LEADER 05254nam 2200649 a 450 001 9910452084203321 005 20200520144314.0 010 $a1-280-66902-0 010 $a9786613645951 010 $a1-84816-827-6 035 $a(CKB)2550000000101405 035 $a(EBL)919057 035 $a(OCoLC)794328358 035 $a(SSID)ssj0000657694 035 $a(PQKBManifestationID)12291824 035 $a(PQKBTitleCode)TC0000657694 035 $a(PQKBWorkID)10655960 035 $a(PQKB)11271585 035 $a(MiAaPQ)EBC919057 035 $a(WSP)0000P819 035 $a(Au-PeEL)EBL919057 035 $a(CaPaEBR)ebr10563496 035 $a(CaONFJC)MIL364595 035 $a(EXLCZ)992550000000101405 100 $a20120608d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNobel Prizes that changed medicine$b[electronic resource] /$feditor, Gilbert Thompson 210 $aLondon $cImperial College Press$d2012 215 $a1 online resource (373 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-825-X 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Foreword by Sir Keith Peters; Preface by Gilbert Thompson; Acknowledgements; Contributors; Chapter 1 The Discovery of Insulin Robert Tattersall; 1.1 Introduction; 1.2 The Pancreas and Diabetes; 1.3 Banting and Macleod 9; 1.4 The First Clinical Test; 1.5 The Nobel Prize; 1.6 The Long-term Impact of the Discovery; References; Chapter 2 The Discovery of the Cure for Pernicious Anaemia, Vitamin B12 A. Victor Hoffbrand; 2.1 Introduction; 2.2 Brief Biographies; 2.2.1 George Whipple; 2.2.2 George Minot; 2.2.3 William Murphy; 2.3 The Medical Problem; 2.4 Possible Mechanisms 327 $a2.4.1 The nutritional deficiency concept 2.4.2 Why liver therapy worked; 2.5 Subsequent Research; 2.5.1 Isolation of vitamin B12; 2.5.2 Extrinsic and intrinsic factors; 2.5.3 Discovery of folic acid; 2.5.4 Two vitamins; 2.5.5 Vitamin B12/folate interactions; 2.5.6 Neurological damage; 2.5.7 Systemic effects of vitamin and folate deficiencies; 2.6 Impact of the Discovery of Vitamin B12 on Medical Practice; References; Chapter 3 The Discovery of Penicillin Eric Sidebottom; 3.1 Introduction; 3.2 Biographical Sketches 10; 3.2.1 Alexander Fleming; 3.2.1.1 Education and career 327 $a3.2.1.2 The antibiotic revolution and the Fleming myth 3.2.1.3 The man and his achievements; 3.2.2 Howard Florey; 3.2.2.1 Move to England; 3.2.2.2 Cambridge and early work on lysozyme; 3.2.2.3 Chair of Pathology in Oxford and the development of penicillin; 3.2.2.4 Recognition and its rewards; 3.2.3 Ernst Chain; 3.2.3.1 Move to Britain; 3.2.3.2 Moves to and from Rome; 3.3 Steps in the Discovery and Development of Penicillin; 3.4 The Impact of the Introduction of Penicillin into Clinical Practice; 3.5 From Triumph to Tragedy?; 3.6 The Creation of the Fleming Myth 327 $a3.7 Allocation of Credit Due and Conclusions References; Chapter 4 The Introduction of Cardiac Catheterisation Tony Seed; 4.1 Prologue; 4.2 Introduction; 4.3 Biographical Background of the Laureates; 4.3.1 Werner Forssmann; 4.3.2 Andre? Cournand; 4.3.3 Dickinson Richards; 4.4 The Problem: Cardiopulmonary Physiology and Clinical Investigation of the Heart 80 Years Ago; 4.5 Description of the Research; 4.6 Impact of Cardiac Catheterisation on Medical Science; Acknowledgements; References; Chapter 5 The Discovery of the Structure of DNA James Scott and Gilbert Thompson; 5.1 Introduction 327 $a5.2 Brief Biographies of the Major Protagonists 5.2.1 Francis Crick; 5.2.2 James Watson; 5.2.3 Maurice Wilkins; 5.2.4 Rosalind Franklin; 5.3 Early Discoveries that Paved the Way to Unraveling the Structure of DNA; 5.4 Complementary Approaches to Analysing the Structure of DNA in the 1950's; 5.4.1 Model building at the Cavendish and X-ray diffraction at King's; 5.4.2 The wrong model; 5.4.3 The correct model; 5.5 Impact of the Discovery of the Structure of DNA on Medical Science; 5.5.1 Mendelian genetics; 5.5.2 The HapMap Project; 5.5.3 Human history 327 $a5.5.4 The genomic basis of common diseases and traits 330 $aThis book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more person 606 $aNobel Prizes 606 $aMedicine 608 $aElectronic books. 615 0$aNobel Prizes. 615 0$aMedicine. 