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010   $a1-281-17949-3
010   $a9786611179496
010   $a3-540-75157-2
024 7 $a10.1007/978-3-540-75157-1
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035   $a(EBL)338204
035   $a(OCoLC)260242146
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035   $a(PQKBTitleCode)TC0000238802
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035   $a(DE-He213)978-3-540-75157-1
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100   $a20071211d2008      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aRNA interference$b[electronic resource] /$fPatrick J. Paddison, Peter K. Vogt, editors
205   $a1st ed. 2008.
210   $aBerlin $cSpringer$dc2008
215   $a1 online resource (282 p.)
225 1 $aCurrent topics in microbiology and immunology ;$v320
300   $aDescription based upon print version of record.
311   $a3-642-44445-8 
311   $a3-540-75156-4 
320   $aIncludes bibliographical references and index.
327   $aRNA Interference in Mammalian Cell Systems -- RNAi Pathway in C. elegans: The Argonautes and Collaborators -- Genetics and Biochemistry of RNAi in Drosophila -- Role of Dicer in Posttranscriptional RNA Silencing -- The Mechanism of RNase III Action: How Dicer Dices -- MicroRNA Metabolism in Plants -- Structure-Function Relationships Among RNA-Dependent RNA Polymerases -- RNAi-Mediated Chromatin Silencing in Fission Yeast -- A Role for RNAi in Heterochromatin Formation in Drosophila -- RNA-Mediated Transcriptional Gene Silencing in Human Cells -- RNA Silencing in Mammalian Oocytes and Early Embryos -- Identifying Human MicroRNAs.
330   $aIn the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
410  0$aCurrent topics in microbiology and immunology ;$v320.
606   $aGene silencing
606   $aRNA
608   $aElectronic books.
615  0$aGene silencing.
615  0$aRNA.
676   $a615.7924
701   $aVogt$b P. K$g(Peter K.),$f1932-$0934745
701   $aPaddison$b Patrick J$0934746
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910458389503321
996   $aRNA interference$92105041
997   $aUNINA