LEADER 03899nam 22006374a 450 001 9910454603303321 005 20200520144314.0 010 $a0-262-28209-7 010 $a1-4356-9409-0 035 $a(CKB)1000000000705952 035 $a(EBL)3338963 035 $a(SSID)ssj0000229717 035 $a(PQKBManifestationID)11199515 035 $a(PQKBTitleCode)TC0000229717 035 $a(PQKBWorkID)10172574 035 $a(PQKB)10331705 035 $a(StDuBDS)EDZ0000130696 035 $a(MiAaPQ)EBC3338963 035 $a(OCoLC)300235040$z(OCoLC)503443543$z(OCoLC)646770521$z(OCoLC)694516328$z(OCoLC)961534620$z(OCoLC)962631100$z(OCoLC)974444433$z(OCoLC)974513155 035 $a(OCoLC-P)300235040 035 $a(MaCbMITP)7590 035 $a(Au-PeEL)EBL3338963 035 $a(CaPaEBR)ebr10256731 035 $a(OCoLC)300235040 035 $a(EXLCZ)991000000000705952 100 $a20071130d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtocells$b[electronic resource] $ebridging nonliving and living matter /$fedited by Steen Rasmussen ... [et al.] 210 $aCambridge, Mass. $cMIT Press$dc2009 215 $a1 online resource (723 p.) 300 $aDescription based upon print version of record. 311 $a0-262-18268-8 320 $aIncludes bibliographical references and index. 327 $aContents ; Preface; Acknowledgments; Introduction; I OVERVIEW: BRIDGING NONLIVING AND LIVING MATTER; 1 The Early History of Protocells: The Search for the Recipe of Life; 2 Experimental Approaches to Fabricating Artificial Cellular Life; 3 Semisynthetic Minimal Cells: New Advancements and Perspectives; 4 A Roadmap to Protocells; II INTEGRATION; 5 Steps Toward a Synthetic Protocell; 6 Assembly of a Minimal Protocell; 7 Population Analysis of Liposomes with Protein Synthesis and a Cascading Genetic Network; 8 Constructive Approach to Protocells: Theory and Experiments 327 $a9 Origin of Life and Lattice Artificial Chemistry10 Models of Protocell Replication; 11 Compositional Lipid Protocells: Reproduction without Polynucleotides; 12 Evolutionary Microfluidic Complementation Toward Artificial Cells; III COMPONENTS; 13 Self-Replication and Autocatalysis; 14 Replicator Dynamics in Protocells; 15 Peptide Nucleic Acids as Prebiotic and Abiotic Genetic Material; 16 The Core of a Minimal Gene Set: Insights from Natural Reduced Genomes; 17 Parasitism and Protocells:Tragedy of the Molecular Commons 327 $a18 Forming the Essential Template for Life: The Physics of Lipid Self- Assembly19 Numerical Methods for Protocell Simulations; 20 Core Metabolism as a Self-Organized System; 21 Energetics, Energy Flow, and Scaling in Life; IV BROADER CONTEXT; 22 Ganti's Chemoton Model and Life Criteria; 23 Viral Individuality and Limitations of the Life Concept; 24 Nonlinear Chemical Dynamics and the Origin of Life: The Inorganic-Physical Chemist Point of View; 25 Early Ancestors of Existing Cells; 26 Prebiotic Chemistry, the Primordial Replicator, and Modern Protocells 327 $a27 Cell-like Entities: Scientific Challenges and Future Applications28 Social and Ethical Issues Concerning Protocells; Glossary; About the Authors; Index; Color Plates 330 8 $aThe first comprehensive general resource on state-of-the-art protocell research, describing current approaches to making new forms of life from scratch in the laboratory. 606 $aArtificial cells 606 $aLife (Biology) 608 $aElectronic books. 615 0$aArtificial cells. 615 0$aLife (Biology) 676 $a576.8/3 701 $aRasmussen$b Steen$0961651 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910454603303321 996 $aProtocells$92180213 997 $aUNINA