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010   $a9786613166289
010   $a3-11-024948-0
024 7 $a10.1515/9783110249484
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035   $a(OCoLC)744520373
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035   $a(OCoLC)840443410
035   $a(DE-B1597)9783110249484
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100   $a20110119d2011      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aImmunodiagnostics and patient safety$b[electronic resource] /$fKrystyna Sztefko
210   $aBerlin $cDe Gruyter$dc2011
215   $a1 online resource (176 p.)
225 1 $aPatient safety ;$vv. 3
300   $aDescription based upon print version of record.
311   $a3-11-024947-2 
320   $aIncludes bibliographical references and index.
327   $aImmunochemical methods : basic principle and definitions -- Immunoassay standardization -- Immunoassay calibration and calibration curve-fitting -- Reference intervals and immunoassay -- Laboratory pre-analytical and analytical phase of immunoassay -- Human natural antibodies and immunoassay -- Immunoassay interferences : how to recognize, eliminate, or reduce them -- Immunoassay and patient safety.
330   $aToday most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.
410  0$aPatient safety ;$vv. 3.
606   $aImmunoassay
606   $aPatients$xSafety measures
608   $aElectronic books.
615  0$aImmunoassay.
615  0$aPatients$xSafety measures.
676   $a616.07/56
700   $aSztefko$b Krystyna$01031755
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910456527103321
996   $aImmunodiagnostics and patient safety$92449247
997   $aUNINA