LEADER 05336nam 2200697Ia 450 001 9910458609303321 005 20200520144314.0 010 $a1-280-70765-8 010 $a9786610707652 010 $a0-08-046530-7 035 $a(CKB)1000000000364093 035 $a(EBL)281942 035 $a(OCoLC)162131389 035 $a(SSID)ssj0000305883 035 $a(PQKBManifestationID)11925012 035 $a(PQKBTitleCode)TC0000305883 035 $a(PQKBWorkID)10294256 035 $a(PQKB)10799426 035 $a(MiAaPQ)EBC281942 035 $a(Au-PeEL)EBL281942 035 $a(CaPaEBR)ebr10151380 035 $a(CaONFJC)MIL70765 035 $a(EXLCZ)991000000000364093 100 $a20060616d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 12$aA pharmacology primer$b[electronic resource] $etheory, applications, and methods /$fTerry Kenakin 205 $a2nd ed. 210 $aBurlington, MA ;$aLondon $cAcademic Press$dc2006 215 $a1 online resource (319 p.) 300 $aPrevious ed.: London: Elsevier, 2004. 311 $a0-08-057508-0 311 $a0-12-370599-1 320 $aIncludes bibliographical references and index. 327 $aFront cover; A PHARMACOLOGY PRIMER THEORY, APPLICATION, AND METHODS; Copyright page; Foreword to Second Edition; Foreword to First Edition; Table of contents; Chapter 1. What Is Pharmacology?; 1.1 About This Book; 1.2 What Is Pharmacology?; 1.3 The Receptor Concept; 1.4 Pharmacological Test Systems; 1.5 The Nature of Drug Receptors; 1.6 Pharmacological Intervention and the Therapeutic Landscape; 1.7 System-independent Drug Parameters: Affinity and Efficacy; 1.8 What Is Affinity?; 1.9 The Langmuir Adsorption Isotherm; 1.10 What Is Efficacy?; 1.11 Dose-response Curves 327 $a1.12 Chapter Summary and Conclusions1.13 Derivations: Conformational Selections as a Mechanism of Efficacy; References; Chapter 2. How Different Tissues Process Drug Response; 2.1 Drug Response as Seen Through the ''Cellular Veil''; 2.2 The Biochemical Nature of Stimulus-response Cascades; 2.3 The Mathematical Approximation of Stimulus-response Mechanisms; 2.4 System Effects on Agonist Response: Full and Partial Agonists; 2.5 Differential Cellular Response to Receptor Stimulus; 2.6 Receptor Desensitization and Tachyphylaxis; 2.7 The Measurement of Drug Activity 327 $a2.8 Advantages and Disadvantages of Different Assay Formats2.9 Drug Concentration as an Independent Variable; 2.10 Chapter Summary and Conclusions; 2.11 Derivations; References; Chapter 3. Drug-Receptor Theory; 3.1 About This Chapter; 3.2 Drug-Receptor Theory; 3.3 The Use of Mathematical Models in Pharmacology; 3.4 Some Specific Uses of Models in Pharmacology; 3.5 Classical Model of Receptor Function; 3.6 The Operational Model of Receptor Function; 3.7 Two-state Theory; 3.8 The Ternary Complex Model; 3.9 The Extended Ternary Model; 3.10 Constitutive Receptor Activity 327 $a3.11 The Cubic Ternary Complex Model3.12 Chapter Summary and Conclusions; 3.13 Derivations; References; Chapter 4. Pharmacological Assay Formats: Binding; 4.1 The Structure of This Chapter; 4.2 Binding Theory and Experiment; 4.3 Complex Binding Phenomena: Agonist Affinity from Binding Curves; 4.4 Experimental Prerequisites for Correct Application of Binding Techniques; 4.5 Chapter Summary and Conclusions; 4.6 Derivations; References; Chapter 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays; 5.1 Functional Pharmacological Experiments 327 $a5.2 The Choice of Functional Assays5.3 Recombinant Functional Systems; 5.4 Functional Experiments: Dissimulation in Time; 5.5 Experiments in Real Time Versus Stop Time; 5.6 The Measurement of Agonist Affinity in Functional Experiments; 5.7 Estimates of Relative Efficacy of Agonists in Functional Experiments; 5.8 Chapter Summary and Conclusions; 5.9 Derivations; References; Chapter 6. Orthosteric Drug Antagonism; 6.1 Introduction; 6.2 Kinetics of Drug-Receptor Interaction; 6.3 Surmountable Competitive Antagonism; 6.4 Noncompetitive Antagonism; 6.5 Agonist-Antagonist Hemi-equilibria 327 $a6.6 Resultant Analysis 330 $aThe Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.*Over 30 new figures and tables*More human interest information to provide readers with historical facts on pharmacology research*New section on therapeutics to help identify diseases and drug treatments*New section on new biological concepts relevant to pharmacological researc 606 $aPharmacology 606 $aDrugs 606 $aChemicals$xPhysiological effect 608 $aElectronic books. 615 0$aPharmacology. 615 0$aDrugs. 615 0$aChemicals$xPhysiological effect. 676 $a615.1 676 $a615/.7 700 $aKenakin$b Terrence P$0291558 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458609303321 996 $aA pharmacology primer$92086846 997 $aUNINA LEADER 02607nam 2200613Ia 450 001 9910451768403321 005 20200520144314.0 010 $a1-280-76582-8 010 $a9786610765829 010 $a0-8213-6891-5 035 $a(CKB)1000000000471583 035 $a(EBL)459513 035 $a(OCoLC)182530820 035 $a(SSID)ssj0000089885 035 $a(PQKBManifestationID)11990692 035 $a(PQKBTitleCode)TC0000089885 035 $a(PQKBWorkID)10092024 035 $a(PQKB)10520701 035 $a(MiAaPQ)EBC459513 035 $a(Au-PeEL)EBL459513 035 $a(CaPaEBR)ebr10167861 035 $a(CaONFJC)MIL76582 035 $a(EXLCZ)991000000000471583 100 $a20061107d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTools for institutional, political, and social analysis of policy reform$b[electronic resource] $ea sourcebook for development practitioners /$fJeremy Holland 210 $aWashington, DC $cWorld Bank$dc2007 215 $a1 online resource (292 p.) 300 $aDescription based upon print version of record. 311 $a0-8213-6890-7 320 $aIncludes bibliographical references and index. 327 $aContents; Foreword; Acknowledgments; Abbreviations; Part 1 Overview; Tables; Boxes; Figures; Part 2 Tools and Case Studies; Overview of Tools; Appendix A Contents of the Accompanying CD-Rom; Index 330 $aThe Sourcebook introduces a framework for social analysis in Poverty and Social Impact Analysis along with a set of practical tools that address the institutional, political, and social dimensions of policy design and implementation and how these impact poverty and distributional equity. It is designed for country practitioners working in policy analysis in a range of areas, including macroeconomic, sectoral, and public sector policy. 606 $aPoverty$xGovernment policy$zDeveloping countries$xEvaluation 606 $aEconomic assistance$xEvaluation 606 $aEconomic policy$xEvaluation 608 $aElectronic books. 615 0$aPoverty$xGovernment policy$xEvaluation. 615 0$aEconomic assistance$xEvaluation. 615 0$aEconomic policy$xEvaluation. 676 $a362.5/561091724 700 $aHolland$b Jeremy$f1966-$0696392 712 02$aWorld Bank. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451768403321 996 $aTools for institutional, political, and social analysis of policy reform$92471750 997 $aUNINA