LEADER 05188nam 2200649Ia 450 001 9910452307003321 005 20200520144314.0 010 $a1-299-46292-8 010 $a1-84816-837-3 035 $a(CKB)2550000001019212 035 $a(EBL)1168140 035 $a(SSID)ssj0000908051 035 $a(PQKBManifestationID)11943990 035 $a(PQKBTitleCode)TC0000908051 035 $a(PQKBWorkID)10898843 035 $a(PQKB)11193598 035 $a(MiAaPQ)EBC1168140 035 $a(WSP)00002961 035 $a(Au-PeEL)EBL1168140 035 $a(CaPaEBR)ebr10699131 035 $a(CaONFJC)MIL477542 035 $a(OCoLC)841913828 035 $a(EXLCZ)992550000001019212 100 $a20040914d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe neutrophils$b[electronic resource] $enew outlook for old cells /$feditor, Dmitry I. Gabrilovich 205 $a3rd ed. 210 $aLondon $cImperial College Press ;$aSingapore ;$aHackensack, NJ $cDistributed by World Scientific Pub.$dc2013 215 $a1 online resource (447 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-836-5 320 $aIncludes bibliographical references and index. 327 $aList of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF) 327 $a1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBP? - Generation of GMP from CMP; 1.3.2.3 C/EBP? - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox 327 $a2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; References 327 $aChapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References 327 $aChapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions 327 $a4.5.5 PECAM-1 330 $aThis is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of 606 $aNeutrophils 606 $aImmunology 608 $aElectronic books. 615 0$aNeutrophils. 615 0$aImmunology. 676 $a571.96 701 $aGabrilovich$b Dmitry I$0912645 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910452307003321 996 $aThe neutrophils$92043963 997 $aUNINA