676 $a610.79 701 $aThompson$b Gilbert$0940973 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910452084203321 996 $aNobel Prizes that changed medicine$92122031 997 $aUNINA LEADER 05176nam 2200769 450 001 9910453658203321 005 20200903223051.0 010 $a90-04-26014-5 035 $a(CKB)2550000001168872 035 $a(EBL)1576648 035 $a(SSID)ssj0001060700 035 $a(PQKBManifestationID)11985603 035 $a(PQKBTitleCode)TC0001060700 035 $a(PQKBWorkID)11105905 035 $a(PQKB)10762572 035 $a(MiAaPQ)EBC1576648 035 $a(nllekb)BRILL9789004260146 035 $a(Au-PeEL)EBL1576648 035 $a(CaPaEBR)ebr10815243 035 $a(CaONFJC)MIL550158 035 $a(OCoLC)865156534 035 $a(PPN)178885266 035 $a(EXLCZ)992550000001168872 100 $a20130830d2014 uy| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe challenge of linear time $enationhood and the politics of history in East Asia /$fedited by Viren Murthy and Axel Schneider 210 1$aLeiden :$cBrill,$d2014. 215 $a1 online resource (311 p.) 225 1 $aLeiden series in comparative historiography,$x1574-4493 ;$vvolume 7 300 $aDescription based upon print version of record. 311 $a90-04-26013-7 311 $a1-306-18907-1 320 $aIncludes bibliographical references and index. 327 $aIntroduction / Viren Murthy, Axel Schneider -- [1] Time, history, and moral responsibility -- Negativity and historicist time : facticity and intellectual history of the 1930s / Naoki Sakai -- Ontological optimism, cosmological confusion, and unstable evolution : Tan Sitong's Renxue and Zhang Taiyan's response / Viren Murthy -- Nation, history and ethics : the choices of post-imperial historiography in China / Axel Schneider -- Reading Takeuchi Yoshimi and reading history / Sun Ge -- [2] The burden of the past and the hope for a better future -- An eschatological view of history : Yoshimi Takeuchi in the 1960s / Takahiro Nakajima -- The campaign to criticize Lin Biao and Confucius and the problem of "Restoration" in Chinese Marxist historiography / Susanne Weigelin-Schwiedrzik -- [3] Recollection of the past and the popularization of history -- Popular readings and wartime historical writings in modern China / Long-Hsin Liu -- Figuring history and horror in a provincial museum : the water dungeon, the rent collection courtyard, and the socialist undead / Haiyan Lee -- [4] History and the definition of spatial, cultural and temporal boundaries -- Revolution as restoration : meanings of "national essence" and "national learning" in Guocui Xuebao / Tze-Ki Hon -- Temporality of knowledge and history writing in early twentieth-century China : Liu Yizheng and The history of Chinese culture / Ya-Pei Kuo. 330 $aThe papers collected in this volume congeal around a debate about the ways and extent of the dominance of linear time and progressive history and the concomitant delineation of the nation in Chinese and Japanese historiography. As China and Japan entered the global capitalist system of nation states, the Chinese and Japanese regimes implemented a number of reforms, which resulted in transformations that affected everyday experience. In the face of imperialism and the perceived threat of being split up, the Meiji and late Qing governments radically reoriented policies in order to become wealthy and powerful in the global arena. People not only began to experience time and space in new ways, but elites also were increasingly exposed to Western theories of history and concepts of nationhood, which became dominant. These changes contributed to the production of new types of historical consciousness and collective identity. The essays in this volume each provide a perspective on the complex ways in which imagining national and regional identity in East Asia were and continue to be enmeshed with visions of time and history. This book should be of interest to all those who are interested in nationalism, modernity in China and Japan, global capitalism and the politics of time. 410 0$aLeiden series in comparative historiography ;$vv. 7. 606 $aHistoriography$xPolitical aspects$zChina 606 $aHistoriography$xPolitical aspects$zJapan 606 $aTime$xPolitical aspects$zChina 606 $aTime$xPolitical aspects$zJapan 606 $aNationalism$zChina 606 $aNationalism$zJapan 607 $aChina$xHistoriography 607 $aJapan$xHistoriography 607 $aChina$xIntellectual life$y20th century 607 $aJapan$xIntellectual life$y20th century 608 $aElectronic books. 615 0$aHistoriography$xPolitical aspects 615 0$aHistoriography$xPolitical aspects 615 0$aTime$xPolitical aspects 615 0$aTime$xPolitical aspects 615 0$aNationalism 615 0$aNationalism 676 $a951.0072 701 $aMurthy$b Viren$0897337 701 $aSchneider$b Axel$0970924 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910453658203321 996 $aThe challenge of linear time$92206842 997 $aUNINA