LEADER 03726nam 2200637Ia 450 001 9910455133003321 005 20200520144314.0 010 $a0-674-02097-9 024 7 $a10.4159/9780674020979 035 $a(CKB)1000000000805550 035 $a(SSID)ssj0000174542 035 $a(PQKBManifestationID)11172648 035 $a(PQKBTitleCode)TC0000174542 035 $a(PQKBWorkID)10176009 035 $a(PQKB)10056818 035 $a(MiAaPQ)EBC3300700 035 $a(Au-PeEL)EBL3300700 035 $a(CaPaEBR)ebr10331285 035 $a(OCoLC)923116712 035 $a(DE-B1597)589740 035 $a(DE-B1597)9780674020979 035 $a(EXLCZ)991000000000805550 100 $a20040809d2004 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHow to win the Nobel Prize$b[electronic resource] $ean unexpected life in science. /$fJ. Michael Bishop 205 $a1st Harvard University Press pbk. ed. 210 $aCambridge, MA ;$aLondon $cHarvard University Press$d2004 215 $axiii, 271 p. $cill 225 1 $aThe Jerusalem-Harvard lectures 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-674-00880-4 311 $a0-674-01625-4 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tContents -- $tList of Illustrations -- $tPreface -- $t1. The Phone Call -- $t2. Accidental Scientist -- $t3. People and Pestilence -- $t4. Opening the Black Box of Cancer -- $t5. Paradoxical Strife -- $tNotes -- $tCredits -- $tIndex 330 $aIn 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer. Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges. Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer. 410 0$aJerusalem-Harvard lectures. 606 $aMedical scientists$zUnited States$vBiography 606 $aOncogenes 606 $aNobel Prizes 608 $aElectronic books. 615 0$aMedical scientists 615 0$aOncogenes. 615 0$aNobel Prizes. 676 $a610.92 700 $aBishop$b J. Michael$f1936-$0866948 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455133003321 996 $aHow to win the Nobel Prize$91935125 997 $aUNINA LEADER 05493nam 22007815 450 001 9910736979503321 005 20260226142053.0 010 $a3-031-28146-2 024 7 $a10.1007/978-3-031-28146-4 035 $a(CKB)27901359200041 035 $a(MiAaPQ)EBC30672173 035 $a(Au-PeEL)EBL30672173 035 $a(DE-He213)978-3-031-28146-4 035 $a(PPN)272271160 035 $a(EXLCZ)9927901359200041 100 $a20230801d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvanced Crop Improvement, Volume 1 $eTheory and Practice /$fedited by Aamir Raina, Mohammad Rafiq Wani, Rafiul Amin Laskar, Nasya Tomlekova, Samiullah Khan 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (546 pages) 311 08$a9783031281457 327 $aPlant Breeding from Classical Genetics to Molecular Approaches for Food and Nutrition Security -- Nanotechnology in Agriculture -- Contribution and Impact of Mutant Varieties on Food Security -- Mutation Breeding: Protocol and Role in crop improvement -- Transgenic Techniques for Plant Improvement: A brief Overview -- Mutagenesis and Transgenesis in Plant Breeding -- Crop Biofortification: Plant Breeding and Biotechnological Interventions to Combat Malnutrition -- In Vitro Techniques in Plant Breeding -- Crop improvement for sustainable food and nutritional security: Applications of mutagenesis and in vitro techniques -- Forward and Reverse Genetics in Crop Breeding -- Genetic mutations and molecular detection techniques in plant breeding -- RNA interference (RNAi) technology: an effective tool in plant breeding -- Doubled Haploid Production- Mechanism and Utilization in Plant Breeding -- TILLING and Eco-Tilling: Concept, Progress and its role in crop improvement -- Genome-Wide Association Study: A Powerful Approach to Map QTLs in Crop Plants -- Genome Editing - Mechanism and Utilization in Plant Breeding -- CRISPR/CAS: The Beginning of a New Era in Crop Improvement -- Next Generation Sequencing in Plant Breeding: Challenges and Possibilities. 330 $aAs per the reports of FAO, the human population will rise to 9 billion by the end of 2050 and 70% of more food must be produced over the next three decades to feed the additional population. The breeding approaches for crop improvement programs are dependent on the availability and accessibility of genetic variation, either spontaneous or induced by the mutagens. Plant breeders, agronomists, and geneticists are under constant pressure to expand food production by employing innovative breeding strategies to enhance yield, adaptability, nutrition, resistance to biotic and abiotic stresses. In conventional breeding approaches, introgression of genes in crop varieties is laborious and time-consuming. Nowadays, new innovative plant breeding techniques such as molecular breeding and plant biotechnology, supplement the traditional breeding approaches to achieve the desired goals of enhanced food production. With the advent of recent molecular tools like genomics, transgenics, molecular marker-assisted back-crossing, TILLING, Eco-TILLING, gene editing, CRISPR CAS, non-targeted protein abundant comparative proteomics, genome wide association studies have made possible mapping of important QTLs, insertion of transgenes, reduction of linkage drags, and manipulation of genome. In general, conventional and modern plant breeding approaches would be strategically ideal for developing new elite crop varieties to meet the feeding requirement of the increasing world population. This book highlights the latest progress in the field of plant breeding, and their applicability in crop improvement. The basic concept of this 2-volume work is to assess the use of modern breeding strategies in supplementing conventional breeding toward the development of elite crop varieties, for obtaining desired goals of food production. 606 $aPlant biotechnology 606 $aPlant genetics 606 $aPlant molecular biology 606 $aAgriculture 606 $aGenetics 606 $aPlant Biotechnology 606 $aPlant Genetics 606 $aPlant Molecular Biology 606 $aAgriculture 606 $aGenetics and Genomics 606 $aPlantes transgèniques$2thub 606 $aEnginyeria genètica vegetal$2thub 606 $aBiotecnologia agrícola$2thub 608 $aLlibres electrònics$2thub 615 0$aPlant biotechnology. 615 0$aPlant genetics. 615 0$aPlant molecular biology. 615 0$aAgriculture. 615 0$aGenetics. 615 14$aPlant Biotechnology. 615 24$aPlant Genetics. 615 24$aPlant Molecular Biology. 615 24$aAgriculture. 615 24$aGenetics and Genomics. 615 7$aPlantes transgèniques 615 7$aEnginyeria genètica vegetal 615 7$aBiotecnologia agrícola 676 $a631.523 700 $aRaina$b Aamir$01381890 701 $aWani$b Mohammad Rafiq$01381891 701 $aLaskar$b Rafiul Amin$01381892 701 $aTomlekova$b Nasya$01381893 701 $aKhan$b Samiullah$01381894 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910736979503321 996 $aAdvanced Crop Improvement, Volume 1$93424727 997 $aUNINA