LEADER 04457nam 2200697 a 450 001 9910453989203321 005 20200520144314.0 010 $a1-282-49377-9 010 $a9786612493775 010 $a0-7391-3175-3 035 $a(CKB)1000000000785898 035 $a(StDuBDS)AH23062214 035 $a(SSID)ssj0000777179 035 $a(PQKBManifestationID)12369952 035 $a(PQKBTitleCode)TC0000777179 035 $a(PQKBWorkID)10766706 035 $a(PQKB)10832463 035 $a(SSID)ssj0000142866 035 $a(PQKBManifestationID)12003491 035 $a(PQKBTitleCode)TC0000142866 035 $a(PQKBWorkID)10097576 035 $a(PQKB)11369333 035 $a(MiAaPQ)EBC467224 035 $a(Au-PeEL)EBL467224 035 $a(CaPaEBR)ebr10353707 035 $a(CaONFJC)MIL249377 035 $a(OCoLC)435630948 035 $a(EXLCZ)991000000000785898 100 $a20090106d2009 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEcocritical explorations in literary and cultural studies$b[electronic resource] $efences, boundaries, and fields /$fPatrick D. Murphy 210 $aLanham $cLexington Books$dc2009 215 $a1 online resource (230 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-7391-3174-5 311 $a0-7391-3173-7 320 $aIncludes bibliographical references (p. 193-207) and index. 327 $aChapter 1 Introduction Part 2 Climbing Through Conceptual Fences Chapter 3 The Complexity of Simplicity Chapter 4 Difference and Responsibility in Literary Alternatives to Nation State Chapter 5 Paradise or a Pair of Dice: Contradictions and Contingencies in Real and Virtual Terrains for Tomorrow's College Students Chapter 6 Toward Transnational Ecocritical Theory: The Example of Hwa Yol Jung Part 7 Surveying the Boundaries of Genre Chapter 8 Nature in the Contemporary American Novel Chapter 9 The Non-alibi of Alien Scapes: SF and Ecocriticism Chapter 10 The Non-alibi of Pragmatic Utopianism and Wild Variability; or, Optimistic Variations on a Science Fiction Theme Chapter 11 Mysteries of Nature and Environmental Justice Part 12 Culturally Crossing the Field Chapter 13 Nature Nurturing Fathers in a World beyond our Control Chapter 14 Scenarios of Disaster: Crying Wolf, Scaring away the Elephants, and Heading 'Em off at the Pass Chapter 15 Hurricanes and Hubris Chapter 16 Ranging Widely to Find Home 330 8 $aIn Ecocritical Explorations, Patrick D. Murphy explores environmental literature and environmental cultural issues through both theoretical and applied criticism. He engages with the concepts of referentiality, simplicity, the nation state, and virtual reality in the first section of the book, and then goes on to interrogate these issues in contemporary environmental literature, both American and international. He concludes his argument with a discussion of the larger frames of family dynamics and un-natural disasters, such as hurricanes and global warming, ending with a chapter on the integration of scholarship and pedagogy in the classroom, with reference to his own teaching experiences. Murphy's study provides a wide ranging discussion of contemporary literature and cultural phenomena through the lens of ecological literary criticism, giving attention to both theoretical issues and applied critiques. In particular, he looks at popular literary genres, such as mystery and science fiction, as well as actual disasters and disaster scenarios. Ecocritical Explorations in Literary and Cultural Studies is a timely contribution to ecological literary criticism and an insightful look into how we represent our relationship with the environment. 606 $aAmerican literature$xHistory and criticism 606 $aEcocriticism 606 $aEcology in literature 606 $aPhilosophy of nature in literature 608 $aElectronic books. 615 0$aAmerican literature$xHistory and criticism. 615 0$aEcocriticism. 615 0$aEcology in literature. 615 0$aPhilosophy of nature in literature. 676 $a810.9/355 700 $aMurphy$b Patrick D.$f1951-$0291288 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453989203321 996 $aEcocritical explorations in literary and cultural studies$92294929 997 $aUNINA LEADER 01079nam 2200301Ia 450 001 996384448103316 005 20221108051901.0 035 $a(CKB)1000000000596214 035 $a(EEBO)2240871192 035 $a(OCoLC)17812358 035 $a(EXLCZ)991000000000596214 100 $a19880419d1693 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA just enquiry into the libeller's abuse of the people called Quakers$b[electronic resource] $ein his scandalous pamphlet, falsly stiled, Some of the Quakers principles, doctrines, laws and orders, &c 210 $aLondon $cPrinted and sold by T. Sowle ...$d1693 215 $a[2], 30 p 300 $aAttributed to Whitehead by Wing. 300 $aReproduction of original in the Cambridge University Library. 330 $aeebo-0021 700 $aWhitehead$b George$f1636?