LEADER 04357nam 22008175 450 001 9910456728803321 005 20210907023541.0 010 $a1-282-45846-9 010 $a9786612458460 010 $a1-4008-3058-3 024 7 $a10.1515/9781400830589 035 $a(CKB)2550000000003303 035 $a(EBL)483531 035 $a(OCoLC)609870937 035 $a(SSID)ssj0000417786 035 $a(PQKBManifestationID)11288460 035 $a(PQKBTitleCode)TC0000417786 035 $a(PQKBWorkID)10364557 035 $a(PQKB)10582158 035 $a(DE-B1597)446210 035 $a(OCoLC)979757916 035 $a(DE-B1597)9781400830589 035 $a(MiAaPQ)EBC483531 035 $a(PPN)170241254 035 $a(EXLCZ)992550000000003303 100 $a20190708d2009 fg 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFirst Signals $eThe Evolution of Multicellular Development /$fJohn Tyler Bonner 205 $aCore Textbook 210 1$aPrinceton, NJ :$cPrinceton University Press,$d[2009] 210 4$dİ2001 215 $a1 online resource (159 p.) 300 $aDescription based upon print version of record. 311 $a0-691-07038-5 327 $tFrontmatter --$tCONTENTS --$tPREFACE --$t1. Introduction --$t2. From Embryology to Developmental Biology --$t3. The Origin of Multicellularity --$t4. Size and Evolution --$t5. The Evolution of Signaling --$t6. The Basic Elements of Multicellular Development --$t7. Development in the Cellular Slime Molds --$t8. Conclusion --$tBIBLIOGRAPHY --$tINDEX 330 $aThe enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it. 606 $aCell interaction 606 $aCells -- Evolution 606 $aDevelopmental biology 606 $aDevelopmental cytology 606 $aSignal Transduction 606 $aBiological Evolution 606 $aCell Differentiation 606 $aOrigin of Life 606 $aBiophysics$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 608 $aElectronic books. 615 4$aCell interaction. 615 4$aCells -- Evolution. 615 4$aDevelopmental biology. 615 4$aDevelopmental cytology. 615 12$aSignal Transduction. 615 22$aBiological Evolution. 615 22$aCell Differentiation. 615 22$aOrigin of Life. 615 7$aBiophysics 615 7$aBiology 615 7$aHealth & Biological Sciences 676 $a572.838 700 $aBonner$b John Tyler$032892 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910456728803321 996 $aFirst Signals$92490969 997 $aUNINA