LEADER 05038nam 2200685Ia 450 001 9910454078003321 005 20200520144314.0 010 $a1-281-95608-2 010 $a9786611956080 010 $a981-279-669-X 035 $a(CKB)1000000000537895 035 $a(EBL)1681633 035 $a(OCoLC)815755899 035 $a(SSID)ssj0000201641 035 $a(PQKBManifestationID)11184391 035 $a(PQKBTitleCode)TC0000201641 035 $a(PQKBWorkID)10245481 035 $a(PQKB)10196587 035 $a(MiAaPQ)EBC1681633 035 $a(WSP)00005298 035 $a(Au-PeEL)EBL1681633 035 $a(CaPaEBR)ebr10255556 035 $a(EXLCZ)991000000000537895 100 $a20030721d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMetal ions and neurodegenerative disorders$b[electronic resource] /$feditor, Paolo Zatta 210 $aNew Jersey $cWorld Scientific$dc2003 215 $a1 online resource (538 p.) 300 $aDescription based upon print version of record. 311 $a981-238-398-0 320 $aIncludes bibliographical references and index. 327 $aContents ; Preface ; List of Contributors ; Chapter 1. Metal-Catalyzed Redox Activity in Neurodegenerative Disease ; 1. INTRODUCTION ; 1.1. Redox-Active Transition Metals in AD ; 1.2. Aggregation of Amyloid-B and Amyloid B Protein Precursor/Amyloid-p-Linked ROS Production 327 $a1.3. Iron in Neurodegenerative Disease 1.4. Iron-Mediated Oxidative Stress in Parkinson's Disease ; 1.5. Manganese and Parkinson's Disease ; 1.6. Antioxidant and Transition Metal Homeostasis ; 1.7. CuZnSOD Mutations and Familial Amyotrophic Lateral Sclerosis ; 2. CONCLUSIONS 327 $aChapter 2. Metals Distribution and Regionalization in the Brain 1. TRACE ELEMENT DISTRIBUTION IN NORMAL HUMAN BRAIN ; 1.1. Aluminum Iron Copper and Zinc Distribution in Normal Human Brain Sites in Relation to Age ; 1.2. Aluminum ; 1.3. Iron ; 1.4. Copper ; 1.5. Zinc 327 $a2. TRACE ELEMENT IMBALANCES IN NEURODEGENERATIVE DISEASES 2.1. Aluminum Iron Copper and Zinc in Alzheimer's Disease ; 2.2. Factors Affecting the Final Results ; 2.3. Aluminum Iron Copper and Zinc in Parkinson's Disease 327 $a2.4. Aluminum Iron Copper and Zinc in Western Pacific Parkinsonism-Dementia 2.5. Aluminum Iron Copper and Zinc in Amyotrophic Lateral Sclerosis ; 3. FINAL REMARKS ; Chapter 3. The Olfactory Pathway as a Route of Entry of Metals into the Brain ; 1. INTRODUCTION 327 $a2. ANATOMY OF THE OLFACTORY SYSTEM 330 $a Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences 606 $aMetal ions$xPhysiological effect 606 $aMolecular neurobiology 606 $aNervous system$xDegeneration 606 $aNeurotoxicology 608 $aElectronic books. 615 0$aMetal ions$xPhysiological effect. 615 0$aMolecular neurobiology. 615 0$aNervous system$xDegeneration. 615 0$aNeurotoxicology. 676 $a616.80471 701 $aZatta$b Paolo$0307116 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910454078003321 996 $aMetal ions and neurodegenerative disorders$92075634 997 $aUNINA LEADER 05826nam 22007933u 450 001 9910146741103321 005 20220114125135.0 010 $a1-282-34294-0 010 $a9786612342943 010 $a0-470-72712-8 010 $a0-470-72713-6 035 $a(CKB)1000000000520026 035 $a(EBL)470287 035 $a(OCoLC)232611467 035 $a(SSID)ssj0000303232 035 $a(PQKBManifestationID)11210476 035 $a(PQKBTitleCode)TC0000303232 035 $a(PQKBWorkID)10275320 035 $a(PQKB)10373254 035 $a(MiAaPQ)EBC470287 035 $a(EXLCZ)991000000000520026 100 $a20160215d2008|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMicrostructural Characterization of Materials$b[electronic resource] 205 $a2nd ed. 210 $aHoboken $cWiley$d2008 215 $a1 online resource (554 p.) 225 0 $aQuantitative software engineering series Microstructural characterization of materials 300 $aDescription based upon print version of record. 