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[135]-153. 327 $aEXPLORATIONS IN JAPANESE SOCIOLINGUISTICS; Editorial page; Title page; Copyright page; Dedication; FOREWORD AND ACKNOWLEDGEMENTS; Table of contents; LIST OF FIGURES, TABLES, DIAGRAMS; 1. JAPANESE SOCIOLINGUISTICS - WITH SPECIAL REFERENCE TO WESTERN RESEARCH; 1.1. Japanese language and society; 1.1.1. Japan-related speech-communities; 1.1.2. The Japanese language; 1.1.3. Japanese sociolinguistics as a field of study; 1.2. Encoding social organization; 1.2.1. Verbal honorifics; 1.2.2. Terms of reference and address; 1.3. Social Variation; 1.3.1. Standard and regional varieties 327 $a1.3.1.1. Oral and written varieties1.3.2. Identity markers; 1.3.2.1. Gender; 1.3.2.2. Age markers; 1.3.2.3. Group identity markers; 1.4. Language attitudes; 1.4.1. Language planning; 1.5. Contact between Japanese and other languages in sociolinguistic perspective; 1.5.1. The expansion of Anglo-Japanese; 1.5.2. Japanese-based pidgins; 1.5.3. Japanese overseas communities; 1.5.4. Cross-cultural communication; 1.6. Other topics in Japanese sociolinguistics; 1.7. Conclusion; 2. THE ETHNOGRAPHY OF RITUAL AND ADDRESS AT A WEDDING RECEPTION 327 $a2.1. The reception: setting, participants, activities and functions2.1.1. The organization of speaking; 2.2. The linguistic components of ritual; 2.2.1. Ritual resources at the reception; 2.3. Hierarchical and collective signals: the contextual dynamics of designatory forms; 2.4. A concluding note; 3. SPEAKING OF GIVING: THE PRAGMATICS OF JAPANESE DONATORY VERBS; 4. CROSS-CULTURAL CONTRASTS; 4.1. Pitch, politeness and sexual role; 4.1.1. Pitch; 4.1.1.1. Japanese use of pitch; 4.1.1.2. English use of pitch (British); 4.1.2. Interference; 4.1.3. The investigation; 4.1.3.1. Variables 327 $a4.1.3.2. Results4.1.4. Interpretation of the results; 4.1.4.1. Semantic implications; 4.1.4.2. Sociocultural implications; 4.1.5. Concluding hypothesis; 4.2. Semiotic schism in Japanese-Western interaction; 4.2.1. The concept 'semiotic schism'; 4.2.2. The Japanese case; 4.2.3. Decoding Japanese- Western interaction; 4.2.3.1. Verbal signs; 4.2.3.2. Vocal signs; 4.2.3.3. Kinesic signs; 4.2.3.4. Rhetoric patterns; 4.2.4. The mutual responsibility for miscoding; APPENDIX: Backgroundnotes on Japanese concepts of family and marriage; FOOTNOTES; REFERENCES 330 $aExplorations in Japanese Sociolinguistics provides a treasure of information on the Japanese language and the social and cultural system it has developed and is embedded in. To the non-specialist, it opens an unknown world. To the specialist it offers theoretical and methodological perspectives aimed at avoiding the interference of myth and musing with accurate characterizations. A general introduction on Japanese sociolinguistics is followed by two case studies, one on the ethnography of ritual and address at a Japanese wedding reception, and one on the pragmatics of Japanese donatory 410 0$aPragmatics & beyond ;$vVII:1. 517 1 $aJapanese sociolinguistics 606 $aSociolinguistics$zJapan 608 $aElectronic books. 615 0$aSociolinguistics 676 $a401.90952 676 $a401/.9/0952 700 $aLoveday$b Leo$0686399 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910457172703321 996 $aExplorations in Japanese sociolinguistics$92008732 997 $aUNINA LEADER 00893nam--2200313---450- 001 990006127730203316 005 20160222112913.0 035 $a000612773 035 $aUSA01000612773 035 $a(ALEPH)000612773USA01 035 $a000612773 100 $a20160222d--------km-y0itay50------ba 101 $aita 102 $aIT 105 $aa---||||001yy 200 1 $aCombestiario$fGiuseppe Guglielmi$gillustrazioni di Giovanni Anceschi 210 $aMantova$cEdizioni del verri$d[s.d.] 215 $a25 p.$cill.$d19 cm 676 $a851.91 700 1$aGUGLIELMI,$bGiuseppe$f<1923-1995>$034863 702 1$aANCESCHI,$bGiovanni 801 0$aIT$bsalbc$gISBD 912 $a990006127730203316 951 $aXV.9.Misc. 18$b2042 MAR$cXV.9.Misc.