-1723.$01000951 801 0$bEAH 801 1$bEAH 801 2$bWaOLN 906 $aBOOK 912 $a996384448103316 996 $aA just enquiry into the libeller's abuse of the people called Quakers$92407737 997 $aUNISA LEADER 06613nam 2200673Ia 450 001 9910437616203321 005 20200520144314.0 010 $a1-283-63399-X 010 $a9786613946447 010 $a94-007-4694-6 024 7 $a10.1007/978-94-007-4694-7 035 $a(CKB)2560000000091187 035 $a(EBL)994558 035 $a(OCoLC)809770929 035 $a(SSID)ssj0000739641 035 $a(PQKBManifestationID)11473222 035 $a(PQKBTitleCode)TC0000739641 035 $a(PQKBWorkID)10697519 035 $a(PQKB)11183035 035 $a(DE-He213)978-94-007-4694-7 035 $a(MiAaPQ)EBC994558 035 $a(PPN)168338726 035 $a(EXLCZ)992560000000091187 100 $a20120910h20122013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTumor ablation $eeffects on systemic and local anti-tumor immunity and on other tumor-microenvironment /$fYona Keisari, editor 205 $a1st ed. 2013. 210 $aDordrecht ;$aNew York $cSpringer$d2012, c2013 215 $a1 online resource (160 p.) 225 0 $aThe tumor microenvironment ;$v5 300 $aDescription based upon print version of record. 311 $a94-007-9932-2 311 $a94-007-4693-8 320 $aIncludes bibliographical references and index. 327 $aPreface; Contents; Chapter 1 Effect of Chemotherapy on the Tumor Microenvironment and Anti-tumor Immunity; 1.1 Introduction; 1.2 Mechanisms of Cell Death Induced by Anti-cancer Therapy; 1.2.1 Apoptosis; 1.2.2 Non-apoptotic Cell Death; 1.2.3 Morphological vs Functional Classification of Cell Death; 1.3 Immunogenicity of Cell Death; 1.4 Biochemical Features of Immunogenic Cell Death; 1.4.1 Calreticulin Exposure; 1.4.2 Heat Shock Proteins (HSPs); 1.4.3 HMGB1 and TLR Interactions; 1.4.4 ATP Release and Activation of the NLRP3 Inflammasome; 1.4.5 Autophagy-Dependent Immune Responses 327 $a1.5 Effects of Chemotherapy on the Immune System1.5.1 Immune-Suppressive Effects; 1.5.1.1 Lymphopenia; 1.5.1.2 Non-immunogenic Cell Death; 1.5.2 Immune-Stimulatory Effects; 1.5.2.1 Enhanced Antigen Delivery and Presentation; 1.5.2.2 Homeostatic Proliferation; 1.5.2.3 Regulatory T Cells; 1.5.2.4 Myeloid Derived Suppressor Cells (MDSCs); 1.5.2.5 DNA-Damage Response and Activation of the Innate Immune System; 1.5.2.6 Gemcitabine; 1.5.2.7 5-Fluorouracil (5FU); 1.5.3 Immune-Modulatory Effects of Targeted Agents; 1.5.3.1 Imatinib; 1.5.3.2 Sunitinib and Sorafenib; 1.6 Conclusion; References 327 $aChapter 2 Hyperthermia, the Tumor Microenvironment and Immunity2.1 Introduction; 2.2 Hyperthermia; 2.2.1 Fever Range Heating (FRH); 2.2.2 Hyperthermia Range Heating; 2.2.3 Ablation Range Hyperthermia; 2.3 Conclusions; References; Chapter 3 Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ Tumor Vaccines; 3.1 Introduction; 3.2 RFA Techniques/Parameters and Tumor Cell Death; 3.2.1 Direct Effects; 3.2.2 Indirect Effects; 3.3 Release of Immune-Mediating Factors and `Immunogenic' Cell Death; 3.3.1 Release of Tumor-Antigens; 3.3.2 Release of Immune Stimulating Mediators 327 $a3.4 Induction of Immune Responses by RFA: The Tumor Microenvironment3.4.1 Antigen Presentation after Radio Frequency Ablation; 3.4.2 Immunity after Radiofrequency Ablation; 3.4.3 Regulation after Radiofrequency Ablation; 3.5 RFA Combinational Strategies; 3.5.1 Tumor Cytotoxicity; 3.5.2 Immunotherapy; 3.5.2.1 Stimulation of Antigen Presentation; 3.5.2.2 Stimulation of T Cell Reactivity; 3.6 Conclusions and Future Perspective; References; Chapter 4 High Intensity Focused Ultrasound (HIFU) Ablation; 4.1 History of HIFU Tumor Ablation; 4.2 Physical Principles of HIFU Ablation 327 $a4.3 Technical Aspects of HIFU Ablation4.4 Direct Thermal and Non-thermal Effects on the Tumor; 4.5 Thermal Effects on Tumor Vasculature; 4.6 Indirect Effects on the Tumor; 4.7 HIFU-Induced Antitumor Immune Response; 4.8 Conclusions; References; Chapter 5 The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects; 5.1 Introduction; 5.2 Clinical Use of Cryoablation in Cancer; 5.3 Anecdotal Evidence of Immune Response to Cryoablation; 5.4 How Does Cryoablation Kill Tumors?; 5.4.1 Direct Cellular Injury 327 $a5.4.2 Indirect Cellular Injury 330 $aThe growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity. The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities. 410 0$aThe Tumor Microenvironment ;$v5 606 $aCancer$xThermotherapy 606 $aImmune system$xPathophysiology 615 0$aCancer$xThermotherapy. 615 0$aImmune system$xPathophysiology. 676 $a616.9940632 700 $aKeisari$b Yona$01757506 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437616203321 996 $aTumor ablation$94195381 997 $aUNINA