311 $a0-470-02784-3 327 $aMicrostructural Characterization of Materials; Contents; Preface to the Second Edition; Preface to the First Edition; 1 The Concept of Microstructure; 1.1 Microstructural Features; 1.1.1 Structure-Property Relationships; 1.1.2 Microstructural Scale; 1.1.3 Microstructural Parameters; 1.2 Crystallography and Crystal Structure; 1.2.1 Interatomic Bonding in Solids; 1.2.2 Crystalline and Amorphous Phases; 1.2.3 The Crystal Lattice; Summary; Bibliography; Worked Examples; Problems; 2 Diffraction Analysis of Crystal Structure; 2.1 Scattering of Radiation by Crystals 327 $a2.1.1 The Laue Equations and Bragg's Law2.1.2 Allowed and Forbidden Reflections; 2.2 Reciprocal Space; 2.2.1 The Limiting Sphere Construction; 2.2.2 Vector Representation of Bragg's Law; 2.2.3 The Reciprocal Lattice; 2.3 X-Ray Diffraction Methods; 2.3.1 The X-Ray Diffractometer; 2.3.2 Powder Diffraction-Particles and Polycrystals; 2.3.3 Single Crystal Laue Diffraction; 2.3.4 Rotating Single Crystal Methods; 2.4 Diffraction Analysis; 2.4.1 Atomic Scattering Factors; 2.4.2 Scattering by the Unit Cell; 2.4.3 The Structure Factor in the Complex Plane 327 $a2.4.4 Interpretation of Diffracted Intensities2.4.5 Errors and Assumptions; 2.5 Electron Diffraction; 2.5.1 Wave Properties of Electrons; 2.5.2 Ring Patterns, Spot Patterns and Laue Zones; 2.5.3 Kikuchi Patterns and Their Interpretation; Summary; Bibliography; Worked Examples; Problems; 3 Optical Microscopy; 3.1 Geometrical Optics; 3.1.1 Optical Image Formation; 3.1.2 Resolution in the Optical Microscope; 3.1.3 Depth of Field and Depth of Focus; 3.2 Construction of the Microscope; 3.2.1 Light Sources and Condenser Systems; 3.2.2 The Specimen Stage; 3.2.3 Selection of Objective Lenses 327 $a3.2.4 Image Observation and Recording3.3 Specimen Preparation; 3.3.1 Sampling and Sectioning; 3.3.2 Mounting and Grinding; 3.3.3 Polishing and Etching Methods; 3.4 Image Contrast; 3.4.1 Reflection and Absorption of Light; 3.4.2 Bright-Field and Dark-Field Image Contrast; 3.4.3 Confocal Microscopy; 3.4.4 Interference Contrast and Interference Microscopy; 3.4.5 Optical Anisotropy and Polarized Light; 3.4.6 Phase Contrast Microscopy; 3.5 Working with Digital Images; 3.5.1 Data Collection and The Optical System; 3.5.2 Data Processing and Analysis; 3.5.3 Data Storage and Presentation 327 $a3.5.4 Dynamic Range and Digital Storage3.6 Resolution, Contrast and Image Interpretation; Summary; Bibliography; Worked Examples; Problems; 4 Transmission Electron Microscopy; 4.1 Basic Principles; 4.1.1 Wave Properties of Electrons; 4.1.2 Resolution Limitations and Lens Aberrations; 4.1.3 Comparative Performance of Transmission and Scanning Electron Microscopy; 4.2 Specimen Preparation; 4.2.1 Mechanical Thinning; 4.2.2 Electrochemical Thinning; 4.2.3 Ion Milling; 4.2.4 Sputter Coating and Carbon Coating; 4.2.5 Replica Methods; 4.3 The Origin of Contrast; 4.3.1 Mass-Thickness Contrast 327 $a4.3.2 Diffraction Contrast and Crystal Lattice Defects 330 $aMicrostructural characterization is usually achieved by allowing some form of probe to interact with a carefully prepared specimen. The most commonly used probes are visible light, X-ray radiation, a high-energy electron beam, or a sharp, flexible needle. These four types of probe form the basis for optical microscopy, X-ray diffraction, electron microscopy, and scanning probe microscopy.

Microstructural Characterization of Materials, 2nd Edition is an introduction to the expertise involved in assessing the microstructure of engineering materials and to the experimental met 606 $aElectronic books. -- local 606 $aMaterials -- Microscopy 606 $aMicrostructure 606 $aMaterials$xMicroscopy 606 $aMicrostructure 606 $aMaterials Science$2HILCC 606 $aChemical & Materials Engineering$2HILCC 606 $aEngineering & Applied Sciences$2HILCC 608 $aElectronic books. 615 4$aElectronic books. -- local. 615 4$aMaterials -- Microscopy. 615 4$aMicrostructure. 615 0$aMaterials$xMicroscopy 615 0$aMicrostructure 615 7$aMaterials Science 615 7$aChemical & Materials Engineering 615 7$aEngineering & Applied Sciences 676 $a620.1/1299 700 $aBrandon$b David$0747018 701 $aKaplan$b Wayne D$0747019 701 $aBrandon$b D. G$0968053 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910146741103321 996 $aMicrostructural Characterization of Materials$92198566 997 $aUNINA