$d385846 959 $aBK 969 $aMAR 979 $aIANNONE$b90$c20160222$lUSA01$h1129 996 $aCombestiario$9164995 997 $aUNISA LEADER 05648nam 2201345z- 450 001 9910566462703321 005 20220506 035 $a(CKB)5680000000037754 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81069 035 $a(oapen)doab81069 035 $a(EXLCZ)995680000000037754 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRecent Developments on Protein-Ligand Interactions$eFrom Structure, Function to Applications 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (282 p.) 311 08$a3-0365-3394-X 311 08$a3-0365-3393-1 330 $aProtein-ligand interactions play a fundamental role in most major biological functions. The number and diversity of small molecules that interact with proteins, whether naturally or not, can quickly become overwhelming. They are as essential as amino acids, nucleic acids or membrane lipids, enabling a large number of essential functions. One need only think of carbohydrates or even just ATP to be certain. They are also essential in drug discovery. With the increasing structural information of proteins and protein-ligand complexes, molecular modelling, molecular dynamics, and chemoinformatics approaches are often required for the efficient analysis of a large number of such complexes and to provide insights. Similarly, numerous computational approaches have been developed to characterize and use the knowledge of such interactions, which can lead to drug candidates. "Recent Developments on Protein-Ligand Interactions: From Structure, Function to Applications" was dedicated to the different aspect of protein-ligand analysis and/or prediction using computational approaches, as well as new developments dedicated to these tasks. It will interest both specialists and non-specialists, as the presented studies cover a very large spectra in terms of methodologies and applications. It underlined the variety of scientific area linked to these questions, i.e., chemistry, biology, physics, informatics, bioinformatics, structural bioinformatics and chemoinformatics. 517 $aRecent Developments on Protein?Ligand Interactions 517 $aRecent Developments on Protein–Ligand Interactions 606 $aBiochemistry$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $a2D interaction maps 610 $a3D-patterns 610 $aacetylcholinesterase 610 $aamino acid conjugation 610 $aamino-X 610 $abenzamide 610 $abiolayer interferometry 610 $abioremediation 610 $abiphenyl-conjugated bromotyrosine 610 $acalcium ions 610 $acaspase inhibition 610 $achemical communication 610 $aclick reaction 610 $aclustering 610 $acomputational analysis of protein-glycosaminoglycan interactions 610 $aconserved patterns 610 $adataset 610 $adocking and scoring 610 $adrug discovery and design 610 $aepigenetics 610 $aflavoprotein 610 $afluorescence polarization 610 $afolate 610 $afolate receptor 610 $afragment-based docking 610 $agalectin-1 610 $aglycosaminoglycans 610 $agulopyranosides 610 $aHigh Energy Molecules 610 $aHMX 610 $aIC50 610 $aimmune checkpoint inhibitors 610 $ain silico docking 610 $ain silico simulation 610 $ainsects 610 $alepidopterous 610 $aligand-binding assays 610 $amacrocyclization 610 $amolecular conformational sampling 610 $amolecular docking 610 $amolecular dynamics 610 $amolecular dynamics (MD) simulation 610 $amolecular modeling 610 $aMonte Carlo sampling 610 $aN-phenyl-1-naphthylamine 610 $anitroreductase 610 $aNMR fragment-based screening 610 $aodorant-binding protein 610 $aorganophosphorus 610 $aPD-1/PD-L1 610 $apeptide conjugation 610 $apesticides 610 $apharmacophore 610 $apharmacophore mapping 610 $apheromone 610 $aphospholipase C gamma 1 610 $apimaricin thioesterase 610 $apre-reaction state 610 $aprocollagen C-proteinase enhancer-1 610 $aprotein design 610 $aprotein-ligand analysis 610 $aprotein-ligand binding free energy 610 $aprotein-ligand complexes 610 $aprotein-ligand interactions 610 $aprotein-RNA interaction 610 $aprotein-substrate interaction 610 $arefinement 610 $aresistance 610 $aRRM domain inhibitor 610 $asecretoglobin 610 $aselective 610 $asimilarity 610 $aSLP76 610 $astructural alignment 610 $astructure-activity relationships 610 $asubstrate specificity 610 $aTDP-43 610 $avirtual screening 615 7$aBiochemistry 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $ade Brevern$b Alexandre G$4edt$01280960 702 $ade Brevern$b Alexandre G$4oth 906 $aBOOK 912 $a9910566462703321 996 $aRecent Developments on Protein-Ligand Interactions$94422380 997 $aUNINA