LEADER 05416nam 2200673Ia 450 001 9910458618103321 005 20200520144314.0 010 $a1-280-72895-7 010 $a9786610728954 010 $a0-08-046646-X 035 $a(CKB)1000000000364083 035 $a(EBL)281967 035 $a(OCoLC)162131324 035 $a(SSID)ssj0000288966 035 $a(PQKBManifestationID)11232486 035 $a(PQKBTitleCode)TC0000288966 035 $a(PQKBWorkID)10383425 035 $a(PQKB)10299966 035 $a(MiAaPQ)EBC281967 035 $a(Au-PeEL)EBL281967 035 $a(CaPaEBR)ebr10155881 035 $a(CaONFJC)MIL72895 035 $a(EXLCZ)991000000000364083 100 $a20071205d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAppetite and body weight$b[electronic resource] $eintegrative systems and the development of anti-obesity drugs /$fedited by Tim C. Kirkham and Steven J. Cooper 210 $aAmsterdam ;$aBoston $cElsevier Academic Press$dc2007 215 $a1 online resource (385 p.) 300 $aDescription based upon print version of record. 311 $a0-12-370633-5 320 $aIncludes bibliographical references and index. 327 $aFront cover; APPETITE AND BODY WEIGHT; Copyright page; Table of Contents; Contributors; CHAPTER 1: Introduction and Overview; CHAPTER 2: Cortical Systems Involved in Appetite and Food Consumption; I. INTRODUCTION; II. FOOD MOTIVATION; III. CORTICAL REPRESENTATIONS OF SENSORY INPUTS; IV. CONCLUSION; Acknowledgments; References; CHAPTER 3: The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems Regulating Food Intake; I. INTRODUCTION; II. THE REGULATION OF FEEDING BEHAVIOR BY THE NUCLEUS ACCUMBENS SHELL 327 $aIII. AFFERENT PROJECTIONS TO THE AcbSh THAT MAY BE INVOLVED IN REGULATING FOOD INTAKEIV. DOWNSTREAM COMPONENTS OF THE FUNCTIONAL AcbSh FEEDING CIRCUIT; V. THE AcbSh FEEDING CIRCUIT AS A POTENTIAL SITE FOR PATHOLOGY AND THERAPEUTIC INTERVENTION IN THE TREATMENT OF EATING DISORDERS; References; CHAPTER 4: Hypothalamic Neuropeptides and Feeding Regulation; I. INTRODUCTION; II. NEUROPEPTIDE Y; III. THE OREXINS; IV. MELANIN-CONCENTRATING HORMONE; V. CONCLUSION; Acknowledgments; References; CHAPTER 5: Brainstem-Hypothalamic Neuropeptides and the Regulation of Feeding; I. THE CONTROL OF FEEDING 327 $aII. NEURAL INTEGRATION BY THE DORSAL VAGAL COMPLEXIII. CONSIDERATIONS IN ASSESSING THE ROLE OF "NEUROPEPTIDES"; IV. "HUMORAL" INTERACTIONS WITH THE DORSAL VAGAL COMPLEX; V. INTRINSIC PEPTIDERGIC NEURONS OF THE DORSAL VAGAL COMPLEX; VI. DESCENDING PEPTIDERGIC REGULATION OF BRAINSTEM FEEDING CIRCUITS; VII. SUMMARY AND POTENTIAL FOR DRUG DEVELOPMENT; References; CHAPTER 6: The Gut-Brain Axis in the Control of Eating; I. INTRODUCTION; II. GASTRIC MECHANORECEPTION; III. INTESTINAL CHOLECYSTOKININ (CCK); IV. AMYLIN; V. GHRELIN 327 $aVI. POTENTIALS AND PROBLEMS OF GUT-BRAIN AXIS SIGNALS IN THE TREATMENT OF OBESITYReferences; CHAPTER 7: Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite; I. INTRODUCTION AND OVERVIEW; II. MESOLIMBIC DOPAMINE CIRCUITRY AND ENERGY REGULATORY SIGNALS; III. BRAIN OPIOID SYSTEMS AND ENERGY REGULATORY SIGNALS; IV. ENDOCANNABINOIDS AND ENERGY REGULATORY SIGNALS; V. LHA CIRCUITRY AND ENERGY REGULATORY SIGNALS; VI. OTHER CNS SITES: TARGET FOR FUTURE STUDIES?; VII. HUMAN AND CLINICAL STUDIES: AT THE FOREFRONT OF OUR KNOWLEDGE; VIII. CONCLUDING REMARKS; Acknowledgments 327 $aReferencesCHAPTER 8: Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders; I. INTRODUCTION; II. POSSIBLE ROLES OF BRAIN REWARD SYSTEMS IN EATING DISORDERS; III. UNDERSTANDING BRAIN REWARD SYSTEMS FOR FOOD "LIKING" AND "WANTING"; IV. "WANTING" WITHOUT "LIKING"; V. A BRIEF HISTORY OF APPETITE: FOOD INCENTIVES, NOT HUNGER DRIVES; VI. CONNECTING BRAIN REWARD AND REGULATORY SYSTEMS; VII. CONCLUSION; Acknowledgments; References; CHAPTER 9: Pharmacology of Food, Taste, and Learned Flavor Preferences; I. INTRODUCTION; II. PHARMACOLOGY OF FOOD PREFERENCE 327 $aIII. PHARMACOLOGY OF UNLEARNED TASTE PREFERENCE AND REACTIVITY 330 $aThere is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single f 606 $aObesity$xPsychological aspects 606 $aAppetite 606 $aBody weight 608 $aElectronic books. 615 0$aObesity$xPsychological aspects. 615 0$aAppetite. 615 0$aBody weight. 676 $a616.39806 701 $aKirkham$b Tim C$0928503 701 $aCooper$b S. J$0928504 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458618103321 996 $aAppetite and body weight$92086848 997 $aUNINA