LEADER 02939nam 2200649 450 001 9910453772803321 005 20200520144314.0 010 $a1-119-95207-7 010 $a1-118-52607-4 010 $a1-118-52601-5 010 $a1-118-52606-6 035 $a(CKB)2550000001256700 035 $a(EBL)1662189 035 $a(SSID)ssj0001180119 035 $a(PQKBManifestationID)11707588 035 $a(PQKBTitleCode)TC0001180119 035 $a(PQKBWorkID)11199478 035 $a(PQKB)11649907 035 $a(MiAaPQ)EBC1662189 035 $a(MiAaPQ)EBC4036073 035 $a(DLC) 2013049079 035 $a(Au-PeEL)EBL1662189 035 $a(CaPaEBR)ebr10856814 035 $a(OCoLC)875820294 035 $a(EXLCZ)992550000001256700 100 $a20140414h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular and cellular toxicology $ean introduction /$fDr. Lesley A. Stanley 210 1$aChichester, England :$cWiley Blackwell,$d2014. 210 4$dİ2014 215 $a1 online resource (435 p.) 300 $aDescription based upon print version of record. 311 $a1-119-95206-9 311 $a1-306-57172-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aBackground to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques. 330 $a Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which 606 $aToxicity Tests$vMethods 606 $aMolecular biology 606 $aXenobiotics$xtoxicity 608 $aElectronic books. 615 0$aToxicity Tests 615 0$aMolecular biology. 615 0$aXenobiotics$xtoxicity. 676 $a615.9/07 700 $aStanley$b Lesley$0898450 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453772803321 996 $aMolecular and cellular toxicology$92007407 997 $aUNINA