LEADER 03888nam 2200793 a 450 001 9910458136603321 005 20200520144314.0 010 $a0-262-31181-X 010 $a0-262-28313-1 010 $a0-585-06933-6 010 $a1-282-09689-3 010 $a9786612096891 035 $a(CKB)1000000000380358 035 $a(OCoLC)614511479 035 $a(CaPaEBR)ebrary10015360 035 $a(SSID)ssj0000139005 035 $a(PQKBManifestationID)11139568 035 $a(PQKBTitleCode)TC0000139005 035 $a(PQKBWorkID)10107995 035 $a(PQKB)10875550 035 $a(SSID)ssj0001141127 035 $a(PQKBManifestationID)12499778 035 $a(PQKBTitleCode)TC0001141127 035 $a(PQKBWorkID)11089758 035 $a(PQKB)11647233 035 $a(MiAaPQ)EBC3338461 035 $a(OCoLC)42922453$z(OCoLC)47905737$z(OCoLC)232161196$z(OCoLC)243510868$z(OCoLC)243510869$z(OCoLC)318204935$z(OCoLC)488706724$z(OCoLC)532461718$z(OCoLC)614511479$z(OCoLC)646708926$z(OCoLC)649223347$z(OCoLC)939263614 035 $a(OCoLC-P)42922453 035 $a(MaCbMITP)2415 035 $a(Au-PeEL)EBL3338461 035 $a(CaPaEBR)ebr10015360 035 $a(OCoLC)939263614 035 $a(EXLCZ)991000000000380358 100 $a19980827d1999 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDigital capitalism$b[electronic resource] $enetworking the global market system /$fDan Schiller 210 $aCambridge, Mass. $cMIT Press$dc1999 215 $a1 online resource (314 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-262-19417-1 311 $a0-262-69233-3 320 $aIncludes bibliographical references and index. 330 $aSchiller traces the transformation of the Internet from government, military, and educational tool to agent of "digital capitalism" through three critically important and interlinked realms.The networks that comprise cyberspace were originally created at the behest of government agencies, military contractors, and allied educational institutions. Over the past generation or so, however, a growing number of these networks began to serve primarily corporate users. Under the sway of an expansionary market logic, the Internet began a political-economic transition toward what Dan Schiller calls "digital capitalism."Schiller traces these metamorphoses through three critically important and interlinked realms. Parts I and II deal with the overwhelmingly "neoliberal" or market-driven policies that influence and govern the telecommunications system and their empowerment of transnational corporations while at the same time exacerbating exisiting social inequalities. Part III shows how cyberspace offers uniquely supple instruments with which to cultivate and deepen consumerism on a transnational scale, especially among privileged groups. Finally, Part IV shows how digital capitalism has already overtaken education, placing it at the mercy of a proprietary market logic. 606 $aInformation society 606 $aElectronic commerce$xSocial aspects 606 $aInternational economic integration 606 $aInformation superhighway 606 $aInternet$xSocial aspects 606 $aTelecommunication$xHistory 608 $aElectronic books. 615 0$aInformation society. 615 0$aElectronic commerce$xSocial aspects. 615 0$aInternational economic integration. 615 0$aInformation superhighway. 615 0$aInternet$xSocial aspects. 615 0$aTelecommunication$xHistory. 676 $a303.48/33 700 $aSchiller$b Dan$f1951-$0150286 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458136603321 996 $aDigital capitalism$952442 997 $aUNINA LEADER 01468nam 2200457 450 001 9910808537403321 005 20200520144314.0 010 $a1-945459-12-3 035 $a(CKB)4100000006669551 035 $a(MiAaPQ)EBC5508400 035 $a(Au-PeEL)EBL5508400 035 $a(OCoLC)1019854415 035 $a(EXLCZ)994100000006669551 100 $a20180927d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAssessing service-learning and civic engagement $eprinciples and techniques /$fSherril B. Gelmon [and four others] 205 $aSecond edition. 210 1$aBoston, Massachusettts :$cCampus Compact,$d[2018] 210 4$d2018 215 $a1 online resource (170 pages) 300 $a"Distributed by Stylus Publishing." 320 $aIncludes bibliographical references and index. 606 $aService learning$zUnited States 606 $aCommunity and college$zUnited States 606 $aPolitical participation$zUnited States 615 0$aService learning 615 0$aCommunity and college 615 0$aPolitical participation 676 $a361.3/70973 700 $aGelmon$b Sherril B.