LEADER 04889nam 2200709 450 001 9910456811603321 005 20200520144314.0 010 $a1-4426-8894-7 024 7 $a10.3138/9781442688940 035 $a(CKB)2550000000019335 035 $a(OCoLC)635459288 035 $a(CaPaEBR)ebrary10382048 035 $a(SSID)ssj0000478731 035 $a(PQKBManifestationID)11291657 035 $a(PQKBTitleCode)TC0000478731 035 $a(PQKBWorkID)10435048 035 $a(PQKB)11044632 035 $a(CaPaEBR)430845 035 $a(CaBNvSL)slc00224347 035 $a(MiAaPQ)EBC3268264 035 $a(MiAaPQ)EBC4672659 035 $a(DE-B1597)465385 035 $a(OCoLC)1013961182 035 $a(OCoLC)944176451 035 $a(DE-B1597)9781442688940 035 $a(Au-PeEL)EBL4672659 035 $a(CaPaEBR)ebr11258315 035 $a(EXLCZ)992550000000019335 100 $a20160923h20082008 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aReading culture and writing practices in nineteenth-century France /$fMartyn Lyons 210 1$aToronto, [Ontario] ;$aBuffalo, [New York] ;$aLondon, [England] :$cUniversity of Toronto Press,$d2008. 210 4$d©2008 215 $a1 online resource (263 p.) 225 1 $aStudies in Book and Print Culture 311 $a0-8020-9357-4 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tContents -- $tTables, Maps, Images -- $tAcknowledgments -- $tAbbreviations -- $t1. Introduction: The Importance of the Nineteenth Century -- $tThe Statistical Approach -- $t2. In Search of the Bestsellers of Nineteenth-Century France, 1815-1850 -- $t3. Towards a National Literary Culture in France: Bookshops and the Decline of the Colporteur -- $tCensorship and Commemoration -- $t4. Fires of Expiation: Book-Burnings and Catholic Missions in Restoration France -- $t5. Literary Commemoration and the Uses of History: The Gutenberg Festival in Strasbourg, 1840 -- $tReaders -- $t6. The Reading Experience of Worker-Autobiographers in Nineteenth-Century Europe -- $t7. Oral Culture and the Rural Community: The Veillée d'Hiver -- $t8. Why We Need an Oral History of Reading -- $tWriters -- $t9. Reading Practices, Writing Practices: Intimate Writings in Nineteenth-Century France -- $t10. French Soldiers and Their Correspondence: Towards a History of Writing Practices in the First World War -- $tAppendix: Calculating Bestsellers in Early Nineteenth-Century France -- $tNotes -- $tSelect Bibliography -- $tIndex 330 $aBetween about 1830 and the outbreak of the First World War, print culture, reading, and writing transformed cultural life in Western Europe in many significant ways. Book production and consumption increased dramatically, and practices such as letter- and diary-writing were widespread. This study demonstrates the importance of the nineteenth century in French cultural change and illustrates the changing priorities and concerns of l'histoire du livre since the 1970s.From the 1830s on, book production experienced an industrial revolution which led to the emergence of a mass literary culture by the close of the century. At the same time, the western world acquired mass literacy. New categories of readers became part of the reading public while western society also learned to write. Reading Culture and Writing Practices in Nineteenth-Century France examines how the concerns of historians have shifted from a search for statistical sources to more qualitative assessments of readers' responses. Martyn Lyons argues that autobiographical sources are vitally important to this investigation and he considers examples of the intimate and everyday writings of ordinary people.Featuring original and intriguing insights as well as references to material hitherto inaccessible to English readers, this study presents a form of 'history from below' with emphasis on the individual reader and writer, and his or her experiences and perceptions. 410 0$aStudies in book and print culture. 606 $aBooks and reading$zFrance$xHistory$y19th century 606 $aWritten communication$zFrance$xHistory$y19th century 606 $aBook industries and trade$zFrance$xHistory$y19th century 606 $aSocial change$zFrance$xHistory$y19th century 608 $aElectronic books. 