LEADER 01984nam 2200613Ia 450 001 9910455784303321 005 20200520144314.0 010 $a0-7914-8679-6 010 $a1-4175-0686-5 035 $a(CKB)111090529121956 035 $a(OCoLC)61367732 035 $a(CaPaEBR)ebrary10594866 035 $a(SSID)ssj0000146471 035 $a(PQKBManifestationID)11152717 035 $a(PQKBTitleCode)TC0000146471 035 $a(PQKBWorkID)10185959 035 $a(PQKB)10578110 035 $a(MiAaPQ)EBC3408538 035 $a(OCoLC)55140690 035 $a(MdBmJHUP)muse6011 035 $a(Au-PeEL)EBL3408538 035 $a(CaPaEBR)ebr10594866 035 $a(EXLCZ)99111090529121956 100 $a20020715d2003 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEncountering Buddhism$b[electronic resource] $eWestern psychology and Buddhist teachings /$fedited by Seth Robert Segall 210 $aAlbany $cState University of New York Press$d2003 215 $a1 online resource (225 p.) 225 0 $aSUNY series in transpersonal and humanistic psychology 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-7914-5735-4 320 $aIncludes bibliographical references and index. 606 $aBuddhism and psychoanalysis 606 $aPsychotherapy$xReligious aspects$xBuddhism 606 $aSpiritual life$xBuddhism 606 $aBuddhism$zUnited States$xHistory$y20th century 608 $aElectronic books. 615 0$aBuddhism and psychoanalysis. 615 0$aPsychotherapy$xReligious aspects$xBuddhism. 615 0$aSpiritual life$xBuddhism. 615 0$aBuddhism$xHistory 676 $a294.3/375 701 $aSegall$b Seth Robert$01038393 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455784303321 996 $aEncountering Buddhism$92459951 997 $aUNINA LEADER 04504nam 22006375 450 001 9910484242303321 005 20251113174236.0 010 $a3-030-65817-1 024 7 $a10.1007/978-3-030-65817-5 035 $a(CKB)4100000011918907 035 $a(DE-He213)978-3-030-65817-5 035 $a(MiAaPQ)EBC6606571 035 $a(Au-PeEL)EBL6606571 035 $a(OCoLC)1250313038 035 $a(PPN)255882084 035 $a(EXLCZ)994100000011918907 100 $a20210505d2021 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Pulmonary Neuroepithelial Body Microenvironment $eA Multifunctional Unit in the Airway Epithelium /$fby Inge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (XVIII, 99 p. 22 illus., 21 illus. in color.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v233 311 08$a3-030-65816-3 327 $aPulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM. 330 $aThis monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters andare closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v233 606 $aNeurosciences 606 $aPhysiology 606 $aNeurochemistry 606 $aRespiratory organs$xDiseases 606 $aNeuroscience 606 $aPhysiology 606 $aNeurochemistry 606 $aPneumology 615 0$aNeurosciences. 615 0$aPhysiology. 615 0$aNeurochemistry. 615 0$aRespiratory organs$xDiseases. 615 14$aNeuroscience. 615 24$aPhysiology. 615 24$aNeurochemistry. 615 24$aPneumology. 676 $a612.8 700 $aBrouns$b Inge$0894164 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484242303321 996 $aThe Pulmonary Neuroepithelial Body Microenvironment$91997354 997 $aUNINA