LEADER 02565nam 2200565 a 450 001 9910454796603321 005 20200520144314.0 010 $a1-282-42031-3 010 $a9786612420313 010 $a0-313-34244-X 035 $a(CKB)1000000000765815 035 $a(EBL)497259 035 $a(OCoLC)742332689 035 $a(SSID)ssj0000147832 035 $a(PQKBManifestationID)11135097 035 $a(PQKBTitleCode)TC0000147832 035 $a(PQKBWorkID)10017042 035 $a(PQKB)10653507 035 $a(MiAaPQ)EBC497259 035 $a(Au-PeEL)EBL497259 035 $a(CaPaEBR)ebr10323724 035 $a(EXLCZ)991000000000765815 100 $a20080627d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Enlightenment$b[electronic resource] /$fRonald S. Love 210 $aWestport, Conn. $cGreenwood Press$d2008 215 $a1 online resource (252 p.) 225 1 $aGreenwood guides to historic events, 1500-1900,$x1538-442X 300 $aDescription based upon print version of record. 311 $a0-313-34243-1 320 $aIncludes bibliographical references (p. [187]-203) and index. 327 $aHistorical overview : preliminaries, principles, and preconceptions -- Science and the triumph of reason : Newton, Locke, and a new philosophy -- The philosophes, the church, and Christianity -- The philosophes, political thought, and enlightened despotism -- The alternative vision of Montesquieu and Rousseau. 330 $aOne of the few self-named historical movements, the Enlightenment in 18th-Century Europe was a powerful intellectual reaction to the dominance of absolutist monarchies and religious authorities. Building upon the discoveries of the Scientific Revolution, Enlightenment thinkers--philosophes--set out to improve humanity through reason, knowledge, and experience of the natural world rather than religious doctrine or moral absolutes. Their emphasis on truth through observable phenomena set the standard of thought for the modern age, deeply influencing the areas of government, the modern state, sci 410 0$aGreenwood guides to historic events, 1500-1900. 606 $aEnlightenment 608 $aElectronic books. 615 0$aEnlightenment. 676 $a940.2/5 700 $aLove$b Ronald S.$f1955-2008.$0960178 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910454796603321 996 $aThe Enlightenment$92176242 997 $aUNINA LEADER 04123nam 22007815 450 001 9910298618803321 005 20200701101121.0 010 $a3-319-14962-8 024 7 $a10.1007/978-3-319-14962-2 035 $a(CKB)3710000000359082 035 $a(EBL)1998177 035 $a(SSID)ssj0001451969 035 $a(PQKBManifestationID)11890627 035 $a(PQKBTitleCode)TC0001451969 035 $a(PQKBWorkID)11498446 035 $a(PQKB)11578551 035 $a(DE-He213)978-3-319-14962-2 035 $a(MiAaPQ)EBC1998177 035 $a(PPN)184499240 035 $a(EXLCZ)993710000000359082 100 $a20150216d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells $eMathematical Modeling and Experimental Observations /$fby Iman Tavassoly 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (99 p.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 300 $a"Doctoral thesis accepted by Virginia Polytechnic Institute and State University, USA." 311 $a3-319-14961-X 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code. 330 $aThis interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aBiomaterials 606 $aBioinformatics 606 $aCancer$xResearch 606 $aCytology 606 $aBiophysics 606 $aBiophysics 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 606 $aComputational Biology/Bioinformatics$3https://scigraph.springernature.com/ontologies/product-market-codes/I23050 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 615 0$aBiomaterials. 615 0$aBioinformatics. 615 0$aCancer$xResearch. 615 0$aCytology. 615 0$aBiophysics. 615 0$aBiophysics. 615 14$aBiomaterials. 615 24$aComputational Biology/Bioinformatics. 615 24$aCancer Research. 615 24$aCell Biology. 615 24$aBiological and Medical Physics, Biophysics. 676 $a571.936 700 $aTavassoly$b Iman$4aut$4http://id.loc.gov/vocabulary/relators/aut$0974039 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298618803321 996 $aDynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells$92217256 997 $aUNINA