LEADER 04244nam 2200637Ia 450 001 9910455078703321 005 20200520144314.0 010 $a1-282-50900-4 010 $a9786612509001 010 $a3-211-75123-8 024 7 $a10.1007/978-3-211-75123-7 035 $a(CKB)1000000000804773 035 $a(EBL)510709 035 $a(OCoLC)728699606 035 $a(SSID)ssj0000319022 035 $a(PQKBManifestationID)11279980 035 $a(PQKBTitleCode)TC0000319022 035 $a(PQKBWorkID)10336592 035 $a(PQKB)11454906 035 $a(DE-He213)978-3-211-75123-7 035 $a(MiAaPQ)EBC510709 035 $a(PPN)139948570 035 $a(Au-PeEL)EBL510709 035 $a(CaPaEBR)ebr10338319 035 $a(CaONFJC)MIL250900 035 $a(EXLCZ)991000000000804773 100 $a20080422d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aModern genome annotation$b[electronic resource] $ethe BioSapiens Network /$fDmitrij Frishman, Alfonso Valencia, editors 205 $a1st ed. 2008. 210 $aWien ;$aNew York $cSpringer$dc2009 215 $a1 online resource (506 p.) 300 $aDescription based upon print version of record. 311 $a3-211-75122-X 320 $aIncludes bibliographical references. 327 $aBIOSAPIENS: A European Network of Excellence to develop genome annotation resources -- BIOSAPIENS: A European Network of Excellence to develop genome annotation resources -- Gene definition -- State of the art in eukaryotic gene prediction -- Quality control of gene predictions -- Gene regulation and expression -- Evaluating the prediction of cis-acting regulatory elements in genome sequences -- A biophysical approach to large-scale protein-DNA binding data -- From gene expression profiling to gene regulation -- Annotation and genetics -- Annotation, genetics and transcriptomics -- Functional annotation of proteins -- Resources for functional annotation -- Annotating bacterial genomes -- Data mining in genome annotation -- Modern genome annotation: the BioSapiens network -- Structure to function -- Harvesting the information from a family of proteins -- Protein structure prediction -- Structure prediction of globular proteins -- The state of the art of membrane protein structure prediction: from sequence to 3D structure -- Protein-protein complexes, pathways and networks -- Computational analysis of metabolic networks -- Protein-protein interactions: analysis and prediction -- Infrastructure for distributed protein annotation -- Infrastructure for distributed protein annotation -- Applications -- Viral bioinformatics -- Alternative splicing in the ENCODE protein complement. 330 $aAn accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome. 606 $aBioinformatics 606 $aHuman genome 608 $aElectronic books. 615 0$aBioinformatics. 615 0$aHuman genome. 676 $a572.80285 701 $aFrishman$b Dmitrij$0884002 701 $aValencia$b Alfonso$0884003 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455078703321 996 $aModern genome annotation$91974165 997 $aUNINA