LEADER 04230nam 22006492 450 001 9910454564303321 005 20160204162552.0 010 $a1-107-11124-2 010 $a0-511-32253-4 010 $a0-511-54529-0 010 $a1-280-15359-8 010 $a0-511-11725-6 010 $a0-511-14904-2 010 $a0-511-05148-4 010 $a9786610153596 035 $a(CKB)111056485623592 035 $a(EBL)144652 035 $a(OCoLC)437072463 035 $a(SSID)ssj0000104449 035 $a(PQKBManifestationID)11646038 035 $a(PQKBTitleCode)TC0000104449 035 $a(PQKBWorkID)10079748 035 $a(PQKB)10737626 035 $a(UkCbUP)CR9780511545290 035 $a(MiAaPQ)EBC144652 035 $a(Au-PeEL)EBL144652 035 $a(CaPaEBR)ebr10064630 035 $a(CaONFJC)MIL15359 035 $a(EXLCZ)99111056485623592 100 $a20090507d2000|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAplastic anemia $epathophysiology and treatment /$fedited by Hubert Schrezenmeier and Andrea Bacigalupo$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2000. 215 $a1 online resource (xii, 391 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-64101-2 311 $a0-511-01752-9 320 $aIncludes bibliographical references and index. 327 $aPreliminaries; Contents; Contributors; Preface; 1 Stem cell defect in aplastic anemia; 2 Cytokine abnormalities in aplastic anemia; 3 Role of T-lymphocytes in the pathophysiology of aplastic anemia; 4 Role of apoptosis in the pathophysiology of aplastic anemia; 5 The interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria; 6 Aplastic anemia and other clonal disorders; 7 Epidemiology and etiology of aplastic anemia; 8 Clinical presentation, natural course, and prognostic factors; 9 Supportive treatment of patients with severe aplastic anemia 327 $a10 Immunosuppressive treatment of aplastic anemia11 Role of cytokines in the treatment of aplastic anemia; 12 HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia; 13 Alternative donor bone marrow transplantation for severe acquired aplastic anemia; 14 Treatment of children with acquired aplastic anemia; 15 Long-term follow-up of patients with aplastic anemia: clonal malignant and nonmalignant complications; 16 Guidelines for treating aplastic anemia; 17 Clinical features and diagnosis of Fanconi's anemia; 18 Genetic basis of Fanconi's anemia 327 $a19 Treatment of Fanconi's anemia20 Genetic correction of Fanconi's anemia; Index 330 $aThis book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as a detailed overview of the pathophysiology of the disease, the international team of authors cover all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconi's anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference. 606 $aAplastic anemia 615 0$aAplastic anemia. 676 $a616.1/52 702 $aSchrezenmeier$b H$g(Hubert), 702 $aBacigalupo$b A. 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910454564303321 996 $aAplastic anemia$92451060 997 $aUNINA