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010   $a1-280-22160-7
010   $a9786610221608
010   $a0-309-55769-0
010   $a0-585-15539-9
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035   $a(EBL)3377244
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100   $a19810126d1987      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aPharmacokinetics in risk assessment$b[electronic resource] /$fSubcommittee on Disinfectants and Disinfectant By-Products, Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council
210   $aWashington, D.C. $cNational Academy Press$d1987
215   $a1 online resource (512 p.)
225 0 $aDrinking water and health ;$vv.8
300   $aDescription based upon print version of record.
311   $a0-309-03775-1 
327   $a""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING ""
327   $a""Modeling: An Introduction""""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS""
327   $a""Aerobic Energetics of Muscle In Vivo""""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms""
327   $a""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS""""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters""
327   $a""Approximations of Terminal Half-Lives""""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs;  Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION""
327   $a""Lungs and Skin Administration""
606   $aDrinking water$xContamination$zUnited States
606   $aDrinking water$xContamination
606   $aDrinking water$xHealth aspects$zUnited States
606   $aDrinking water$xHealth aspects
606   $aWater$xPollution$xToxicology
608   $aElectronic books.
615  0$aDrinking water$xContamination
615  0$aDrinking water$xContamination.
615  0$aDrinking water$xHealth aspects
615  0$aDrinking water$xHealth aspects.
615  0$aWater$xPollution$xToxicology.
676   $a333.9122
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910455447303321
996   $aPharmacokinetics in risk assessment$91930755
997   $aUNINA