LEADER 03739oam 22007334a 450 001 9910452779603321 005 20211004152522.0 010 $a0-691-16847-4 010 $a1-4008-4846-6 024 7 $a10.1515/9781400848461 035 $a(CKB)2550000001125726 035 $a(EBL)1329785 035 $a(SSID)ssj0001001028 035 $a(PQKBManifestationID)12394589 035 $a(PQKBTitleCode)TC0001001028 035 $a(PQKBWorkID)10966637 035 $a(PQKB)11448522 035 $a(MiAaPQ)EBC1329785 035 $a(StDuBDS)EDZ0000142002 035 $a(DE-B1597)474190 035 $a(OCoLC)1004867046 035 $a(DE-B1597)9781400848461 035 $a(PPN)199244251 035 $a(OCoLC)1273306595 035 $a(MdBmJHUP)musev2_77334 035 $a(EXLCZ)992550000001125726 100 $a20150921e20162013 uy 0 101 0 $aeng 135 $aur|nu---|u||u 181 $ctxt 182 $cc 183 $acr 200 14$aThe Alzheimer Conundrum$eEntanglements of Dementia and Aging /$fMargaret Lock 205 $aCourse Book 210 1$aPrinceton :$cPrinceton University Press,$d2016. 210 4$dİ2016. 215 $a1 online resource (323 p.) 300 $aOriginally published: 2013. 311 0 $a0-691-14978-X 311 0 $a1-299-95116-3 320 $aIncludes bibliographical references and index. 327 $aAcknowledgments -- Orientations -- Making and remaking Alzheimer disease -- Striving to standardize Alzheimer disease -- Paths to Alzheimer prevention -- Embodied risk made visible -- Alzheimer genes: biomarkers of prediction and prevention -- Genome-wide association studies: back to the future -- Living with embodied omens -- Chance untamed and the return of fate -- Transcending entrenched tensions -- Portraits from the mind -- Notes -- Bibliography -- Index. 330 $aDue to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer's disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure. 606 $aOlder people$xMental health$2fast$3(OCoLC)fst01199117 606 $aBrain$xAging$xMolecular aspects$2fast$3(OCoLC)fst00837576 606 $aAlzheimer's disease$xAge factors$2fast$3(OCoLC)fst01750368 606 $aBrain$xAging$xMolecular aspects 606 $aOlder people$xMental health 606 $aAlzheimer's disease$xAge factors 608 $aElectronic books. 615 0$aOlder people$xMental health. 615 0$aBrain$xAging$xMolecular aspects. 615 0$aAlzheimer's disease$xAge factors. 615 0$aBrain$xAging$xMolecular aspects. 615 0$aOlder people$xMental health. 615 0$aAlzheimer's disease$xAge factors. 676 $a362.1968/31 700 $aLock$b Margaret M.$01009391 801 0$bMdBmJHUP 801 1$bMdBmJHUP 906 $aBOOK 912 $a9910452779603321 996 $aThe Alzheimer conundrum$92463738 997 $aUNINA