LEADER 04891nam 2200673 a 450 001 9910456172603321 005 20200520144314.0 010 $a1-280-20397-8 010 $a9786610203970 010 $a0-309-56427-1 010 $a0-585-03808-2 035 $a(CKB)111069351109030 035 $a(EBL)3377126 035 $a(SSID)ssj0000205210 035 $a(PQKBManifestationID)11200651 035 $a(PQKBTitleCode)TC0000205210 035 $a(PQKBWorkID)10192427 035 $a(PQKB)11095424 035 $a(MiAaPQ)EBC3377126 035 $a(Au-PeEL)EBL3377126 035 $a(CaPaEBR)ebr10068358 035 $a(CaONFJC)MIL20397 035 $a(OCoLC)923268432 035 $a(EXLCZ)99111069351109030 100 $a19910325d1991 ua 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMonitoring human tissues for toxic substances$b[electronic resource] /$fCommittee on National Monitoring of Human Tissues, Board on Environmental Studies and Toxoicology, Commission on Life Sciences 210 $aWashington, D.C. $cNational Academy Press$d1991 215 $a1 online resource (224 p.) 300 $aDescription based upon print version of record. 311 $a0-309-04437-5 320 $aIncludes bibliographical references (p. 167-178). 327 $a""Monitoring Human Tissues for Toxic Substances""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""THE NATIONAL HUMAN MONITORING PROGRAM""; ""CHARGE TO THE COMMITTEE""; ""RELATIONSHIP OF TISSUE MONITORING TO EPA PROGRAM PRIORITIES""; ""GOALS AND POTENTIAL USES OF A NATIONAL PROGRAM TO MONITOR HUMAN TISSUES""; ""CONCLUSIONS AND RECOMMENDATIONS""; ""Toxicologic Issues""; ""Relevance of Human Tissue Monitoring to Risk Assessment""; ""Choice of Tissues to Monitor""; ""Sampling Methods""; ""Collection, Short-Term Storage, and Archiving of Tissues"" 327 $a""Chemical Assay of Specimens""""Program Design and Management Issues""; ""Administrative and Agency Issues""; ""Funding""; ""Science Review""; ""Other Administrative Issues""; ""Analysis and Reporting of Data""; ""Cooperation and Information Transfer with Other Organizations""; ""Monitoring Human Tissues for Toxic Substances""; ""1 Introduction ""; ""BACKGROUND""; ""CHARGE TO THE COMMITTEE""; ""ENVIRONMENTAL AND PUBLIC HEALTH RATIONALE FOR MONITORING CHEMICALS IN HUMAN TISSUES""; ""RELATIONSHIP OF TISSUE MONITORING TO EPA PROGRAM PRIORITIES"" 327 $a""GOALS AND POTENTIAL USES OF A NATIONAL PROGRAM TO MONITOR HUMAN TISSUES""""2 Review of the National Human Adipose Tissue Survey and Selected Program Alternatives ""; ""DEVELOPMENT OF THE PROGRAM""; ""Program Deficiencies""; ""Toxicologic Issues (see Chapter 3)""; ""Sampling Strategy (See Chapter 4)""; ""Collection, Storage, and Archiving of Tissues (see Chapter 5)""; ""Chemical Assay Issues (see Chapter 6)""; ""Programmatic Issues (see Chapter 7)""; ""EXISTING PROGRAMS AS POSSIBLE ALTERNATIVES TO THE NATIONAL HUMAN ADIPOSE TISSUE SURVEY"" 327 $a""National Center for Health Statistics: National Health and Nutrition Examination Surveys (NHANES)""""Agency for Toxic Substances and Disease Registry: National Exposure and Disease Registries""; ""National Institute of Standards and Technology: Environmental Specimen Banking Program""; ""Environmental Protection Agency: Total Exposure Assessment Methodology Study""; ""Food and Drug Administration: Total-Diet Study""; ""National Oceanographic and Atmospheric Administration: National Status and Trends Mussel Watch Program""; ""Foreign Programs""; ""Conclusions"" 327 $a""SUMMARY AND RECOMMENDATIONS""""3 Toxicologic Issues ""; ""INTRODUCTION""; ""RELATION BETWEEN ENVIRONMENTAL MONITORING AND TISSUE MONITORING""; ""RELEVANCE OF HUMAN TISSUE MONITORING TO RISK ASSESSMENT""; ""Biologic Markers""; ""Markers of Exposure or Dose""; ""Markers of Effect""; ""Markers of Biologically Effective Dose""; ""Markers of Early Biologic Effect""; ""Markers of Susceptibility""; ""Summary""; ""CHOICE OF TISSUES TO MONITOR""; ""Background""; ""Blood""; ""Adipose Tissue""; ""Lean Tissues""; ""Biologic Fluids""; ""Hair""; ""SUMMARY AND RECOMMENDATIONS""; ""4 Sampling Methods "" 327 $a""INTRODUCTION"" 606 $aBiological monitoring$zUnited States 606 $aBlood$xAnalysis$zUnited States 606 $aAdipose tissues$xAnalysis$zUnited States 606 $aHealth risk assessment 608 $aElectronic books. 615 0$aBiological monitoring 615 0$aBlood$xAnalysis 615 0$aAdipose tissues$xAnalysis 615 0$aHealth risk assessment. 676 $a615.9/07 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456172603321 996 $aMonitoring human tissues for toxic substances$92109260 997 $aUNINA