LEADER 05405nam 2200709Ia 450 001 9910457277303321 005 20200520144314.0 010 $a1-281-00380-8 010 $a9786611003807 010 $a0-08-047527-2 024 3 $z9780444520852 035 $a(CKB)1000000000357883 035 $a(EBL)291684 035 $a(OCoLC)162587033 035 $a(SSID)ssj0000254977 035 $a(PQKBManifestationID)11208350 035 $a(PQKBTitleCode)TC0000254977 035 $a(PQKBWorkID)10211175 035 $a(PQKB)11016301 035 $a(MiAaPQ)EBC291684 035 $a(PPN)182565491 035 $a(Au-PeEL)EBL291684 035 $a(CaPaEBR)ebr10172809 035 $a(CaONFJC)MIL100380 035 $a(EXLCZ)991000000000357883 100 $a20070605d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSystems biology$b[electronic resource] $ephilosophical foundations /$fedited by Fred C. Boogerd ... [et al.] 205 $a1st ed. 210 $aAmsterdam ;$aBoston $cElsevier$d2007 215 $a1 online resource (361 p.) 300 $aDescription based upon print version of record. 311 $a0-444-52085-6 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Systems Biology; Copyright Page; Table of Contents; List of Contributors; Contributor Biographies; Preface; SECTION I Introduction; Chapter 1 Towards philosophical foundations of Systems Biology: introduction; 1. SYSTEMS BIOLOGY: A NEW SCIENCE IN SEARCH OF METHODOLOGIES AND PHILOSOPHICAL FOUNDATIONS; 2. SYSTEMS BIOLOGY; 2.1. History of systems biology; 2.2. What is contemporary systems biology?; 2.3. Approaches to systems biology; 3. TOWARDS A PHILOSOPHY OF SYSTEMS BIOLOGY; 3.1. The philosophy of molecular biology itself needs no further elaboration 327 $a3.2. Philosophers focus on philosophy of evolutionary biology3.3. A philosophy of systems biology is lacking but needed; 4. INTRODUCTION OF A NUMBER OF PHILOSOPHICAL ASPECTS OF SYSTEMS BIOLOGY; 4.1. Two types of reductionism; 4.2. A continuum of reductionism to antireductionism; 4.3. Types of explanation; 4.4. Mechanistic explanation; 4.5. Systems biology and models; 4.6. What is life?; 5. AIM AND OVERVIEW OF THE BOOK; REFERENCES; SECTION II Research programs of Systems Biology; Chapter 2 The methodologies of systems biology; SUMMARY 327 $a1. THE METHODOLOGY AND PHILOSOPHICAL FOUNDATIONS OF THE VARIOUS SCIENCES1.1. Physics; 1.2. Biology; 1.3. Biochemistry and molecular biology; 1.4. Cell Biology: The living cell; 2. LIMITATIONS TO THE SCIENTIFIC STATUS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY; 2.1. Inaccuracy; 2.2. Inability to deal with emergence; 2.3. Frustrated aspiration of biochemistry and molecular biology to . . . biology; 2.4. Irreducibility; 2.5. Lack of testability because of undefinedness; 2.6. Lack of experimental accessibility; 2.7. Lack of analysability; 3. RISING ABOVE THE LIMITATIONS; 3.1. Genomics 327 $a3.2. Soon everything will be known . . . : Will biology become physics, at last?3.3. Observing or understanding?; 3.4. Systems biology; 4. TOWARDS A SYSTEMATIC METHODOLOGY OF SYSTEMS BIOLOGY; 4.1. The goals of systems biology; 4.2. Systems biology: What it is; 4.3. The spiral of knowledge; 4.4. The special role of mathematics in systems biology: Calculating emergence; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3 Methodology is Philosophy; SUMMARY; 1. INTRODUCTION; 2. FROM MOLECULES TO DIABETES VIA METABOLISM AND SYSTEMIC PHYSIOLOGY; 3. MRS AND MCA FORM A SUCCESSFUL METHODOLOGY FOR SYSTEMS BIOLOGY 327 $a4. CONCLUSIONREFERENCES; Chapter 4 How can we understand metabolism?; SUMMARY; 1. INTRODUCTION; 2. TRADITIONAL PRINCIPLES OF METABOLISM; 3. THE RISE OF SYSTEMS ANALYSIS OF METABOLISM; 4. SHOULD WE EXPECT METABOLISM TO BE UNDERSTANDABLE?; 5. IS SIMULATING CELL METABOLISM THE SAME AS UNDERSTANDING IT?; REFERENCES; Chapter 5 On building reliable pictures with unreliable data: An evolutionary and developmental coda for the new systems biology?; SUMMARY; 1. INTRODUCTION; 2. THE NEW SYSTEMS BIOLOGY AND EVO-DEVO; 3. THE PROBLEM OF DATA RELIABILITY IN THE ANALYSIS OF LARGE SYSTEMS 327 $a4. DATA ERRORS AND MOLAR SYSTEM PROPERTIES 330 $aSystems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies.* Answers the question of what distinguishes the living from the non-living* An in-dept 606 $aBiology$xPhilosophy 606 $aBiological systems 606 $aBiological models 608 $aElectronic books. 615 0$aBiology$xPhilosophy. 615 0$aBiological systems. 615 0$aBiological models. 676 $a570.11 676 $a571 701 $aBoogerd$b Fred C$0972384 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457277303321 996 $aSystems biology$92211109 997 $aUNINA