LEADER 04107nam 2200673 a 450 001 9910454346203321 005 20200520144314.0 010 $a1-281-93583-2 010 $a9786611935832 010 $a981-279-543-X 035 $a(CKB)1000000000537856 035 $a(DLC)2003276531 035 $a(StDuBDS)AH24685188 035 $a(SSID)ssj0000251539 035 $a(PQKBManifestationID)11188694 035 $a(PQKBTitleCode)TC0000251539 035 $a(PQKBWorkID)10171136 035 $a(PQKB)11200817 035 $a(MiAaPQ)EBC1681729 035 $a(WSP)00005099 035 $a(Au-PeEL)EBL1681729 035 $a(CaPaEBR)ebr10255524 035 $a(CaONFJC)MIL193583 035 $a(OCoLC)815752565 035 $a(EXLCZ)991000000000537856 100 $a20030827d2002 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStochastic dynamics of reacting biomolecules$b[electronic resource] /$fWerner Ebeling, Lutz Schimansky-Geier, Yuri M. Romanovsky 210 $aRiver Edge, N.J. $cWorld Scientific$dc2002 215 $a1 online resource (xxiii, 318 p. ) $cill 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a981-238-162-7 320 $aIncludes bibliographical references and index. 327 $ach. 1. Introduction to the reaction theory and cluster dynamics of enzymes / W. Ebeling, A. Netrebko, Yu. Romanovsky -- ch. 2. Tools of stochastic dynamics / L. Schimansky-Geier and P. Talkner -- ch. 3. Motion of test particles in a 2-d potential landscape / O.A. Chichigina, A.V. Netrebko, and N.V. Netrebko -- ch. 4. Microscopic simulations of activation and dissociation / W. Ebeling ... [et al.] -- ch. 5. Excitations on rings of molecules / A. Chetverikov ... [et al.] -- ch. 6. Fermi resonance and Kramers problem in 2-d force field / S.V. Kroo ... [et al.] -- ch. 7. Molecular scissors. Cluster model of acetylcholinesterase / A.Yu. Chikishev ... [et al.] -- ch. 8. Dynamics of proton transfer in the active site of chymotrypsin / A.Yu. Chikishev, B.A. Grishanin and E.V. Shuvalova -- ch. 9. On the damping of cluster oscillations in protein molecules / A.Yu. Chikishev, A.V. Netrebko, and Yu.M. Romanovsky -- ch. 10. Protein dynamics and new approaches to the molecular mechanisms of protein functioning / K.V. Shaitan -- ch. 11. Conclusions. 330 $aThis is a book about the physical processes in reacting complex molecules, particularly biomolecules. In the past decade scientists from different fields such as medicine, biology, chemistry and physics have collected a huge amount of data about the structure, dynamics and functioning of biomolecules. Great progress has been achieved in exploring the structure of complex molecules. However, there is still a lack of understanding of the dynamics and functioning of biological macromolecules. In particular this refers to enzymes, which are the basic molecular machines working in living systems. This book contributes to the exploration of the physical mechanisms of these processes, focusing on critical aspects such as the role of nonlinear excitations and of stochastic effects. An extensive range of original results has been obtained in the last few years by the authors, and these results are presented together with a comprehensive survey of the state of the art in the field. 606 $aPhysical biochemistry 606 $aStochastic processes 606 $aBiomolecules$xReactivity 606 $aBiomolecules$xStructure 608 $aElectronic books. 615 0$aPhysical biochemistry. 615 0$aStochastic processes. 615 0$aBiomolecules$xReactivity. 615 0$aBiomolecules$xStructure. 676 $a572.8633 700 $aEbeling$b Werner$f1936-$0881898 701 $aSchimansky-Geier$b Lutz$f1950-$061264 701 $aRomanovsky$b Yuri M$0881899 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910454346203321 996 $aStochastic dynamics of reacting biomolecules$91969901 997 $aUNINA