LEADER 05349nam 22006614a 450 001 9910458238203321 005 20200520144314.0 010 $a1-281-07062-9 010 $a9786611070625 010 $a0-12-289632-7 010 $a0-08-054118-6 035 $a(CKB)1000000000384343 035 $a(EBL)319073 035 $a(OCoLC)476114626 035 $a(SSID)ssj0000245831 035 $a(PQKBManifestationID)11234644 035 $a(PQKBTitleCode)TC0000245831 035 $a(PQKBWorkID)10179785 035 $a(PQKB)10456664 035 $a(MiAaPQ)EBC319073 035 $a(PPN)182573206 035 $a(Au-PeEL)EBL319073 035 $a(CaPaEBR)ebr10206109 035 $a(CaONFJC)MIL107062 035 $a(EXLCZ)991000000000384343 100 $a20011010d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSignal transduction$b[electronic resource] /$fBastien D. Gomperts, Peter E.R. Tatham, IJsbrand M. Kramer 210 $aSan Diego, Calif. $cAcademic Press$dc2002 215 $a1 online resource (441 p.) 300 $aDescription based upon print version of record. 311 $a0-12-289631-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Signal Transduction; Copyright Page; Contents; Preface; Chapter 1. Prologue: Signal transduction, origins and personalities; Transduction, the word and its meaning: one dictionary, different points of view; Hormones, evolution and history; Hormones: a definition; Neurotransmitters; Ergot; Receptors and ligands; Chapter 2. First messengers; Hormones; Binding of ligands to receptors; Chapter 3. Receptors; Adrenaline (again); a- and ß-adrenergic receptors; Acetylcholine receptors; Ion channel-linked receptors; The 7TM superfamily of G-protein linked receptors 327 $aReceptor-ligand interaction and receptor activationTransmitting signals into cells; Intracellular 7TM receptor domains and signal transmission; Adrenaline (yet again); Chapter 4. GTP-binding proteins and signal transduction; Nucleotides as metabolic regulators; GTP-binding proteins, G-proteins or GTPases; Ras proteins; Ras-GAPs; Essay: Activation of G-proteins without subunit dissociation; Chapter 5. Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C; Adenylyl cyclase; Phospholipase C; Chapter 6. The regulation of visual transduction 327 $aSensitivity of photoreceptorsPhotoreceptor mechanisms; Adaptation: calcium acts as a negative regulator; Photo-excitation of rhodopsin; Switching off the mechanism; A note on phototransduction in invertebrates; Chapter 7. Calcium and signal transduction; A new second messenger is discovered; Calcium and evolution; Distinguishing Ca2+ and Mg2+; Free, bound and trapped Ca2+; Cytosol Ca2+ is kept low; Detecting changes in cytosol Ca2+; Mechanisms that elevate cytosol Ca2+ concentration; The pattern of cytosol Ca2+ changes in single cells; Localization of intracellular second messengers 327 $aChapter 8. Calcium signallingCalcium binding by proteins; Effects of elevated calcium; Paradigms of calcium signalling; Chapter 9. Phosphorylation and dephosphorylation: Protein kinases A and C; Protein phosphorylation as a switch in cellular functioning; cAMP and the amplification of signals; Protein kinase A; Protein kinase A and the regulation of transcription; Protein kinase A and the activation of ERK; Actions of cAMP not mediated by PKA; Protein kinase C; The protein kinase C family; Structural domains and activation of protein kinase C 327 $aMultiple sources of DAG and other lipids to activate PKCDifferential localization of PKC isoforms; PKC anchoring proteins, STICKs, PICKs and RACKs; PKC and cell transformation; PKC and inflammation; Chapter 10. Growth factors: Setting the framework; Viruses and tumours; The discovery of NGF... and EGF; Platelet derived growth factor; Transforming growth factors; Problems with nomenclature; Essay: The cell cycle; Essay: Cancer and cell transformation; Chapter 11. Signalling pathways operated by receptor protein tyrosine kinases; The tyrosine kinase family; Tyrosine kinase-containing receptors 327 $aBranching of the signalling pathway 330 $aSignal Transduction is a well-illustrated, coherent look at cellular signaling processes. Beginning with the basics, it explains how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and then shows how these inputs are integrated and coordinated. The extensive color artwork provides the reader with a clearer comprehension of key topics, and margin notes are incorporated to highlight milestones in the evolution of signal transduction. This book serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scien 606 $aCellular signal transduction 608 $aElectronic books. 615 0$aCellular signal transduction. 676 $a571.6 700 $aGomperts$b B. D$01056431 701 $aTatham$b Peter E. 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