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-- The collective turn: cooperative groups as epistemic organizations -- Assembling the US cooperative system -- Screening for drugs: from mice to humans -- Tinkering with the cooperative group structure -- Meanwhile in Europe -- Clinical trial statistics -- What is a random sample? -- What is statistical significance? -- Statisticians, statistics, and early cooperative clinical trials -- Statisticians at the NIH -- Statisticians in Paris -- Fabricating the tools of the trade -- Controversial methods -- The emergence of the phase system -- Criticism and the redefinition of clinical cancer trials as an autonomous form of research -- Clinical cancer research under fire -- The reorganization of screening and clinical trials in the United States -- Surgery and radiotherapy in the cooperative groups -- An avalanche of numbers from the new style of practice (1965-89) -- A web of trials -- Breast cancer and its trials -- The lessons of the breast cancer trials -- The emergence of combination chemotherapy -- The multiple meanings of breast cancer trials -- Statisticians, data centers, and the organization of large-scale clinical trials -- Centers of calculation: us statisticians and the data center -- The mechanics of data production -- Meanwhile in Europe, take two -- Back in the USA: group statisticians and NCI statisticians -- Insiders' dissent: the randomization debate -- A relational space of substances and regimens -- The clinical evaluation of substances -- Screening substances: the animal screen -- Procuring compounds -- Oncopolitics? reshaping collaborative research -- Centralization or coordination? the European debate -- Clinical trials as clinical research: the US debate -- Oncology in the community -- Targeted therapy, targeted trials (1990-2006) -- Second interlude: molecular biology and oncogenes -- The rise of molecular biology -- Cancer and molecular biology: 1960-80 -- The clinical isolation of human oncogenes -- Oncogenes and oncoproteins since 1982 -- Magic bullets? the Gleevec trials -- Molecular biology and targeted substances -- The trials of a targeted therapy -- Where did Gleevec come from? -- Monitoring data, managing risks -- A medical oncologist and his patients -- Patients and activists -- Targeted therapy and clinical cancer research -- Introduction: molecular biology and translational research -- Molecular biology and the US cooperative groups -- The reorganization of the drug discovery process and the transformation of the NCI screen -- Clinical trials in a targeted age -- More oncopolitics -- Looking back and looking forward -- The observational alternative to clinical cancer trials -- Comparative effectiveness and clinical trials. 330 $aUntil the early 1960's, cancer treatment consisted primarily of surgery and radiation therapy. Most practitioners then viewed the treatment of terminally ill cancer patients with heroic courses of chemotherapy as highly questionable. The randomized clinical trials that today sustain modern oncology were relatively rare and prompted stiff opposition from physicians, who were loath to assign patients randomly to competing treatments. Yet today these trials form the basis of medical oncology. How did such a spectacular change occur? How did medical oncology pivot from a nonentity and, in some regards, a reviled practice to the central position it now occupies in modern medicine? In Cancer on Trial Peter Keating and Alberto Cambrosio explore how practitioners established a new style of practice, at the center of which lies the cancer clinical trial. Far from mere testing devices, these trials have become full-fledged experiments that have redefined the practices of clinicians, statisticians, and biologists. Keating and Cambrosio investigate these trials and how they have changed since the 1960's, all the while demonstrating their significant impact on the progression of oncology. A novel look at the institution of clinical cancer research and therapy, this book will be warmly welcomed by historians, sociologists, and anthropologists of science and medicine, as well as clinicians and researchers in the cancer field. 606 $aOncology$xResearch 606 $aCancer$xResearch 608 $aElectronic books. 615 0$aOncology$xResearch. 615 0$aCancer$xResearch. 676 $a616.99/40072 700 $aKeating$b Peter$f1953-$0967186 701 $aCambrosio$b Alberto$f1950-$0967187 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457715103321 996 $aCancer on trial$92195681 997 $aUNINA LEADER 04005nam 22006615 450 001 9910300235403321 005 20250708144735.0 010 $a94-017-9576-2 024 7 $a10.1007/978-94-017-9576-0 035 $a(CKB)3710000000291726 035 $a(EBL)1966752 035 $a(OCoLC)908086133 035 $a(SSID)ssj0001386640 035 $a(PQKBManifestationID)11884099 035 $a(PQKBTitleCode)TC0001386640 035 $a(PQKBWorkID)11374538 035 $a(PQKB)10440185 035 $a(DE-He213)978-94-017-9576-0 035 $a(MiAaPQ)EBC1966752 035 $a(PPN)183089898 035 $a(EXLCZ)993710000000291726 100 $a20141119d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNeurosurgical Treatments for Psychiatric Disorders /$fedited by Bomin Sun, Antonio De Salles 205 $a1st ed. 2015. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015. 215 $a1 online resource (229 p.) 300 $aDescription based upon print version of record. 311 08$a94-017-9575-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aRelated circuitry and synaptic connectivity in psychiatric disorders -- Neuroimaging in psychiatric disorders -- Neuroimaging in psychiatry -- DBS in psychiatry and the pendulum of history -- Ablative surgery for neuropsychiatric disorders: past, present, future -- Legal issues in behavioral surgery -- Preoperative evaluation and postoperative follow-up of deep brain stimulation for psychiatric disorders -- Ablative surgery for depression -- Deep Brain Stimulation for the Management of Treatment-refractory Major Depressive Disorder -- Ablative surgery for obsessive-compulsive disorders -- DBS for Obsessive-Compulsive Disorder -- Focused Ultrasound for the treatment of Obsessive-Compulsive Disorder -- Deep Brain Stimulation for Tourette Syndrome -- Stereotactic neurosurgery for Drug Addiction -- Surgical Treatments for Anorexia Nervosa -- Neurosurgery for the Treatment of Refractory Schizophrenia -- Surgical management for aggressive behavior -- Deep Brain Stimulation in Aggressive Behavior -- Radiosurgery for psychiatric disorders. 330 $aThis book describes contemporary clinical practice in the application of neurosurgical methods to the treatment of psychiatric disorders. It covers diverse topics such as neuroimaging, ethics and a historical review, Gamma Knife and High Frequency Ultrasound ablation, deep brain electrical stimulation and preoperative evaluation and postoperative follow-up. Its application in Obsessive Compulsive Disorder, Major Depression, Tourette syndrome, Addiction, Anorexia, Aggression and Schizophrenia are discussed in separated chapters. This book presents concise information provided by clinical and academic practitioners and will facilitate the application of neurosurgical treatment techniques to patients. Editor Bomin Sun is an Associate Professor of Neurosurgery at the Center for Functional Neurosurgery, Ruijin Hospital, Shanghai, China. Editor Antonio De Salles is Professor at the Department of Neurosurgery, University of California, Los Angeles, CA, USA. 606 $aNervous system$xSurgery 606 $aPsychiatry 606 $aNeurology 606 $aNeurosurgery 606 $aPsychiatry 606 $aNeurology 615 0$aNervous system$xSurgery. 615 0$aPsychiatry. 615 0$aNeurology. 615 14$aNeurosurgery. 615 24$aPsychiatry. 615 24$aNeurology. 676 $a610 676 $a616.8 676 $a616.89 676 $a617.48 702 $aSun$b Bomin$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aSalles$b Antonio De$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300235403321 996 $aNeurosurgical Treatments for Psychiatric Disorders$91866846 997 $aUNINA