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010   $a9786611307530
010   $a92-4-068250-3
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035   $a(OCoLC)213772602
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035   $a(PQKBTitleCode)TC0000306860
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100   $a20081023d2006      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aPrinciples and methods for assessing autoimmunity associated with exposure to chemicals$b[electronic resource] /$ffirst draft prepared by the World Health Organization Collaborating Centre for Immunotoxicology and Allergic Hypersensitivity at the National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, in conjunction with an international group of experts
210   $aGeneva $cWorld Health Organization$d2006
215   $a1 online resource (359 p.)
225 1 $aEnvironmental health criteria,$x0250-863X ;$v236
300   $a"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
311   $a92-4-157236-1 
320   $aIncludes bibliographical references.
327   $aTITLE; COPYRIGHT; CONTENTS; NOTE TO READERS OF THE CRITERIA MONOGRAPHS; PREAMBLE; WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA ON PRINCIPLES AND METHODS FOR ASSESSING AUTOIMMUNITY ASSOCIATED WITH EXPOSURE TO CHEMICALS; ACRONYMS AND ABBREVIATIONS; 1. SUMMARY; 2. INTRODUCTION AND DEFINITIONS OF AUTOIMMUNITY AND AUTOIMMUNE DISEASE; 3. INTRODUCTION TO THE IMMUNE SYSTEM: FOCUS ON AUTOIMMUNE MECHANISMS; 4. INTRINSIC FACTORS IN AUTOIMMUNITY; 5. CLINICAL EXPRESSION OF HUMAN AUTOIMMUNE DISEASES; 6. EPIDEMIOLOGY; 7. MECHANISMS OF CHEMICAL-ASSOCIATED AUTOIMMUNE RESPONSES
327   $a8. CHEMICAL/PHYSICAL AGENTS AND AUTOIMMUNITY9. NON-CHEMICAL FACTORS IN AUTOIMMUNITY; 10. ANIMAL MODELS TO ASSESS CHEMICAL-INDUCED AUTOIMMUNITY; 11. HUMAN TESTING FOR AUTOIMMUNE DISEASE; 12. RISK ASSESSMENT; 13. CONCLUSIONS AND RECOMMENDATIONS; TERMINOLOGY; REFERENCES; RESUME; RESUMEN; 
330   $aThis new volume in the Environmental Health Criteria series provides a framework for the evaluation of the role of chemical risk factors in the development of autoimmune diseases. In addition to a general introduction to autoimmune mechanisms and clinical expression of autoimmune diseases, a discussion of mechanisms of chemical-associated autoimmune responses precedes information on a range of chemical and other agents. Animal models and human testing for autoimmune disease and the application of information in risk assessment are presented. This book will be useful to biology and toxicology s
410  0$aEnvironmental health criteria ;$v236.
606   $aAutoimmunity
606   $aAutoimmune diseases$xDiagnosis
606   $aOrganic compounds
606   $aInorganic compounds
608   $aElectronic books.
615  0$aAutoimmunity.
615  0$aAutoimmune diseases$xDiagnosis.
615  0$aOrganic compounds.
615  0$aInorganic compounds.
676   $a616.97807
712 02$aWorld Health Organization.$bCollaborating Centre for Immunotoxicology and Allergic Hypersensitivity.
712 02$aInter-Organization Programme for the Sound Management of Chemicals.
712 02$aInternational Labour Organisation.
712 02$aWorld Health Organization.
712 02$aInternational Program on Chemical Safety.
712 02$aUnited Nations Environment Programme.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910454183803321
996   $aPrinciples and methods for assessing autoimmunity associated with exposure to chemicals$92073033
997   $aUNINA