LEADER 05722nam 2200721 a 450 001 9910452436203321 005 20200520144314.0 010 $a1-280-87969-6 010 $a9786613721006 010 $a90-272-7458-4 035 $a(CKB)2550000000109658 035 $a(EBL)949202 035 $a(OCoLC)797918089 035 $a(SSID)ssj0000690306 035 $a(PQKBManifestationID)12302891 035 $a(PQKBTitleCode)TC0000690306 035 $a(PQKBWorkID)10621786 035 $a(PQKB)10269784 035 $a(MiAaPQ)EBC949202 035 $a(Au-PeEL)EBL949202 035 $a(CaPaEBR)ebr10574851 035 $a(CaONFJC)MIL372100 035 $a(EXLCZ)992550000000109658 100 $a20120202d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aInflection and word formation in Romance languages$b[electronic resource] /$fedited by Sascha Gaglia, Marc-Olivier Hinzelin 210 $aAmsterdam ;$aPhiladelphia $cJohn Benjamins Pub. Co.$d2012 215 $a1 online resource (408 p.) 225 1 $aLinguistik aktuell/linguistics today ;$vv. 186 300 $aDescription based upon print version of record. 311 $a90-272-5569-5 320 $aIncludes bibliographical references and index. 327 $aInflection and Word Formation in Romance Languages; Editorial page; Title page; LCC data; Table of contents; Acknowledgements; Morphological theories, the Autonomy of Morphology, and Romance data; 1. Introduction; 2. The Autonomy of Morphology; 3. Autonomous patterns in Romance inflectional morphology; 3.1 Patterns of stem alternants in the Romance verb; 3.2 Syncretism as an autonomous morphological pattern; 3.3 Case study: The neutralization of Franco provenc?al person prefixes; 3.4 Inflectional classes; 4. Lexical Phonology and Morphology as a non-autonomous model 327 $a5. Formal theories of inflectional morphology 5.1 Paradigm Function Morphology (PFM); 6. Autonomous morphology and word formation; 7. Summary and structure of the present volume; Bibliography; A Paradox?; 1. Emergence of the distinctive present subjunctive root; 2. Two unexpected developments; 2.1 Type A; 2.2 Type B; 3. A 'morphomic reaction'?; 4. Type B as reinforcement of autonomous morphological structure; 5. Conclusion; References; Verb morphology gone astray; 1. Introduction; 2. Syncretism patterns; 2.1 Syncretism patterns in the Western Romance languages 327 $a2.2 Syncretism patterns in occitan varieties 2.3 Syncretism patterns in francoprovenc?al varieties; 2.4 Syncretism patterns in oi?l varieties; 2.5 Results of the gallo-romance comparison and perspectives on the nature of syncretism; 2.5.1 A typology of verb paradigms in Western Romance; 2.5.2 Assumption of a system-structuring function of syncretism; 3. Suppletion patterns; 3.1 Romance distribution patterns: a 'morphomic' structure; 3.2 Interaction of suppletion and syncretism: The verb 'to go'; 3.3 Interaction of suppletion and syncretism: The verb 'to be' 327 $a4. Summary and perspectives on language change at the interface References; The Friulian subject clitics; 1. Introduction; 2. Linguistic description; 2.1 Modern Friulian; 2.2 The use of subject pronouns in modern Friulian; 2.2.1 Realisation and non-realisation; 2.2.2 Quantitative results for (non-)realisation and methodology; 3. Analysis: Syntax, morphology, and phonology; 3.1 The syntax of scls: Synchrony and diachrony; 3.2 Syncretism and its avoidance in modern Friulian; 3.3 Non-Realisation as the result of two distinct processes; 3.4 The scl paradigms from a diachronic perspective 327 $a3.4.1 Feature-based extension 3.4.2 Morphomic analysis; 4. Summary; References; Appendix; Romance clitic pronouns in lexical paradigms; 2. The grammatical status of clitics; 3. Clitic paradigms; 3.1 Agreement features; 3.2 Features related to argument structure; 3.3 Linear arrangement features; 3.4 Paradigms for French and Italian; 3.5 Clitic clusters; 4. Mapping case features on grammatical functions; 4.1 The partitive; 4.2 Clitics with no grammatical function; 4.3 The mapping from Case to grammatical function in Italian; 4.4 Clitic paradigms in the architecture of grammar 327 $a5. Closing remarks and outlook 330 $aMorphology, and in particular word formation, has always played an important role in Romance linguistics since it was introduced in Diez's comparative Romance grammar. Recent years have witnessed a surge of interest in inflectional morphology, and current research shows a strong interest in paradigmatic analyses. This volume brings together research exploring different areas of morphology from a variety of theoretical and methodological perspectives. On an empirical basis, the theoretical assumption of the 'Autonomy of Morphology' is discussed critically. 'Data-driven' approaches carefully 410 0$aLinguistik aktuell ;$vBd. 186. 606 $aRomance languages$xWord formation 606 $aRomance languages$xInflection 606 $aRomance languages$xMorphology 606 $aRomance languages$xGrammar, Comparative 608 $aElectronic books. 615 0$aRomance languages$xWord formation. 615 0$aRomance languages$xInflection. 615 0$aRomance languages$xMorphology. 615 0$aRomance languages$xGrammar, Comparative. 676 $a440/.0459 701 $aGaglia$b Sascha$0897583 701 $aHinzelin$b Marc-Olivier$0897584 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910452436203321 996 $aInflection and word formation in Romance languages$92005401 997 $aUNINA LEADER 05406nam 2201381z- 450 001 9910585940503321 005 20220812 035 $a(CKB)5600000000483077 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91184 035 $a(oapen)doab91184 035 $a(EXLCZ)995600000000483077 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aFrom a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (234 p.) 311 08$a3-0365-4753-3 311 08$a3-0365-4754-1 330 $aThis book collects contributions published in the Special Issue "From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential" and dealing with successful stories of drug improvement or design using classic protocols, quantum mechanical mechanistic investigation, or hybrid approaches such as QM/MM or QM/ML (machine learning). In the last two decades, computer-aided modeling has strongly supported scientists' intuition to design functional molecules. High-throughput screening protocols, mainly based on classical mechanics' atomistic potentials, are largely employed in biology and medicinal chemistry studies with the aim of simulating drug-likeness and bioactivity in terms of efficient binding to the target receptors. The advantages of this approach are quick outcomes, the possibility of repurposing commercially available drugs, consolidated protocols, and the availability of large databases. On the other hand, these studies do not intrinsically provide reactivity information, which requires quantum mechanical methodologies that are only applicable to significantly smaller and simplified systems at present. These latter studies focus on the drug itself, considering the chemical properties related to its structural features and motifs. 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