LEADER 03693nam 2200649Ia 450 001 9910453196403321 005 20200520144314.0 010 $a1-281-82586-7 010 $a9786611825867 010 $a0-19-971871-7 035 $a(CKB)1000000000550291 035 $a(EBL)415493 035 $a(OCoLC)476242783 035 $a(SSID)ssj0000192555 035 $a(PQKBManifestationID)11166091 035 $a(PQKBTitleCode)TC0000192555 035 $a(PQKBWorkID)10196693 035 $a(PQKB)10094099 035 $a(SSID)ssj0001146713 035 $a(PQKBManifestationID)12437825 035 $a(PQKBTitleCode)TC0001146713 035 $a(PQKBWorkID)11129752 035 $a(PQKB)11406989 035 $a(MiAaPQ)EBC415493 035 $a(Au-PeEL)EBL415493 035 $a(CaPaEBR)ebr10254425 035 $a(CaONFJC)MIL182586 035 $a(EXLCZ)991000000000550291 100 $a20080130d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLincoln and his admirals$b[electronic resource] $eAbraham Lincoln, the U.S. Navy, and the Civil War /$fCraig L. Symonds 210 $aOxford ;$aNew York $cOxford University Press$d2008 215 $a1 online resource (445 p.) 300 $aDescription based upon print version of record. 311 $a0-19-975157-9 311 $a0-19-531022-5 320 $aIncludes bibliographical references (p. 407-416) and index. 327 $aContents; Acknowledgments; Introduction; 1861: GETTING UNDER WAY; 1. "What Have I Done Wrong?": Lincoln and the Fort Sumter Crisis; 2. "A Competent Force": Lincoln and the Blockade; 3. "No Affront to the British Flag": Lincoln and the Trent Affair; 1862: CHARTING A COURSE; 4. "Rain the Rebels Out": Lincoln and the River War; 5. "It Strikes Me There's Something in It": Lincoln and the Monitor; 6. "We Cannot Escape History": Lincoln and the Contrabands; 1863: TROUBLED WATERS; 7. "The Peninsula All Over Again": Lincoln, Charleston, and Vicksburg 327 $a8. "I Shall Have to Cut This Knot": Lincoln as Adjudicator9. "Peace Does Not Appear So Distant as It Did": Lincoln and Wartime Politics; 1864: FULL SPEED AHEAD; 10. "A Worthy Object": Lincoln and the Red River Campaign; 11. "A Vote of Thanks": Lincoln and the Politics of Promotion; 12. "I Must Refer You to General Grant": Lincoln Relinquishes the Conn; 1865: FINAL HARBOR; Epilogue: "Thank God That I Have Lived to See This": Lincoln and the End of the War; Abbreviations Used in Notes; Notes; Bibliography; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; Y 330 $aIn 1952, T. Harry Williams wrote the classic study, Lincoln and His Generals. Half a century later, Craig Symonds will write its necessary follow-up, Lincoln and His Admirals - a much-needed history of the Union navy during the Civil War. Given the wealth of books on the military history of the Civil War, surprisingly little has been written about the role of the navy. As Symonds shows, Abraham Lincoln began his presidency as well as the war with virtually no knowledge of naval affairs, lacking both exposure and interest given his upbringing in the Midwest. Despite his inexperience, he quickly 606 $aPresidents$zUnited States$vBiography 607 $aUnited States$xHistory$yCivil War, 1861-1865$xNaval operations 608 $aElectronic books. 615 0$aPresidents 676 $a973.7092B 700 $aSymonds$b Craig L$0516874 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453196403321 996 $aLincoln and his admirals$92063384 997 $aUNINA LEADER 04754nam 2200397z- 450 001 9910136400303321 005 20210212 035 $a(CKB)3710000000612088 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58038 035 $a(oapen)doab58038 035 $a(EXLCZ)993710000000612088 100 $a20202102d2014 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRegulation of immune system cell functions by protein kinase C 210 $cFrontiers Media SA$d2014 215 $a1 online resource (129 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-326-8 330 $aMembers of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. Most PKC proteins are ubiquitously expressed and participate in a plethora of functions in most cell types. A majority of PKC isoforms is also expressed in cells of the immune system in which they are involved in signal transduction downstream of a range of surface receptors, including the antigen receptors on T and B lymphocytes. PKC proteins are central to signal initiation and propagation, and to the regulation of processes leading to immune cell proliferation, differentiation, homing and survival. As a result, PKC proteins directly impact on the quality and quantity of immune responses and indirectly on the host resistance to pathogens and tendency to develop immune deficiencies and autoimmune diseases. A significant progress was made in recent years in understanding the regulation of PKC enzymes, their mechanism of action and their role in determining immunocyte behavior This volume reviews the most significant contributions made in the field of immune cell regulation by PKC enzymes. Several manuscripts are devoted to the role of distinct PKC isoforms in the regulation of selected immunocyte responses. Additional manuscripts review more general mechanisms of regulation of PKC enzymes, either by post-translational modifications, such as phosphorylation or controlled proteolysis, or by interaction with different binding proteins that may alter the conformation, activity and subcellular location of PKC. Both types of mechanisms can introduce conformational changes in the molecule, which may affect its ability to interact with cofactors, ATP, or substrates. This topic will be followed by a discussion on the positive and negative impact of individual PKC isoforms on cell cycle regulation. A second section of this volume concentrates on selected topics relevant to role of the novel PKC isoform, PKC-theta, in T lymphocyte function. PKC-theta plays important and some non-redundant roles in T cell activation and is a key isoform that recruits to the immunological synapse - the surface membrane area in T cells that comes in direct contact with antigen presenting cells. The immunological synapse is formed in T cells within seconds following the engagement of the TCR by a peptide-bound MHC molecule on the surface of antigen-presenting cells. It serves as a platform for receptors, adaptor proteins, and effector molecules, which assemble into multimolecular activation complexes required for signal transduction. The unique ability of PKC-theta to activate the NF-kB, AP-1 and NF-AT transcription factors is well established, and recent studies contributed essential information on the mechanisms involved in the recruitment of PKC-theta to the center of the immunological synapse and the nature of its substrates and the role of their phosphorylated forms in signal transduction. Additional review manuscripts will describe the unique behavior of PKC-theta in regulatory T cells and its role in the regulation of other cell populations, including those of the innate immune response. This volume brings together leading experts from different disciplines that review the most recent discoveries and offer new perspectives on the contributions of PKC isoforms to biochemical processes and signaling events in different immune cell populations and their impact on the overall host immune response. 606 $aMedicine$2bicssc 610 $acell growth regulation 610 $alymphocyte stimulation 610 $aProtein Kinase C 610 $asignal transduction pathways 610 $aT cell activation 615 7$aMedicine 700 $aAmnon Altman$4auth$01277564 702 $aNoah Isakov$4auth 906 $aBOOK 912 $a9910136400303321 996 $aRegulation of immune system cell functions by protein kinase C$93011642 997 $aUNINA