615 0$aBooks and reading$xHistory 615 0$aWritten communication$xHistory 615 0$aBook industries and trade$xHistory 615 0$aSocial change$xHistory 676 $a028/.9094409034 700 $aLyons$b Martyn$0445753 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456811603321 996 $aReading culture and writing practices in nineteenth-century France$92195667 997 $aUNINA LEADER 05613nam 2200757Ia 450 001 9910826980703321 005 20200520144314.0 010 $a9786612688393 010 $a9781282688391 010 $a1282688391 010 $a9780470561416 010 $a0470561416 010 $a9780470561409 010 $a0470561408 035 $a(CKB)2550000000005941 035 $a(EBL)477779 035 $a(OCoLC)609853664 035 $a(SSID)ssj0000354545 035 $a(PQKBManifestationID)11276005 035 $a(PQKBTitleCode)TC0000354545 035 $a(PQKBWorkID)10314524 035 $a(PQKB)11457422 035 $a(MiAaPQ)EBC477779 035 $a(Au-PeEL)EBL477779 035 $a(CaPaEBR)ebr10360991 035 $a(CaONFJC)MIL268839 035 $a(PPN)243307217 035 $a(OCoLC)1292942762 035 $a(FINmELB)ELB178829 035 $a(Perlego)2765577 035 $a(EXLCZ)992550000000005941 100 $a20090519d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNovel therapeutic targets for anti-arrhythmic drugs /$fedited by George E. Billman 205 $a1st ed. 210 $aHoboken, NJ $cJohn Wiley & Sons$dc2010 215 $a1 online resource (612 p.) 300 $aDescription based upon print version of record. 311 08$a9780470261002 311 08$a0470261005 320 $aIncludes bibliographical references and index. 327 $aNOVEL THERAPEUTIC TARGETS FOR ANTIARRHYTHMIC DRUGS; CONTENTS; Acknowledgments; Contributors; 1. Introduction; References; 2. Myocardial K(+) Channels: Primary Determinants of Action Potential Repolarization; 2.1 Introduction; 2.2 Action Potential Waveforms and Repolarizing K(+) Currents; 2.3 Functional Diversity of Repolarizing Myocardial K(+) Channels; 2.4 Molecular Diversity of K(+) Channel Subunits; 2.5 Molecular Determinants of Functional Cardiac I(to) Channels; 2.6 Molecular Determinants of Functional Cardiac I(K) Channels; 2.7 Molecular Determinants of Functional Cardiac Kir Channels 327 $a2.8 Other Potassium Currents Contributing to Action Potential Repolarization2.8.1 Myocardial K(+) Channel Functioning in Macromolecular Protein Complexes; References; 3. The "Funny" Pacemaker Current; 3.1 Introduction: The Mechanism of Cardiac Pacemaking; 3.2 The "Funny" Current; 3.2.1 Historical Background; 3.2.2 Biophysical Properties of the I(f) Current; 3.2.3 Autonomic Modulation; 3.2.4 Cardiac Distribution of I(f); 3.3 Molecular Determinants of the I(f) Current; 3.3.1 HCN Clones and Pacemaker Channels; 3.3.2 Identification of Structural Elements Involved in Channel Gating 327 $a3.3.3 Regulation of Pacemaker Channel Activity: "Context" Dependence and Protein-Protein Interactions3.3.4 HCN Gene Regulation; 3.4 Blockers of Funny Channels; 3.4.1 Alinidine (ST567); 3.4.2 Falipamil (AQ-A39), Zatebradine (UL-FS 49), and Cilobradine (DK-AH269); 3.4.3 ZD7288; 3.4.4 Ivabradine (S16257); 3.4.5 Effects of the Heart Rate Reducing Agents on HCN Isoforms; 3.5 Genetics of HCN Channels; 3.5.1 HCN-KO Models; 3.5.2 Pathologies Associated with HCN Dysfunctions; 3.6 HCN-Based Biological Pacemakers; References; 4. Arrhythmia Mechanisms in Ischemia and Infarction; 4.1 Introduction 327 $a4.1.1 Modes of Ischemia, Phases of Arrhythmogenesis4.1.2 Trigger-Substrate-Modulating Factors; 4.2 Arrhythmogenesis in Acute Myocardial Ischemia; 4.2.1 Phase 1A; 4.2.2 Phase 1B; 4.2.3 Arrhythmogenic Mechanism: Trigger; 4.2.4 Catecholamines; 4.3 Arrhythmogenesis During the First Week Post MI; 4.3.1 Mechanisms; 4.3.2 The Subendocardial Purkinje Cell as a Trigger 24-48 H Post Occlusion; 4.3.3 Five Days Post-Occlusion: Epicardial Border Zone; 4.4 Arrhythmia Mechanisms in Chronic Infarction; 4.4.1 Reentry and Focal Mechanisms; 4.4.2 Heterogeneity of Ion Channel Expression in the Healthy Heart 327 $a4.4.3 Remodeling in Chronic Myocardial Infarction4.4.4 Structural Remodeling; 4.4.5 Role of the Purkinje System; References; 5. Antiarrhythmic Drug Classification; 5.1 Introduction; 5.2 Sodium Channel Blockers; 5.2.1 Mixed Sodium Channel Blockers (Vaughan Williams Class Ia); 5.3 Inhibitors of the Fast Sodium Current with Rapid Kinetics (Vaughan Williams Class Ib); 5.3.1 Lidocaine; 5.3.2 Mexiletine; 5.4 Inhibitors of the Fast Sodium Current with Slow Kinetics (Vaughan Williams Class Ic); 5.4.1 Flecainide; 5.4.2 Propafenone 327 $a5.5 Inhibitors of Repolarizing K(+) Currents (Vaughan Williams Class III) 330 $aProfiles potential treatment approaches for cardiac arrhythmias Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments f 606 $aMyocardial depressants 606 $aArrhythmia$xChemotherapy 615 0$aMyocardial depressants. 615 0$aArrhythmia$xChemotherapy. 676 $a615.716 676 $a616.128061 701 $aBillman$b George Edward$f1954-$01723738 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826980703321 996 $aNovel therapeutic targets for anti-arrhythmic drugs$94125222 997 $aUNINA