LEADER 05247nam 2200649Ia 450 001 9910458636203321 005 20200520144314.0 010 $a1-281-03719-2 010 $a9786611037192 010 $a0-08-054618-8 035 $a(CKB)1000000000364135 035 $a(EBL)299463 035 $a(OCoLC)476077351 035 $a(SSID)ssj0000204935 035 $a(PQKBManifestationID)11171147 035 $a(PQKBTitleCode)TC0000204935 035 $a(PQKBWorkID)10189761 035 $a(PQKB)11305202 035 $a(MiAaPQ)EBC299463 035 $a(Au-PeEL)EBL299463 035 $a(CaPaEBR)ebr10186787 035 $a(CaONFJC)MIL103719 035 $a(EXLCZ)991000000000364135 100 $a20070628d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular neurology$b[electronic resource] /$fStephen Waxman 210 $aBurlington, MA $cElsevier Academic Press$dc2007 215 $a1 online resource (597 p.) 300 $aDescription based upon print version of record. 311 $a0-12-369509-0 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Molecular Neurology; Copyright Page; Contents; Contributor's List; Preface; Section I: Principles of Molecular Neurology; Chapter 1: Genetics as a Tool in Neurology; I. Introduction; II. Structure and Function of Genes and Chromosomes; III. Genetic Medicine; IV. The Neurogenetic Evaluation; V. Identification of Human Disease Genes; VI. Methods for Human Molecular Genetic Analysis; VII. Treatment of Genetic Diseases; References; Chapter 2: Neurology and Genomic Medicine; I. Introduction; II. Basic Concepts; III. The Human Genome Project (HGP) and Haplotype Mapping (HapMap) Project 327 $aIV. Family HistoryV. Genetic Mechanisms; VI. Pharmacogenetics; VII. Gene-Gene and Gene-Environment Interactions; VIII. Comparative Genomic Hybridization (CGH); IX. Mitochondria and the Mitochondrial Genome (mtDNA); X. Summary; References; Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System; I. Introduction; II. Structure and Functions of Mitochondria; III. Mitochondria in Mechanisms of Neuronal Cell Death and Neurological Disease; IV. Roles of Mitochondrial Dysfunction in Common Neurodegenerative Diseases; V. Conclusions; References 327 $aCahpter 4: Neuronal Channels and ReceptorsI. Introduction; II. Nomenclature; III. Structure and Function; IV. Physiological Roles; V. Neurological Disorders Caused by Channelopathies; References; Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System; I. Introduction; II. Role of Molecular Chaperones in Protein Folding Quality Control; III. Regulation of Chaperone Expression: The Heat Shock Response; IV. Role of Molecular Chaperones in Neurodegenerative Diseases; V. Chaperone Hypotheses; VI. Therapeutic Avenues; References 327 $aChapter 6: Metabolic Biopsy of the BrainI. Phosphorus Magnetic Resonance Spectroscopy; II. The Phosphocreatine Shuttle Hypothesis; III. Magnetization Transfer Measurements of ATP and Phosphocreatine Synthesis; IV. Hydrogen (Proton) Spectroscopy; V. Carbon Spectroscopy; VI. MR Spectroscopic Measurements of Cerebral Lactate; VII. The Astrocyte-Neuron Lactate Shuttle Hypothesis; VIII. Cerebral Ammonia Metabolism; IX. Summary; References; Chapter 7: Gene Therapy Approaches in Neurology; I. Why Use Gene Transfer in the Development of Novel Therapies?; II. Gene Transfer Strategies 327 $aIII. Development of Neurological Gene TherapyIV. Conclusions-Future Developments; References; Chapter 8: Programmed Cell Death and Its Role in Neurological Disease; I. Introduction: Neurologists and Cell Death; II. Cell Death: History and Classification; III. Current Status of Programmed Cell Death Studies; IV. Trophic Factors and the Concept of Cellular Dependence; V. Apoptosis Induced by Unfolded, Misfolded, or Alternatively Folded Proteins; VI. Does Programmed Cell Death Play a Role in Neurodegeneration? 327 $aVII. Are Programmed Cell Death Pathways Appropriate Therapeutic Targets in Neurodegeneration? 330 $aWhy a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlyin 606 $aMolecular neurobiology 606 $aMolecular biology 608 $aElectronic books. 615 0$aMolecular neurobiology. 615 0$aMolecular biology. 676 $a573.84 676 $a616.8 700 $aWaxman$b Stephen G$0628462 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458636203321 996 $aMolecular neurology$92249869 997 $aUNINA