LEADER 05600nam 2200733 a 450 001 9910456144703321 005 20200520144314.0 010 $a1-282-76002-5 010 $a9786612760020 010 $a1-84816-466-1 035 $a(CKB)2490000000001844 035 $a(EBL)731213 035 $a(OCoLC)670430628 035 $a(SSID)ssj0000416726 035 $a(PQKBManifestationID)12146845 035 $a(PQKBTitleCode)TC0000416726 035 $a(PQKBWorkID)10436642 035 $a(PQKB)11556232 035 $a(MiAaPQ)EBC731213 035 $a(WSP)0000P673 035 $a(Au-PeEL)EBL731213 035 $a(CaPaEBR)ebr10422201 035 $a(CaONFJC)MIL276002 035 $a(EXLCZ)992490000000001844 100 $a20101104d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEmerging topics in physical virology$b[electronic resource] /$feditors, Peter G. Stockley, Reidun Twarock 210 $aLondon $cImperial College Press$d2010 215 $a1 online resource (332 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-464-5 320 $aIncludes bibliographical references and index. 327 $aContributors; Preface; Contents; Chapter 1: Cryo-Electron Microscopy of Viruses Neil A. Ranson and Peter G. Stockley; 1. Introduction; 2. The Cryo-EM Technique; 3. Determining the 3-D Structure of Viruses from EM Data; 4. Complementarity between Cryo-EM versus X-ray Methods; 5. Structure of Large Enveloped Viruses; 6. Virus - Receptor Interactions; 7. Maturation Processes; 8. Structural Information on Packaged Genomes; 9. Prospects for Cryo-EM of Viruses at Atomic Resolution; 10. Pleiomorphic Viruses and the Power of Cryo-Electron Tomography; 11. Conclusions; References 327 $aChapter 2: What Does it Take to Make a Virus: The Concept of the Viral 'Self' Nicola G. A. Abrescia, Jonathan M. Grimes, Elizabeth E. Fry, Janne J. Ravantti, Dennis H. Bamford and David. I. Stuart1. Introduction; 2. Towards the Concept of Viral Lineage?; 3. The Double-Barrel Paradigm Lineage; 4. Picorna-Like Group - Single Barrel, Single Lineage?; 5. More Phages, a Different Lineage; 6. dsRNA Genome - A Constraint on Architecture?; 7. Enveloped Viruses - Infectious Vesicles?; 8. The Viral Self and Emerging Viruses; 9. Conclusions; Acknowledgements; References 327 $aChapter 3: Beyond Quasi-Equivalence: New Insights Into Viral Architecture via Affine Extended Symmetry Groups Thomas Keef and Reidun Twarock1. Introduction - Symmetry in Virus Architecture; 2. The Surface Structures of Viral Capsids: Viral Tiling Theory; 2.1. Quasi-Equivalent Tessellations Beyond Triangulations; 2.2. All-Pentamer Capsids in Viral Tiling Theory; 3. Generalisation of the Symmetry Group via Affine Extension; 4. Applications to Viruses; 4.1. Prediction of Particle Sizes in Assembly Polymorphism; 4.2. Prediction of Genome Organisation; 4.3. Predictions of Protein Structure 327 $a4.4. Implications for Viral Dynamics5. Beyond Virology: Applications to Protein Assemblies with Symmetry; 6. Concluding Remarks -Why is Symmetry Fundamental in Virology?; Acknowledgements; References; Chapter 4: Mechanical Properties of Viruses Wouter H. Roos and Gijs J. L. Wuite; 1. Introduction; 2. Nanoindentation by AFM; 2.1. Sample Preparation; 2.2. Imaging; 2.3. Indenting; 3. Comparing Viral Material Properties; 3.1. Assembly Around the Genome versus Use of a Packaging Motor; 3.2. Influence of Encapsidated Material on Viral Mechanical Properties; 3.3. Capsid Failure; 3.4. Maturation 327 $a3.5. Protein Engineering of Capsids4. Conclusions and Outlook; Acknowledgements; References; Chapter 5: Investigating Viral Structure, Function and Dynamics with Mass Spectrometry Eric B. Monroe and Peter E. Prevelige; 1. Introduction; 2. Mass Spectrometry Overview; 3. The -omics of Viruses; 4. Macromolecular Mass Spectrometry; 5. Structural Studies; 6. Viral Dynamics; 7. Conclusions; References; Chapter 6: An Overview of Capsid Assembly Kinetics J. Zachary Porterfield and Adam Zlotnick; 1. Introduction; 2. Modeling Assembly; 2.1. Stepwise Assembly 327 $a2.2. Contributions of Alternative Pathways to Stepwise Assembly 330 $a""Emerging Topics in Physical Virology"" is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, t 606 $aVirology 606 $aViruses 606 $aViruses$xMorphology 606 $aVirology$xResearch$xMethodology 606 $aVirology$xTechnological innovations 608 $aElectronic books. 615 0$aVirology. 615 0$aViruses. 615 0$aViruses$xMorphology. 615 0$aVirology$xResearch$xMethodology. 615 0$aVirology$xTechnological innovations. 676 $a579.2 701 $aStockley$b Peter G$0980301 701 $aTwarock$b Reidun$0980302 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910456144703321 996 $aEmerging topics in physical virology$92236376 997 $aUNINA