthesis in Nervous Tissue; The Cytoskeletons of Neurons and Glial Cells; Molecular Motors in the Nervous System; Building and Maintaining Nervous System Cells 327 $aChapter 3. Brain Energy MetabolismEnergy Metabolism of the Brain as a Whole Organ; Tight Coupling of Neuronal Activity, Blood Flow, and Energy Metabolism; Energy-Producing and Energy-Consuming Processes in the Brain; Brain Energy Metabolism at the Cellular Level; Glutamate and Nitrogen Metabolism: A Coordinated Shuttle Between Astrocytes and Neurons; The Astrocyte-Neuron Metabolic Unit; Chapter 4. Electrotonic Properties of Axons and Dendrites; Spread of Steady-State Signals; Spread of Transient Signals; Electrotonic Properties Underlying Propagation in Axons; Electrotonic Spread in Dendrites 327 $aDynamic Properties of Passive Electrotonic StructureRelating Passive to Active Potentials; Chapter 5. Membrane Potential and Action Potential; The Membrane Potential; The Action Potential; Chapter 6. Molecular Properties of Ion Channels; Families of Ion Channels; Channel Gating; Ion Permeation; Ion Channel Distribution; Summary; Chapter 7. Dynamical Properties of Excitable Membranes; The Hodgkin-Huxley Model; A Geometric Analysis of Excitability; Chapter 8. Release of Neurotransmitters; Organization of the Chemical Synapse; Excitation-Secretion Coupling 327 $aThe Molecular Mechanisms of the Nerve TerminalQuantal Analysis; Short-Term Synaptic Plasticity; Chapter 9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters; Diverse Modes of Neuronal Communication; Chemical Transmission; Classic Neurotransmitters; Summary; Chapter 10. Nonclassic Signaling in the Brain; Peptide Neurotransmitters; Neurotensin as an Example of Peptide Neurotransmitters; Unconventional Transmitters; Synaptic Transmitters in Perspective; Chapter 11. Neurotransmitter Receptors; Ionotropic Receptors; G Protein-Coupled Receptors 327 $aChapter 12. Intracellular SignalingSignaling Through G-Protein-Linked Receptors; Modulation of Neuronal Function by Protein Kinases and Phosphatases; Chapter 13. Regulation of Neuronal Gene Expression and Protein Synthesis; Intracellular Signaling Affects Nuclear Gene Expression; Role of cAMP and Ca2+ in the Activation Pathways of Transcription; Summary; Chapter 14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways; Methods for Modelling Intracellular Signaling Pathways; General Issues in the Modeling of Biochemical Systems; Specific Modeling Methods; Summary 327 $aChapter 15. Cell-Cell Communication: An Overview Emphasizing Gap Junctions 330 $aAn understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.* Highly referenced for readers to pursue topics of interest in greater detail* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks* Richly ill 606 $aMolecular neurobiology 606 $aCytology 606 $aNeurons 608 $aElectronic books. 615 0$aMolecular neurobiology. 615 0$aCytology. 615 0$aNeurons. 676 $a611/.0188 701 $aByrne$b John H$0133425 701 $aRoberts$b James Lewis$f1951-$0879553 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458719103321 996 $aFrom molecules to networks$91964069 997 $aUNINA