LEADER 04136nam 2200613Ia 450 001 9910453409703321 005 20200520144314.0 010 $a1-281-90476-7 010 $a9786611904760 010 $a3-7643-8373-9 035 $a(CKB)1000000000546827 035 $a(EBL)417753 035 $a(OCoLC)304494965 035 $a(SSID)ssj0000209390 035 $a(PQKBManifestationID)11194191 035 $a(PQKBTitleCode)TC0000209390 035 $a(PQKBWorkID)10266890 035 $a(PQKB)10793934 035 $a(DE-He213)978-3-7643-8373-2 035 $a(MiAaPQ)EBC417753 035 $a(PPN)130186295 035 $a(Au-PeEL)EBL417753 035 $a(CaPaEBR)ebr10267040 035 $a(CaONFJC)MIL190476 035 $a(EXLCZ)991000000000546827 100 $a20080709d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe network collective$b[electronic resource] $erise and fall of a scientific paradigm /$fKlaus Eichmann 205 $a1st ed. 2008. 210 $aBasel ;$aBoston $cBirkha?user$dc2008 215 $a1 online resource (279 p.) 300 $aDescription based upon print version of record. 311 $a3-7643-8372-0 320 $aIncludes bibliographical references and index. 327 $aAutobiographical note -- Autobiographical note -- Scientific Knowledge, Delusive or Deductive -- Realism, constructivism, and the naiveté of the experimental scientist -- Beyond underdeterminism: Popper, Kuhn, et al. -- The anthropology of science: Ludwik Fleck et al. -- The science wars -- Origins, Rise, and Fall of the Network Paradigm -- The immune system, pre-network paradigms -- The necessity for an interactive theory of immunity -- Proto-ideas of the network theory: antibody self-regulation, idiotypy, the brain analogy, and cybernetics -- The idiotypic network theory -- The T cell receptor puzzle -- Suppression turned idiotypic -- Network mannerism -- Post-network immunology: Idiotypic network continues at the bedside -- Hindsight -- Science between Fact and Fiction -- The fictional nature of scientific notions -- Fiction turned fact: The case of antibodies -- The enticing network: Fiction forever -- Logic and laws in life science. 330 $aThe network paradigm dominated immunological research from the early 1970's to the late 1980's. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an exciting new perspective of the immune system is now viewed as a scientific vagary, and is largely abandoned. The author, himself a participant in the network vagary, begins with a description of the leading theoretical concepts on fact finding in science. This is followed by a historical account of the rise and fall of the network paradigm, complemented by personal interviews with some of the prominent protagonists. By comparing the network paradigm to other, more lasting concepts in life science, the author develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality. 606 $aIdiotypic networks 606 $aImmune system$xResearch$xHistory 608 $aElectronic books. 615 0$aIdiotypic networks. 615 0$aImmune system$xResearch$xHistory. 676 $a616.079 700 $aEichmann$b Klaus$f1939-$0887738 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453409703321 996 $aThe network collective$91983020 997 $aUNINA