LEADER 01738nam 2200577Ia 450 001 9910456850603321 005 20200520144314.0 010 $a1-60876-574-1 035 $a(CKB)2550000000010324 035 $a(EBL)3018420 035 $a(SSID)ssj0000412838 035 $a(PQKBManifestationID)12191631 035 $a(PQKBTitleCode)TC0000412838 035 $a(PQKBWorkID)10369492 035 $a(PQKB)10848451 035 $a(MiAaPQ)EBC3018420 035 $a(Au-PeEL)EBL3018420 035 $a(CaPaEBR)ebr10660281 035 $a(OCoLC)610041870 035 $a(EXLCZ)992550000000010324 100 $a20100519d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBioengineering for pollution prevention$b[electronic resource] /$fDianne Ahmann and John R. Dorgan 210 $aNew York $cNova Science$dc2009 215 $a1 online resource (211 p.) 225 1 $aEnvironmental research advances series 300 $aDescription based upon print version of record. 311 $a1-60692-900-3 320 $aIncludes bibliographical references and index. 410 0$aEnvironmental research advances series. 606 $aBioengineering 606 $aBioremediation 606 $aPollution prevention 608 $aElectronic books. 615 0$aBioengineering. 615 0$aBioremediation. 615 0$aPollution prevention. 676 $a628.5 700 $aAhmann$b Dianne$0972374 701 $aDorgan$b John R$0972375 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456850603321 996 $aBioengineering for pollution prevention$92211094 997 $aUNINA LEADER 04583nam 2200373 450 001 9910633980103321 005 20230328075345.0 010 $a1-80355-691-9 035 $a(CKB)5700000000338559 035 $a(NjHacI)995700000000338559 035 $a(EXLCZ)995700000000338559 100 $a20230328d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChagas Disease $eFrom Cellular and Molecular Aspects of Trypanosoma cruzi-Host Interactions to the Clinical Intervention /$fedited by Rubem Menna-Barreto 210 1$aLondon, United Kingdom :$cIntechOpen,$d2022. 215 $a1 online resource (182 pages) $cillustrations 311 $a1-80355-690-0 327 $aPreface -- Section 1 The State of Art -- Chapter 1 Introductory Chapter: Chagas Disease - A Multidisciplinary Old Public Health Problem by Rubem Menna-Barreto -- Section 2 The Treatment -- Chapter 2 New Therapeutics for Chagas Disease: Charting a Course to Drug Approval by Anthony Man and Florencia Segal -- Chapter 3 The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil by Tania C. de Araujo-Jorge, Anna Cristina C. Carvalho, Roberto R. Ferreira, Luciana R. Garzoni, Beatriz M.S. Gonzaga, Marcelo T. Holanda, Gilberto M. Sperandio da Silva, Maria da Gloria Bonecini-Almeida, Mauro F.F. Mediano, Roberto M. Saraiva and Alejandro M. Hasslocher-Moreno -- Chapter 4 Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning by Marcos Andre? Vannier-Santos, Ana Ma?rcia Suarez-Fontes, Juliana Almeida-Silva, Alessandra Lifsitch Vic?osa, Sandra Aurora Chavez Perez, Alejandro Marcel Hasslocher-Moreno, Gabriel Parreiras Estolano da Silveira, Luciana Fernandes Portela and Roberto Magalha?es Saraiva -- Section 3 The Pathogenesis -- Chapter 5 Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon by Vi?ctor Hugo Garci?a Orozco, Juan Enrique Villalvazo Navarro, Carlos Solar Aguirre, Carlos Manuel Ibarra Ocampo, Ce?sar Iva?n Di?az Sandoval, Carlos Alejandro Orti?z Gallegos, Diego Javier Oregel Camacho and Araceli Noriega Bucio -- Chapter 6 How Do Mouse Strains and Inoculation Routes Influence the Course of Experimental Trypanosoma cruzi Infection? by Fla?via de Oliveira Cardoso, Carolina Salles Domingues, Ta?nia Zaverucha do Valle and Ka?tia da Silva Calabrese -- Chapter 7 Modulation of Host Cell Apoptosis by Trypanosoma cruzi: Repercussions in the Development of Chronic Chagasic Cardiomyopathy by Fiordaliso Carolina Roma?n-Carraro, Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodri?guez and Laila Gutie?rrez-Kobeh -- Chapter 8 Evaluation of Molecular Variability of Isolates of Trypanosoma cruzi in the State of Rio de Janeiro-Brazil by Helena Keiko Toma, Luciana Reboredo de Oliveira da Silva, Teresa Cristina Monte Gonc?alves, Renato da Silva Junior and Jacenir R. Santos-Mallet. 330 $aEven 110 years after its discovery, Chagas disease is still an important public health problem, especially in Latin America where it is endemic. The limited effect of current treatments in the chronic phase of the disease, as well as the lack of information about disease progression, are crucial challenges that justify the intense research on this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species and vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features of the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines. This book discusses Chagas disease and its etiological agent, including information on relevant clinical aspects such as diagnosis, treatment, biomarkers, and so on. It also presents information about cellular, molecular, and biochemical characteristics of the parasite-host interactions. 517 $aChagas Disease 606 $aChagas' disease 615 0$aChagas' disease. 676 $a616.9363 702 $aMenna-Barreto$b Rubem 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910633980103321 996 $aChagas Disease$91994004 997 $aUNINA