LEADER 05654nam 2200721 450 001 9910453380703321 005 20200520144314.0 010 $a1-4557-7676-9 035 $a(CKB)2550000001168884 035 $a(EBL)1576657 035 $a(OCoLC)865334317 035 $a(SSID)ssj0001141550 035 $a(PQKBManifestationID)11631429 035 $a(PQKBTitleCode)TC0001141550 035 $a(PQKBWorkID)11090656 035 $a(PQKB)10627651 035 $a(MiAaPQ)EBC1576657 035 $a(Au-PeEL)EBL1576657 035 $a(CaPaEBR)ebr10817782 035 $a(CaONFJC)MIL550170 035 $a(EXLCZ)992550000001168884 100 $a20131230d2014 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular sensors and nanodevices $eprinciples, designs and applications in biomedical engineering /$fJohn X. J. Zhang, Kazunori Hoshino 210 1$aWaltham, Massachusetts ;$aOxford, England :$cWilliam Andrew,$d2014. 210 4$dİ2014 215 $a1 online resource (512 p.) 225 1 $aMicro & Nano Technologies Series 300 $aDescription based upon print version of record. 311 $a1-4557-7631-9 311 $a1-306-18919-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Molecular Sensors and Nanodevices; Copyright Page; Contents; About the Authors; Preface; Acknowledgement; 1 Introduction to Molecular Sensors; 1.1 Introduction; 1.2 Principles of Molecular Sensors; 1.2.1 Definition of Molecular Sensors; Capture and Recognition; Transduction; Measurement and Analysis; 1.2.2 Applications of Molecular Sensors; 1.2.3 Model of a Molecular Sensor; Capture and Recognition; Transduction; Measurement and Analysis; 1.2.4 Example of Molecular Sensor 1: Immunosensor Based on Field Effect Transistor; Capture and Recognition Elements; Transducer 327 $aMeasurement and Analysis 1.2.5 Example of Molecular Sensor 2: Animal Olfactory System; 1.3 Capture and Recognition Elements in Molecular Sensors; 1.3.1 Antibody-Antigen Binding; Antibody Overview; Antibody-Antigen Binding; Immunoassays; 1.3.2 DNA as a Recognition Element; Discovery of DNA; DNA Structure and Characteristics; RNA Function; DNA Hybridization; Oligonucleotides; Nucleic Acid Sensors; 1.3.3 Aptamers; Aptamer Selection Process; Example Process: Bead Based Selection; 1.4 Transduction Mechanisms; 1.4.1 Electrical Transduction; Optical Transduction; Mechanical Transduction 327 $a1.4.2 Sensitivity of a Transducer Responsivity; Noise in a Sensing System; Sensitivity; Thermal Noise; Example 1; Example 2; Example 3; 1.5 Performance of Molecular Sensors; 1.6 Animals as Molecular Sensors; 1.6.1 Sensitivity of Animal Olfactory Systems; Canine Olfactory System; Insect Olfactory System; 1.6.2 Applications of Animal Molecular Sensors; Explosive Detection; Canine Detection of Explosives; Pouched Rats for the Detection of Landmines; Honeybees for the Detection of Landmines; Disease Detection; Canines for Cancer Detection; Pouched Rats for the Detection of Tuberculosis 327 $aOther Applications Canine Detection of Pirated DVDs; Canine Detection of Bed Bugs; 1.6.3 Discussion on Animals as Molecular Sensors; 1.7 Conclusion; Problems; P1.1 Molecular Sensor; P1.2 Molecular Sensor; P1.3 Recognition Element; P1.4 Basics of Molecular Sensing; P1.5 Antibodies; P1.6 Immunosensing; P1.7 DNA Biosensor; P1.8 DNA Basics; P1.9 DNA Basics; P1.10 DNA Basics; P1.11 DNA Basics; P1.12 Thermal Noise; P1.13 Thermal Noise, Responsivity and Sensitivity; P1.14 Sensitivity of a Force Sensor; P1.15 Animals as Molecular Sensors; References; Further Reading 327 $a2 Fundamentals of Nano/Microfabrication and Effect of Scaling 2.1 Introduction; 2.2 Scaling in Molecular Sensors; 2.3 Microfabrication Basics; 2.3.1 Silicon as a Material for Microfabrication; Silicon Crystal Structure; 2.3.2 Photolithography; Process of Photolithography; Resolution of Photolithography; Contact and Proximity Exposure; Projection Exposure; 2.3.3 Deposition; Spin Coating; Thermal Oxidation; Evaporation; E-beam Evaporation; Resistive Heat (Joule Heat) Evaporation; Problems Associated with Evaporation; Sputtering; Chemical Vapor Deposition; Polysilicon; Amorphous silicon 327 $aSilicon Dioxide 330 $aWith applications ranging from medical diagnostics to environmental monitoring, molecular sensors (also known as biosensors, chemical sensors, or chemosensors), along with emerging nanotechnologies offer not only valuable tools but also unlimited possibilities for engineers and scientists to explore the world. New generation of functional microsystems can be designed to provide a variety of small scale sensing, imaging and manipulation techniques to the fundamental building blocks of materials. This book provides comprehensive coverage of the current and emerging technologies of molecular sens 410 0$aMicro & nano technologies. 606 $aBiosensors 606 $aDetectors 606 $aNanoelectronics 606 $aNanostructured materials$xElectric properties 608 $aElectronic books. 615 0$aBiosensors. 615 0$aDetectors. 615 0$aNanoelectronics. 615 0$aNanostructured materials$xElectric properties. 676 $a610.28 700 $aZhang$b John X. J$0948331 701 $aHoshino$b Kazunori$0948332 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453380703321 996 $aMolecular sensors and nanodevices$92143408 997 $aUNINA