LEADER 05399nam 22006733a 450 001 9910457266403321 005 20200520144314.0 010 $a1-280-72919-8 010 $a9786610729197 010 $a0-08-046669-9 035 $a(CKB)1000000000357911 035 $a(EBL)282083 035 $a(OCoLC)437175612 035 $a(SSID)ssj0000308252 035 $a(PQKBManifestationID)11260623 035 $a(PQKBTitleCode)TC0000308252 035 $a(PQKBWorkID)10270419 035 $a(PQKB)10659974 035 $a(MiAaPQ)EBC282083 035 $a(Au-PeEL)EBL282083 035 $a(CaPaEBR)ebr10155889 035 $a(CaONFJC)MIL72919 035 $a(OCoLC)935262642 035 $a(EXLCZ)991000000000357911 100 $a20061122d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRespiratory syncytial virus$b[electronic resource] /$feditor, Patricia Cane 210 $aAmsterdam ;$aLondon $cElsevier$d2006 215 $a1 online resource (349 p.) 225 1 $aPerspectives in medical virology,$x0168-7069 ;$vv. 14 300 $aDescription based upon print version of record. 311 $a0-444-52030-9 320 $aIncludes bibliographical references and index. 327 $aCover; Respiratory Syncytial Virus; Copyright Page; Contents; Preface; Molecular Biology of Human Respiratory Syncytial Virus; Introduction; The virion; The infectious cycle; Experimental systems to study the replicative cycle of HRSV; Virus entry; Transcription and replication of the viral genome; Virus assembly; Virus-host cell interactions; Acknowledgements; References; Immunology of RSV; The innate immune response; The adaptive immune response; Conclusions; References; Molecular Epidemiology and Evolution of RSV; Introduction; RSV groups and genotypes; Structure of epidemics 327 $aGeographic distribution of RSV strainsThe G protein; Evolution of RSV; Emergence of new lineages; Disappearance of lineages; Mechanism of selection of new strains; Paradox; Reinfection with RSV; Conclusions; References; Genetic Susceptibility to RSV Disease; Epidemiological evidence of genetic susceptibility to RSV infection in infancy; Evidence that the host response rather than the virus is responsible for disease; Requirements for effective genetic association studies; Genetic association studies of RSV bronchiolitis; Other studies; General comments; The future; References 327 $aPathogenesis of RSV in ChildrenIntroduction; Viral infection and cytotoxicity; The immune response to infection; Conclusion; References; RSV Infection in Elderly Adults; Introduction; Epidemiology; Clinical manifestations and complications of RSV infection in elderly adults; Diagnosis of RSV infection; Treatment of RSV infection; Prevention of RSV infection; Conclusions; References; Respiratory Syncytial Virus Disease Burden in the Developing World; Introduction; Methods, definitions, limitations; Denominator-based data on incidence; Associated mortality 327 $aDisease-causing agent or benign co-infectionRisk factors for RSV infection; Additional burdens of disease; Temporal dynamics of RSV: Where and how does it persist; Conclusions and future research needs; Abbreviations; References; Vaccines against Human Respiratory Syncytial Virus; Introduction: the burden of disease and the need for a vaccine; Considerations in developing an RSV vaccine; Formalin-inactivated RSV (FI-RSV); Subunit vaccines; Live-attenuated RSV strains; Live-vectored RSV vaccines; DNA vaccines; Perspective; Acknowledgment; References 327 $aDevelopment of Antivirals against Respiratory Syncytial VirusIntroduction; Slow progress; Vaccines versus antivirals; Brief history of RSV antiviral development; Modern approaches to antiviral discovery; Models of RSV disease; Alternative model of human RSV in tissue culture; Clinical trials of RSV agents; Drugs in development; Miscellaneous (unknown) mechanisms; Inhibiting host cell functions; Antisense compounds and siRNA; Future prospects; Acknowledgements; References; Pneumonia Virus of Mice; The natural history of PVM; Characteristics of the PVM virion; The molecular biology of PVM 327 $aPVM proteins 330 $aRespiratory syncytial virus (RSV) was first identified half a century ago in 1956. Following its discovery, the virus soon became recognised as a major viral pathogen causing extensive outbreaks of respiratory tract infections in both the very young and in vulnerable adults. It is an unusual virus in that it can cause repeated reinfections throughout life. The topics covered within this volume are wide ranging in scope from the most basic molecular biology of the virus to the clinical picture of RSV in the developing world. The internationally recognised experts were invited not only to revi 410 0$aPerspectives in medical virology ;$vv. 14. 606 $aRespiratory organs$xDiseases 606 $aRespiratory syncytial virus 608 $aElectronic books. 615 0$aRespiratory organs$xDiseases. 615 0$aRespiratory syncytial virus. 676 $a616.20019 701 $aCane$b Patricia$0956101 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457266403321 996 $aRespiratory syncytial virus$92164303 997 $aUNINA