LEADER 05254nam 2200649 a 450 001 9910452084203321 005 20200520144314.0 010 $a1-280-66902-0 010 $a9786613645951 010 $a1-84816-827-6 035 $a(CKB)2550000000101405 035 $a(EBL)919057 035 $a(OCoLC)794328358 035 $a(SSID)ssj0000657694 035 $a(PQKBManifestationID)12291824 035 $a(PQKBTitleCode)TC0000657694 035 $a(PQKBWorkID)10655960 035 $a(PQKB)11271585 035 $a(MiAaPQ)EBC919057 035 $a(WSP)0000P819 035 $a(Au-PeEL)EBL919057 035 $a(CaPaEBR)ebr10563496 035 $a(CaONFJC)MIL364595 035 $a(EXLCZ)992550000000101405 100 $a20120608d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNobel Prizes that changed medicine$b[electronic resource] /$feditor, Gilbert Thompson 210 $aLondon $cImperial College Press$d2012 215 $a1 online resource (373 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-825-X 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Foreword by Sir Keith Peters; Preface by Gilbert Thompson; Acknowledgements; Contributors; Chapter 1 The Discovery of Insulin Robert Tattersall; 1.1 Introduction; 1.2 The Pancreas and Diabetes; 1.3 Banting and Macleod 9; 1.4 The First Clinical Test; 1.5 The Nobel Prize; 1.6 The Long-term Impact of the Discovery; References; Chapter 2 The Discovery of the Cure for Pernicious Anaemia, Vitamin B12 A. Victor Hoffbrand; 2.1 Introduction; 2.2 Brief Biographies; 2.2.1 George Whipple; 2.2.2 George Minot; 2.2.3 William Murphy; 2.3 The Medical Problem; 2.4 Possible Mechanisms 327 $a2.4.1 The nutritional deficiency concept 2.4.2 Why liver therapy worked; 2.5 Subsequent Research; 2.5.1 Isolation of vitamin B12; 2.5.2 Extrinsic and intrinsic factors; 2.5.3 Discovery of folic acid; 2.5.4 Two vitamins; 2.5.5 Vitamin B12/folate interactions; 2.5.6 Neurological damage; 2.5.7 Systemic effects of vitamin and folate deficiencies; 2.6 Impact of the Discovery of Vitamin B12 on Medical Practice; References; Chapter 3 The Discovery of Penicillin Eric Sidebottom; 3.1 Introduction; 3.2 Biographical Sketches 10; 3.2.1 Alexander Fleming; 3.2.1.1 Education and career 327 $a3.2.1.2 The antibiotic revolution and the Fleming myth 3.2.1.3 The man and his achievements; 3.2.2 Howard Florey; 3.2.2.1 Move to England; 3.2.2.2 Cambridge and early work on lysozyme; 3.2.2.3 Chair of Pathology in Oxford and the development of penicillin; 3.2.2.4 Recognition and its rewards; 3.2.3 Ernst Chain; 3.2.3.1 Move to Britain; 3.2.3.2 Moves to and from Rome; 3.3 Steps in the Discovery and Development of Penicillin; 3.4 The Impact of the Introduction of Penicillin into Clinical Practice; 3.5 From Triumph to Tragedy?; 3.6 The Creation of the Fleming Myth 327 $a3.7 Allocation of Credit Due and Conclusions References; Chapter 4 The Introduction of Cardiac Catheterisation Tony Seed; 4.1 Prologue; 4.2 Introduction; 4.3 Biographical Background of the Laureates; 4.3.1 Werner Forssmann; 4.3.2 Andre? Cournand; 4.3.3 Dickinson Richards; 4.4 The Problem: Cardiopulmonary Physiology and Clinical Investigation of the Heart 80 Years Ago; 4.5 Description of the Research; 4.6 Impact of Cardiac Catheterisation on Medical Science; Acknowledgements; References; Chapter 5 The Discovery of the Structure of DNA James Scott and Gilbert Thompson; 5.1 Introduction 327 $a5.2 Brief Biographies of the Major Protagonists 5.2.1 Francis Crick; 5.2.2 James Watson; 5.2.3 Maurice Wilkins; 5.2.4 Rosalind Franklin; 5.3 Early Discoveries that Paved the Way to Unraveling the Structure of DNA; 5.4 Complementary Approaches to Analysing the Structure of DNA in the 1950's; 5.4.1 Model building at the Cavendish and X-ray diffraction at King's; 5.4.2 The wrong model; 5.4.3 The correct model; 5.5 Impact of the Discovery of the Structure of DNA on Medical Science; 5.5.1 Mendelian genetics; 5.5.2 The HapMap Project; 5.5.3 Human history 327 $a5.5.4 The genomic basis of common diseases and traits 330 $aThis book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more person 606 $aNobel Prizes 606 $aMedicine 608 $aElectronic books. 615 0$aNobel Prizes. 615 0$aMedicine. 676 $a610.79 701 $aThompson$b Gilbert$0940973 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910452084203321 996 $aNobel Prizes that changed medicine$92122031 997 $aUNINA