$f1955-$01687448 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910808537403321 996 $aAssessing service-learning and civic engagement$94060903 997 $aUNINA LEADER 05363nam 2200649Ia 450 001 9910829904503321 005 20170816122630.0 010 $a1-280-72281-9 010 $a9786610722815 010 $a3-527-60876-1 010 $a3-527-60860-5 035 $a(CKB)1000000000376655 035 $a(EBL)481418 035 $a(SSID)ssj0000157791 035 $a(PQKBManifestationID)11149262 035 $a(PQKBTitleCode)TC0000157791 035 $a(PQKBWorkID)10139905 035 $a(PQKB)10093951 035 $a(MiAaPQ)EBC481418 035 $a(OCoLC)85821120 035 $a(EXLCZ)991000000000376655 100 $a20060111d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFragment-based approaches in drug discovery$b[electronic resource] /$fedited by Wolfgang Jahnke and Daniel A. Erlanson 210 $aWeinheim $cWiley-VCH ;$a[Chichester $cJohn Wiley, distributor]$dc2006 215 $a1 online resource (393 p.) 225 1 $aMethods and principles in medicinal chemistry ;$v34 300 $aDescription based upon print version of record. 311 $a3-527-31291-9 320 $aIncludes bibliographical references and index. 327 $aFragment-based Approaches in Drug Discovery; Contents; Preface; A Personal Foreword; List of Contributors; Part I: Concept and Theory; 1 The Concept of Fragment-based Drug Discovery; 1.1 Introduction; 1.2 Starting Small: Key Features of Fragment-based Ligand Design; 1.2.1 FBS Samples Higher Chemical Diversity; 1.2.2 FBS Leads to Higher Hit Rates; 1.2.3 FBS Leads to Higher Ligand Efficiency; 1.3 Historical Development; 1.4 Scope and Overview of this Book; References; 2 Multivalency in Ligand Design; 2.1 Introduction and Overview; 2.2 Definitions of Terms 327 $a2.3 Selection of Key Experimental Studies2.3.1 Trivalency in a Structurally Simple System; 2.3.2 Cooperativity (and the Role of Enthalpy) in the "Chelate Effect"; 2.3.3 Oligovalency in the Design of Inhibitors to Toxins; 2.3.4 Bivalency at Well Defined Surfaces (Self-assembled Monolayers, SAMs); 2.3.5 Polyvalency at Surfaces of Viruses, Bacteria, and SAMs; 2.4 Theoretical Considerations in Multivalency; 2.4.1 Survey of Thermodynamics; 2.4.2 Additivity and Multivalency; 2.4.3 Avidity and Effective Concentration (C(eff)); 2.4.4 Cooperativity is Distinct from Multivalency 327 $a2.4.5 Conformational Entropy of the Linker between Ligands2.4.6 Enthalpy/Entropy Compensation Reduces the Benefit of Multivalency; 2.5 Representative Experimental Studies; 2.5.1 Experimental Techniques Used to Examine Multivalent Systems; 2.5.1.1 Isothermal Titration Calorimetry; 2.5.1.2 Surface Plasmon Resonance Spectroscopy; 2.5.1.3 Surface Assays Using Purified Components (Cell-free Assays); 2.5.1.4 Cell-based Surface Assays; 2.5.2 Examination of Experimental Studies in the Context of Theory; 2.5.2.1 Trivalency in Structurally Simple Systems 327 $a2.5.2.2 Cooperativity (and the Role of Enthalpy) in the "Chelate Effect"2.5.2.3 Oligovalency in the Design of Inhibitors of Toxins; 2.5.2.4 Bivalency in Solution and at Well Defined Surfaces (SAMs); 2.5.2.5 Polyvalency at Surfaces (Viruses, Bacteria, and SAMs); 2.6 Design Rules for Multivalent Ligands; 2.6.1 When Will Multivalency Be a Successful Strategy to Design Tight-binding Ligands?; 2.6.2 Choice of Scaffold for Multivalent Ligands; 2.6.2.1 Scaffolds for Oligovalent Ligands; 2.6.2.2 Scaffolds for Polyvalent Ligands; 2.6.3 Choice of Linker for Multivalent Ligands 327 $a2.6.3.1 Rigid Linkers Represent a Simple Approach to Optimize Affinity2.6.3.2 Flexible Linkers Represent an Alternative Approach to Rigid Linkers to Optimize Affinity; 2.6.4 Strategy for the Synthesis of Multivalent Ligands; 2.6.4.1 Polyvalent Ligands: Polymerization of Ligand Monomers; 2.6.4.2 Polyvalent Ligands: Functionalization with Ligands after Polymerization; 2.7 Extensions of Multivalency to Lead Discovery; 2.7.1 Hetero-oligovalency Is a Broadly Applicable Concept in Ligand Design; 2.7.2 Dendrimers Present Opportunities for Multivalent Presentation of Ligands 327 $a2.7.3 Bivalency in the Immune System 330 $aThis first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies. 410 0$aMethods and principles in medicinal chemistry ;$vv. 34. 606 $aDrug development 606 $aLigands (Biochemistry) 615 0$aDrug development. 615 0$aLigands (Biochemistry) 676 $a615 676 $a615.1901 701 $aJahnke$b Wolfgang$01707025 701 $aErlanson$b Daniel A$01707026 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829904503321 996 $aFragment-based approaches in drug discovery$94094909 997 $aUNINA