LEADER 03639nam 2200625Ia 450 001 9910456604003321 005 20200520144314.0 010 $a1-280-76129-6 010 $a9786610761296 010 $a0-19-974770-9 035 $a(CKB)2430000000004751 035 $a(EBL)3053705 035 $a(OCoLC)607552687 035 $a(SSID)ssj0000307593 035 $a(PQKBManifestationID)12117792 035 $a(PQKBTitleCode)TC0000307593 035 $a(PQKBWorkID)10244790 035 $a(PQKB)11301535 035 $a(MiAaPQ)EBC3053705 035 $a(Au-PeEL)EBL3053705 035 $a(CaPaEBR)ebr10375305 035 $a(CaONFJC)MIL76129 035 $a(EXLCZ)992430000000004751 100 $a19991104d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRadiation pathology$b[electronic resource] /$fLuis Felipe Fajardo L-G, Morgan Berthrong, Robert E. Anderson 210 $aNew York $cOxford University Press$dc2001 215 $a1 online resource (471 p.) 300 $aDescription based upon print version of record. 311 $a0-19-511023-4 320 $aIncludes bibliographical references and index. 327 $a""Contents""; ""1. Basic radiation, physics, chemistry, and biology""; ""2. Exposures of human populations to ionizing radiation""; ""3. Acute radiation syndromes""; ""4. Mutations and genetic effects""; ""5. Consequences of fetal and childhood exposures""; ""6. Radiation-induced life shortening""; ""7. Radiation and host defense mechanisms""; ""8. Radiation carcinogenesis""; ""9. Diagnostic radiology""; ""10. Techniques and technology in the practice of radiotherapy""; ""11. Overview of radiation injury in organs and tissues""; ""12. Cardiovascular system""; ""HEART""; ""BLOOD VESSELS"" 327 $a""13. Respiratory tract""""LARYNX""; ""LUNG""; ""14. Alimentary tract""; ""ORAL CAVITY AND PHARYNX""; ""ESOPHAGUS""; ""STOMACH""; ""SMALL INTESTINE""; ""LARGE INTESTINE AND ANAL CANAL""; ""15. Liver""; ""16. Pancreas""; ""17. Salivary Glands""; ""18. Urinary system""; ""KIDNEY""; ""URETERS AND URINARY BLADDER""; ""19. Female reproductive organs""; ""20. Mammary glands""; ""THE FEMALE BREAST""; ""THE MALE BREAST""; ""21. Male reproductive organs""; ""TESTIS""; ""PROSTATE""; ""PENIS""; ""22. Endocrine glands""; ""HYPOTHALAMIC-HYPOPHYSEAL AXIS""; ""THYROID""; ""PARATHYROID GLANDS"" 327 $a""ADRENAL GLANDS""""23. Nervous system""; ""CENTRAL NERVOUS SYSTEM""; ""SPINAL CORD""; ""PERIPHERAL NERVES""; ""24. Musculoskeletal system""; ""BONES""; ""SKELETAL MUSCLES""; ""25. Hematopoietic tissue""; ""26. Lymphoreticular system""; ""27. Organs of special senses""; ""EYE AND ITS ADNEXA""; ""EAR""; ""28. Skin""; ""29. Differential diagnosis of atypical cells in irradiated tissues""; ""30. Risk assessment""; ""Epilogue""; ""Index""; ""A""; ""B""; ""C""; ""D""; ""E""; ""F""; ""G""; ""H""; ""I""; ""J""; ""K""; ""L""; ""M""; ""N""; ""O""; ""P""; ""Q""; ""R""; ""S""; ""T""; ""U""; ""V""; ""W"" 327 $a""X"" 606 $aRadiation$xToxicology 606 $aRadiation injuries$xPathophysiology 608 $aElectronic books. 615 0$aRadiation$xToxicology. 615 0$aRadiation injuries$xPathophysiology. 676 $a616.9/897 700 $aFajardo$b Luis Felipe$0917552 701 $aAnderson$b Robert E$g(Robert Edwin),$f1931-2009.$0917553 701 $aBerthrong$b Morgan$0917554 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456604003321 996 $aRadiation pathology$92057221 997 $aUNINA LEADER 02631nam 2200409z- 450 001 9910166647503321 005 20210211 035 $a(CKB)3710000001092124 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44725 035 $a(oapen)doab44725 035 $a(EXLCZ)993710000001092124 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDendritic Cell Control of Immune Responses 210 $cFrontiers Media SA$d2016 215 $a1 online resource (121 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-868-5 330 $aDendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer. 606 $aMedicine$2bicssc 610 $aAutoimmunity 610 $aCancer 610 $aDendritic Cells 610 $aImmune Regulation 610 $aT cells 615 7$aMedicine 676 $a616.07/9 702 $aButterfield$b Lisa Helene 702 $aMorel$b Penelope Anne 906 $aBOOK 912 $a9910166647503321 996 $aDendritic Cell Control of Immune Responses$93033097 997 $aUNINA