LEADER 05211nam 2200673Ia 450 001 9910457240503321 005 20200520144314.0 010 $a1-282-49085-0 010 $a9786612490859 010 $a0-470-56752-X 010 $a0-470-56751-1 035 $a(CKB)2550000000007147 035 $a(EBL)484847 035 $a(OCoLC)593240074 035 $a(SSID)ssj0000343675 035 $a(PQKBManifestationID)11947805 035 $a(PQKBTitleCode)TC0000343675 035 $a(PQKBWorkID)10290890 035 $a(PQKB)11519486 035 $a(MiAaPQ)EBC484847 035 $a(Au-PeEL)EBL484847 035 $a(CaPaEBR)ebr10361175 035 $a(CaONFJC)MIL249085 035 $a(EXLCZ)992550000000007147 100 $a20090519d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aThermodynamics of pharmaceutical systems$b[electronic resource] $ean introduction to theory and applications /$fKenneth A. Connors, Sandro Mecozzi 205 $a2nd ed. 210 $aHoboken, NJ $cJohn Wiley & Sons$dc2010 215 $a1 online resource (379 p.) 300 $aDescription based upon print version of record. 311 $a0-470-42512-1 320 $aIncludes bibliographical references and index. 327 $aTHERMODYNAMICS OF PHARMACEUTICAL SYSTEMS; CONTENTS; PREFACE; PREFACE TO THE FIRST EDITION; 0. Review of Mathematics; 0.1. Introduction; 0.2. Dimensions and Units; 0.3. Logarithms and Exponents; 0.4. Algebraic and Graphical Analysis; 0.5. Dealing with Change; 0.6. Statistical Treatment of Data; Problems; I BASIC THERMODYNAMICS; 1. Energy and the First Law of Thermodynamics; 1.1. Fundamental Concepts; 1.2. The First Law of Thermodynamics; 1.3. The Enthalpy; Problems; 2. The Entropy Concept; 2.1. The Entropy Defined; 2.2. The Second Law of Thermodynamics; 2.3. Applications of the Entropy Concept 327 $aProblems3. The Free Energy; 3.1. Properties of the Free Energy; 3.2. The Chemical Potential; Problems; 4. Equilibrium; 4.1. Conditions for Equilibrium; 4.2. Physical Processes; 4.3. Chemical Equilibrium; Problems; II THERMODYNAMICS OF PHYSICAL PROCESSES; 5. Introduction to Physical Processes; 5.1. Scope; 5.2. Concentration Scales; 5.3. Standard States; Problems; 6. Phase Transformations; 6.1. Pure Substances; 6.2. Multicomponent Systems; Problems; 7. Solutions of Nonelectrolytes; 7.1. Ideal Solutions; 7.2. Nonideal Solutions; 7.3. Partitioning Between Liquid Phases; Problems 327 $a8. Solutions of Electrolytes8.1. Coulombic Interaction and Ionic Dissociation; 8.2. Mean Ionic Activity and Activity Coefficient; 8.3. The Debye-Hu?ckel Theory; Problems; 9. Colligative Properties; 9.1. Boiling Point Elevation; 9.2. Freezing Point Depression; 9.3. Osmotic Pressure; 9.4. Isotonicity Calculations; Problems; 10. Solubility; 10.1. Solubility as an Equilibrium Constant; 10.2. The Ideal Solubility; 10.3. Temperature Dependence of the Solubility; 10.4. Solubility of Slightly Soluble Salts; 10.5. Solubilities of Nonelectrolytes: Further Issues; Problems; 11. Surfaces and Interfaces 327 $a11.1. Thermodynamic Properties11.2. Adsorption; Problems; III THERMODYNAMICS OF CHEMICAL PROCESSES; 12. Acid-Base Equilibria; 12.1. Acid-Base Theory; 12.2. pH Dependence of Acid-Base Equilibria; 12.3. Calculation of Solution pH; 12.4. Acid-Base Titrations; 12.5. Aqueous Solubility of Weak Acids and Bases; 12.6. Nonaqueous Acid-Base Behavior; 12.7. Acid-Base Structure and Strength; Problems; 13. Electrical Work; 13.1. Introduction; 13.2. Oxidation-Reduction Reactions; 13.3. Electrochemical Cells; 13.4. pH Measurement; 13.5. Ion-Selective Membrane Electrodes; Problems 327 $a14. Noncovalent Binding Equilibria14.1. Introduction; 14.2. The Noncovalent Interactions; 14.3. Binding Models; 14.4. Measurement of Binding Constants; 14.5. Applications; Problems; APPENDIXES; Appendix A Physical Constants; Appendix B Kinetic Theory of Gases; Appendix C Extrathermodynamic Relationships; ANSWERS TO PROBLEMS; BIBLIOGRAPHY; INDEX 330 $aDesigned for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical laboratory applications. Designed to meet the needs of the contemporary curriculum in pharmacy schools, the text makes these connections clear, emphasizing specific applications to pharmaceutical systems including dosage forms and newer drug delivery systems. Students and practitioners involved in drug discovery, drug delivery, and drug a 606 $aPharmaceutical chemistry 606 $aThermodynamics 608 $aElectronic books. 615 0$aPharmaceutical chemistry. 615 0$aThermodynamics. 676 $a615.19 676 $a615/.19 700 $aConnors$b Kenneth A$g(Kenneth Antonio),$f1932-$066132 701 $aMecozzi$b Sandro$0964698 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457240503321 996 $aThermodynamics of pharmaceutical systems$92188807 997 $aUNINA