LEADER 05445nam 2200673 450 001 9910453586003321 005 20200520144314.0 010 $a0-12-398520-X 035 $a(CKB)2550000001136785 035 $a(EBL)1495643 035 $a(OCoLC)861559611 035 $a(SSID)ssj0001141488 035 $a(PQKBManifestationID)11631426 035 $a(PQKBTitleCode)TC0001141488 035 $a(PQKBWorkID)11093565 035 $a(PQKB)11434274 035 $a(MiAaPQ)EBC1495643 035 $a(PPN)178539961$9sudoc 035 $a(PPN)182565688$9sudoc 035 $a(PPN)17723881X 035 $a(Au-PeEL)EBL1495643 035 $a(CaPaEBR)ebr10787025 035 $a(CaONFJC)MIL536487 035 $a(EXLCZ)992550000001136785 100 $a20131123d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRegenerative medicine applications in organ transplantation /$fedited by Giuseppe Orlando [and three others] 210 1$aLondon :$cElsevier Science,$d2014. 215 $a1 online resource (1050 p.) 300 $aIncludes index. 311 $a0-12-398523-4 311 $a1-306-05236-X 327 $aFront Cover; Regenerative Medicine Applications in Organ Transplantation; Copyright Page; Dedication; Contents; Meet the Editors; List of Contributors; Preface; 1 Introduction: Regenerative Medicine and Solid Organ Transplantation from a Historical Perspective; 1.1 Introduction; 1.2 Major Advances in Organ Transplantation; 1.2.1 Vascular Reconstruction; 1.2.2 Organ Preservation; 1.2.3 Artificial Support; 1.2.4 Immunosuppression; 1.2.5 Operational Tolerance; 1.2.6 Organ Recovery and Definition of Brain Death; 1.2.7 Living Donation; 1.2.8 HLA Typing and Crossmatch; 1.3 Regenerative Medicine 327 $a1.3.1 A New Term in Transplantation: Regenerative Medicine1.3.2 Characteristics of Regenerative Tissues; 1.3.3 Polymer Development; 1.3.4 Early Tissue Development; 1.3.5 Cell Source; 1.3.6 Soft Tissue Regeneration as Applied to Battlefield Medicine; 1.3.7 Planar Acellular Dermal Matrices; 1.3.8 Vascularization of Tissue-Engineered Organs; 1.3.9 Perfusion Decellularization, Using Nature's Vascular Network; 1.3.10 Specific Organ Transplantation History and Link to Engineering; 1.3.10.1 Liver; 1.3.10.2 Kidney; 1.3.10.3 Heart; 1.3.10.4 Lung; 1.3.10.5 Pancreas; 1.3.10.6 Intestine 327 $a1.3.11 Concluding RemarksReferences; 2 Solid Organ Transplantation: Has the Promise Been Kept and the Needs Met?; 2.1 Introduction; 2.2 Tolerance in organ transplantation; 2.2.1 Tolerogenic Approaches; 2.2.1.1 T-Cell Depletion; 2.2.1.2 Costimulation Blockade; 2.2.1.3 B-Cell Therapies; 2.2.1.4 Chimerism; 2.2.1.5 Regulatory T Cells; 2.2.1.6 Maintenance IS; 2.2.2 Spontaneous Operational Tolerance; 2.2.3 Biomarkers of Operationally Tolerant Transplant Recipients; 2.3 Organ shortage; 2.3.1 Strategies to Increase the Donor Pool; 2.3.1.1 Increasing the Donation Rates 327 $a2.3.1.2 Greater Use of Deceased Potential Donors2.3.1.3 Splitting Livers; 2.3.1.4 Living Donation; 2.3.1.5 Improved Use of Organs; 2.3.1.6 Xenotransplantation; 2.4 Conclusions; Abbreviations; References; I: Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering; 3 Strategies for the Specification of Tissue Engineering Biomaterials; 3.1 Introduction: the Engineering Approach to Tissue Regeneration; 3.2 Principles of Biomaterials Selection in Tissue Engineering; 3.2.1 The Concept of Tissue Engineering Templates; 3.2.2 The Objectives of Tissue Engineering Templates 327 $a3.2.3 Classification of Tissue Engineering Templates3.2.4 Specifications for Template Materials; 3.2.4.1 Mandatory Specifications; 3.2.4.2 Optional/Application-Specific Requirements; 3.3 Specific Types of Template Material; 3.3.1 Porous Solids; 3.3.2 Hydrogels; 3.3.3 ECM-Derived Materials; 3.4 Concluding Comments; Author's Note; References; 4 Principles of Stem Cell Biology; 4.1 The Origin of the Cell Reprogramming; 4.2 Somatic Cell Nuclear Transfer; 4.2.1 SCNT in Amphibians; 4.2.2 SCNT in Mammals; 4.3 Cell Fusion; 4.3.1 The Transcription Factors Induce Cell Lineage Switch 327 $a4.4 Transcription Factor Transduction: iPS Cell Generation 330 $a Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine an 606 $aRegenerative medicine 606 $aTissue engineering 606 $aTransplantation of organs, tissues, etc 608 $aElectronic books. 615 0$aRegenerative medicine. 615 0$aTissue engineering. 615 0$aTransplantation of organs, tissues, etc. 676 $a617.954 701 $aOrlando$b Giuseppe$068300 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453586003321 996 $aRegenerative medicine applications in organ transplantation$92169116 997 $aUNINA