LEADER 05356nam 2200637 a 450 001 9910452500203321 005 20200520144314.0 010 $a0-12-405535-4 035 $a(CKB)2550000001108357 035 $a(EBL)1337491 035 $a(OCoLC)855505337 035 $a(SSID)ssj0001141597 035 $a(PQKBManifestationID)11695655 035 $a(PQKBTitleCode)TC0001141597 035 $a(PQKBWorkID)11090273 035 $a(PQKB)11141669 035 $a(MiAaPQ)EBC1337491 035 $a(PPN)17663889X 035 $a(Au-PeEL)EBL1337491 035 $a(CaPaEBR)ebr10744527 035 $a(CaONFJC)MIL508707 035 $a(EXLCZ)992550000001108357 100 $a20130822d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAutophagy$b[electronic resource] $hVolume 1$ecancer, other pathologies, inflammation, immunity, infection, and aging /$fedited by M. A. Hayat 210 $aSan Diego, Calif. $cAcademic Press$dc2014 215 $a1 online resource (360 p.) 300 $aDescription based upon print version of record. 311 $a0-12-405530-3 311 $a1-299-77456-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging; Copyright Page; Dedication; Contents; Preface; Contributors; List of Contributions Projected in Volumes 2-4; Abbreviations and Glossary; 1 Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1-4; Introduction; Specific Functions of Autophagy (A Summary); Autophagy in Normal Mammalian Cells; Major Types of Autophagies; Macroautophagy (Autophagy); Microautophagy; Chaperone-Mediated Autophagy; Selective Autophagies; Autophagosome Formation 327 $aAutophagic Lysosome ReformationAutophagic Proteins; Protein Degradation Systems; Beclin 1; Non-Autophagic Function of Autophagy-Related Proteins; Microtubule-Associated Protein Light Chain 3; Monitoring Autophagy; Reactive Oxygen Species (ROS); Mammalian Target of Rapamycin (mTOR); Role of Autophagy in Tumorigenesis and Cancer; Role of Autophagy in Immunity; Role of Autophagy in Viral Defense and Replication; Role of Autophagy in Intracellular Bacterial Infection; Role of Autophagy in Heart Disease; Role of Autophagy in Neurodegenerative Diseases; Cross-Talk between Autophagy and Apoptosis 327 $aReferencesI General Diseases; 2 Mechanisms of Regulation of p62 in Autophagy and Implications for Health and Diseases; Introduction; LC3 Recognition by p62; Interacting Region between LC3 and p62; Overall Structure of the LC3-p62-LRS Complex; Characterization of Atg8 Homologue-LRS Domain; Role of p62 as an Autophagy Receptor; Autophagic Degradation of p62; Requirement of the PB1 Domain for p62 Degradation; Ubiquitin- and p62-Positive Inclusion Formation; Discussion; References; 3 Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases; Autophagy Overview and Types 327 $aPathway and Mechanism for AutophagyInitiation; Nucleation; Elongation; Maturation/Fusion with Lysosomes; Physiological Roles of Autophagy; Autophagy and Neuronal Physiology; Quality Control; Development and Differentiation; Autophagy and Neurodegenerative Diseases; Alzheimer's Disease; Parkinson's Disease; Huntington's Disease; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Cerebral Ischemia (Injury); Conclusions and Future Perspective; Acknowledgments; References; 4 Roles of Multiple Types of Autophagy in Neurodegenerative Diseases 327 $aDegradation of ALS-Linked Mutant SOD1 by MacroautophagyInteraction between Parkinson's Disease-Associated UCH-L1 and Chaperone-Mediated Autophagy; Degradation of RNA by Rnautophagy: Its Possible Roles in Neurodegenerative Disorders; References; 5 Autophagy and Crohn's Disease: Towards New Therapeutic Connections; Introduction: Crohn's Disease and Faulty Autophagy go Hand in Hand; Autophagy: A Hot Novel Target or an Old Friend?; Autophagy Regulates Immunity; Anti-TNF-?; Thiopurines; Curcumin; Direct Autophagy Modulators; Diagnostic Value of the Autophagic Status; Concluding Remarks; References 327 $a6 The Role of Autophagy in Atherosclerosis 330 $a Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, ma 606 $aCellular immunity 606 $aCancer$xResearch 608 $aElectronic books. 615 0$aCellular immunity. 615 0$aCancer$xResearch. 676 $a616.079 701 $aHayat$b M. A$086169 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910452500203321 996 $aAutophagy$92038659 997 $aUNINA