LEADER 05479nam 2200685Ia 450 001 9910458126103321 005 20200520144314.0 010 $a1-281-03721-4 010 $a9786611037215 010 $a0-08-054594-7 035 $a(CKB)1000000000364013 035 $a(EBL)299465 035 $a(OCoLC)271426948 035 $a(SSID)ssj0000112063 035 $a(PQKBManifestationID)11142568 035 $a(PQKBTitleCode)TC0000112063 035 $a(PQKBWorkID)10085632 035 $a(PQKB)10833929 035 $a(MiAaPQ)EBC299465 035 $a(Au-PeEL)EBL299465 035 $a(CaPaEBR)ebr10186834 035 $a(CaONFJC)MIL103721 035 $a(EXLCZ)991000000000364013 100 $a20070202d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe biology of human longevity$b[electronic resource] $einflammation, nutrition, and aging in the evolution of lifespans /$fCaleb E. Finch 210 $aAmsterdam ;$aBoston $cAcademic Press$dc2007 215 $a1 online resource (640 p.) 300 $aDescription based upon print version of record. 311 $a0-12-373657-9 320 $aIncludes bibliographical references(p. 417-599) and indexes. 327 $aFront Cover; The Biology of Human Longevity; Copyright Page; Contents; Preface; Acknowledgments; Chapter 1: Inflammation and Oxidation in Aging and Chronic Diseases; Part I; 1.1. Overview; 1.2. Experimental Models for Aging; 1.2.1. Mortality Rate Accelerations; 1.2.2. Mammals; 1.2.3. Cultured Cell Models and Replicative Senescence; 1.2.4. Invertebrate Models; 1.2.5. Yeast; 1.2.6. The Biochemistry of Aging; 1.2.7. Biomarkers of Aging and Mortality Risk Markers; 1.2.8. Evolutionary Theories of Aging; 1.3. Outline of Inflammation; 1.3.1. Innate Defense Mechanisms 327 $a1.3.2. Genetic Variations of Inflammatory Responses1.3.3. Inflammation and Energy; 1.3.4. Amyloids and Inflammation; 1.4. Bystander Damage and Dependent Variables in Senescence; 1.4.1. Free Radical Bystander Damage (Type 1); 1.4.2. Glyco-oxidation (Type 2); 1.4.3. Chronic Proliferation (Type 3); 1.4.4. Mechanical Bystander Effects (Type 4); Part II; 1.5. Arterial Aging and Atherosclerosis; 1.5.1. Overview and Ontogeny; 1.5.2. Hazards of Hypertension; 1.5.3. Mechanisms; 1.5.3.1. Inflammation; 1.5.3.2. Hemodynamics; 1.5.3.3. Aging; 1.5.3.4. Endothelial Progenitor Cells 327 $a1.5.4. Blood Risk Factors for Vascular Disease and Overlap with Acute Phase Responses1.6. Alzheimer Disease and Vascular-related Dementias; 1.6.1. Neuropathology of Alzheimer Disease; 1.6.2. Inflammation in Alzheimer Disease; 1.6.3. Prodromal Stages of Alzheimer Disease; 1.6.4. Overlap of Alzheimer and Cerebrovascular Changes; 1.6.5. Insulin and IGF-1 in Vascular Disease and Alzheimer Disease; 1.6.6. Blood Inflammatory Proteins: Markers for Disease or Aging, or Both?; 1.7. Inflammation in Obesity; 1.8. Processes of Normal Aging in the Absence of Specific Diseases; 1.8.1. Brain 327 $a1.8.2. Generalized Inflammatory Changes in Normal Tissue Aging1.9. Summary; Chapter 2 :Infections, Inflammogens, and Drugs; 2.1. Introduction; 2.2. Vascular Disease; 2.2.1. Historical Associations of Infections and Vascular Mortality; 2.2.2. Modern Serologic Associations; 2.3. Infections from the Central Tube: Metchnikoff Revisited; 2.3.1. Humans: Leakage from Periodontal Disease and Possibly the Lower Intestine; 2.3.2. Worms and Flies as Models for Human Intestinal Microbial Intrusion; 2.4. Aerosols and Dietary Inflammogens; 2.4.1. Aerosols; 2.4.2. Food 327 $a2.5. Infections, Inflammation, and Life Span2.5.1. Historical Human Populations; 2.5.2. Longer Rodent Life Spans with Improved Husbandry; 2.6. Are Infections a Cause of Obesity?; 2.7. Inflammation, Dementia, and Cognitive Decline; 2.7.1. Alzheimer Disease; 2.7.2. HIV, Dementia, and Amyloid; 2.7.3. Peripheral Amyloids; 2.7.4. Inflammation and Cognitive Decline During 'Usual' Aging; 2.8. Immunosenescence and Stem Cells; 2.8.1. Immunosenescence and Cumulative Exposure; 2.8.2. Immunosenescence and Telomere Loss; 2.8.3. Inflammation and Stem Cells; 2.9. Cancer, Infection, and Inflammation 327 $a2.9.1. Helicobacter Pylori and Hepatitis B Virus 330 $aWritten by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan a 606 $aLongevity$xPhysiological aspects 606 $aAging$xPhysiological aspects 606 $aInflammation 606 $aNutrition 608 $aElectronic books. 615 0$aLongevity$xPhysiological aspects. 615 0$aAging$xPhysiological aspects. 615 0$aInflammation. 615 0$aNutrition. 676 $a612.6/8 700 $aFinch$b Caleb Ellicott$0866265 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910458126103321 996 $aThe biology of human longevity$91933323 997 $aUNINA