LEADER 05566nam 2200673Ia 450 001 9910454184903321 005 20200520144314.0 010 $a1-282-73750-3 010 $a9786612737503 010 $a0-08-093272-X 035 $a(CKB)1000000000577411 035 $a(EBL)428487 035 $a(OCoLC)437112372 035 $a(SSID)ssj0000137819 035 $a(PQKBManifestationID)12053677 035 $a(PQKBTitleCode)TC0000137819 035 $a(PQKBWorkID)10096484 035 $a(PQKB)10655567 035 $a(MiAaPQ)EBC428487 035 $a(Au-PeEL)EBL428487 035 $a(CaPaEBR)ebr10286080 035 $a(CaONFJC)MIL273750 035 $a(EXLCZ)991000000000577411 100 $a20080919d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDeveloping solid oral dosage forms$b[electronic resource] $epharmaceutical theory and practice /$fexecutive editors, Yihong Qiu, Yisheng Chen, Geoff G.Z. Zhang ; associate editors, Linong Liu, William R. Porter 205 $a1st ed. 210 $aAmsterdam ;$aBoston ;$aLondon $cAcademic$d2009 215 $a1 online resource (976 p.) 300 $aDescription based upon print version of record. 311 $a0-444-53242-0 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice; Copyright Page; Contents; List of Contributors; Foreword; PART I: THEORIES AND TECHNIQUES IN THE CHARACTERIZATION OF DRUG SUBSTANCES AND EXCIPIENTS; Chapter 1. Solubility of Pharmaceutical Solids; 1.1 Introduction; 1.1.1 Implication of Solubility in Dosage Form Development; 1.1.2 Basic Concepts of Solubility and Dissolution; 1.2 Thermodynamics of Solutions; 1.2.1 Volume of Mixing; 1.2.2 Enthalpy of Mixing; 1.2.3 Entropy of Mixing; 1.2.4 Free Energy of Mixing; 1.3 Theoretical Estimation of Solubility 327 $a1.3.1 Ideal Solutions1.3.2 Effect of Crystallinity; 1.3.3 Non-ideal Solutions; 1.3.4 Regular Solution Theory; 1.3.5 Aqueous Solution Theory; 1.3.6 The General Solubility Equation (GSE); 1.4 Solubilization of Drug Candidates; 1.4.1 Solubility Enhancement by pH Control and Salt Formation; 1.4.2 Solubilization Using Complexation; 1.4.3 Solubilization by Cosolvents; 1.4.4 Solubilization by Surfactants (Micellar Solubilization); 1.4.5 Solubilization by Combination of Approaches; 1.5 Experimental Determination of Solubility; 1.5.1 Stability of Solute and Solvent; 1.5.2 Shakers and Containers 327 $a1.5.3 Presence of Excess Undissolved Solute1.5.4 Determination of Equilibrium; 1.5.5 Phase-separation; 1.5.6 Determination of Solute Content in the Dissolved Phase; 1.5.7 Experimental Conditions; Chapter 2. Crystalline and Amorphous Solids; 2.1 Introduction; 2.2 Definitions and Categorization of Solids; 2.3 Thermodynamics and Phase Diagrams; 2.3.1 Polymorphs; 2.3.2 Solvates/Hydrates; 2.3.3 Cocrystals; 2.3.4 Amorphous Solids; 2.4 Pharmaceutical Relevance and Implications; 2.4.1 Solubility; 2.4.2 Dissolution Rate and Bioavailability; 2.4.3 Hygroscopicity; 2.4.4 Reactivity and Chemical Stability 327 $a2.4.5 Mechanical Properties2.5 Transformations Among Solids; 2.5.1 Induced by Heat; 2.5.2 Induced by Vapor; 2.5.3 Induced by Solvents; 2.5.4 Induced by Mechanical Stresses; 2.6 Methods of Generating the Solids; 2.6.1 Through Gas; 2.6.2 Through Liquid; 2.6.3 Through Solid; 2.7 Amorphous Drugs and Solid Dispersions; 2.7.1 Characteristics of Amorphous Phases; 2.7.2 Characteristics of Amorphous Solid Dispersions; 2.7.3 Crystallization of Amorphous Drug and Dispersions; 2.8 Special Topics; 2.8.1 Polymorph Screening and Stable Form Screening; 2.8.2 High Throughput Crystallization 327 $a2.8.3 Miniaturization in CrystallizationChapter 3. Analytical Techniques in Solid-state Characterization; 3.1 Introduction; 3.2 Review of Analytical Techniques and Methods; 3.3 Microscopic Methods; 3.3.1 Optical Microscopy; 3.3.2 Electron Microscopy; 3.4 Thermal Analysis; 3.4.1 Differential Scanning Calorimetry; 3.4.2 Thermogravimetric Analysis; 3.4.3 Microcalorimetry; 3.5 Diffraction Methods; 3.5.1 Single-crystal X-ray Diffraction; 3.5.2 Powder X-ray Diffraction; 3.6 Vibrational Spectroscopy; 3.6.1 Infrared Spectroscopy; 3.6.2 Raman Spectroscopy; 3.6.3 Near-infrared 327 $a3.7 Solid-State Nuclear Magnetic Resonance Spectroscopy 330 $aThis book is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern 606 $aSolid dosage forms 606 $aSolid dosage forms$xResearch 608 $aElectronic books. 615 0$aSolid dosage forms. 615 0$aSolid dosage forms$xResearch. 676 $a615.19 701 $aQiu$b Yihong$0988984 701 $aChen$b Yisheng$0988985 701 $aZhang$b Geoff G. Z$0988986 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910454184903321 996 $aDeveloping solid oral dosage forms$92261579 997 $aUNINA